Výsledky vyhledávání - "Jonathan Metts"

Akademický článek

Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy

Autor: Darcy L. Welch, Brooke L. Fridley, Ling Cen, Jamie K. Teer, Sean J. Yoder, Fredrik Pettersson, Liping Xu, Chia-Ho Cheng, Yonghong Zhang, Mark G. Alexandrow, Shengyan Xiang, Mark Robertson-Tessi, Joel S. Brown, Jonathan Metts, Andrew S. Brohl, Damon R. Reed

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a s

Externí odkaz: https://doaj.org/article/f7513fb0926f4a94b84dd06a5b81bbee

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Akademický článek

Oncolytic Viral Therapy in Osteosarcoma

Autor: Thomas Karadimas, Thien Huong Huynh, Chloe Chose, Guston Zervoudakis, Bryan Clampitt, Sean Lapp, David Joyce, George Douglas Letson, Jonathan Metts, Odion Binitie, John E. Mullinax, Alexander Lazarides

Publikováno v: Viruses, Vol 16, Iss 7, p 1139 (2024)

Primary bone malignancies, including osteosarcoma (OS), are rare but aggressive. Current OS treatment, involving surgical resection and chemotherapy, has improved survival for non-metastatic cases but remains ineffective for recurrent or metastatic O

Externí odkaz: https://doaj.org/article/c308cbcdccbf4a6b9246d6e9332da5fa

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Akademický článek

Gastrointestinal Complications of Intra-Abdominal Desmoid Tumors: A Case Report and Review of the Literature

Autor: Darcy Morris, Raquel Gonzalez, Jane Cook, Jonathan Metts, Peter Shaw

Publikováno v: Case Reports in Oncology, Vol 15, Iss 2, Pp 515-521 (2022)

A 15-year-old male with a mesenteric desmoid tumor and underlying familial adenomatous polyposis presented 2 weeks after initiating sorafenib with severe abdominal pain and chills and was found to have an acute abdomen. Exploratory laparotomy reveale

Externí odkaz: https://doaj.org/article/0c4261b73d8b4129a07904c8057941a4

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Akademický článek

Primary Immunodeficiency in Children With Autoimmune Cytopenias: Retrospective 154-Patient Cohort

Autor: Emma Westermann-Clark, Cristina Adelia Meehan, Anna K. Meyer, Joseph F. Dasso, Devendra Amre, Maryssa Ellison, Bhumika Patel, Marisol Betensky, Charles Isaac Hauk, Jennifer Mayer, Jonathan Metts, Jennifer W. Leiding, Panida Sriaroon, Ambuj Kumar, Irmel Ayala, Jolan E. Walter

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundPrimary immunodeficiency is common among patients with autoimmune cytopenia.ObjectiveThe purpose of this study is to retrospectively identify key clinical features and biomarkers of primary immunodeficiency (PID) in pediatric patients with

Externí odkaz: https://doaj.org/article/4d1e3fa278d5481e970bc605a7c10d21

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Akademický článek

Case Report: A Novel Pathogenic Missense Mutation in FAS: A Multi-Generational Case Series of Autoimmune Lymphoproliferative Syndrome

Autor: Claudia L. Gaefke, Jonathan Metts, Donya Imanirad, Daime Nieves, Paola Terranova, Gianluca Dell'Orso, Eleonora Gambineri, Maurizio Miano, Richard F. Lockey, Jolan Eszter Walter, Emma Westermann-Clark

Publikováno v: Frontiers in Pediatrics, Vol 9 (2021)

Autoimmune Lymphoproliferative Syndrome (ALPS), commonly caused by mutations in the FAS gene, is a disease with variable penetrance. Subjects may be asymptomatic, or they may present with lymphadenopathy, splenomegaly, cytopenias, or malignancy. Prom

Externí odkaz: https://doaj.org/article/a617b76b801343cc8e461c03f73b75c5

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Akademický článek

Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia

Autor: Zhengqi Wang, Tian Mi, Heath L. Bradley, Jonathan Metts, Himalee Sabnis, Wandi Zhu, Jack Arbiser, Kevin D. Bunting

Publikováno v: Antioxidants, Vol 10, Iss 6, p 956 (2021)

Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathway

Externí odkaz: https://doaj.org/article/55cef3b857214f6c9597debf32e669f4

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Akademický článek

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells

Autor: Jonathan Metts, Heath L. Bradley, Zhengqi Wang, Neil P. Shah, Reuben Kapur, Jack L. Arbiser, Kevin D. Bunting

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, howev

Externí odkaz: https://doaj.org/article/194b5d0b84eb4fd8aa2867b88dfc9dc5

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