Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jonathan Merino"'
Autor:
Sneha Basak, Yong Li, Suyuan Tao, Fereidoon Daryaee, Jonathan Merino, Chendi Gu, Silvia L. Delker, Jenny N. Phan, Thomas E. Edwards, Stephen G. Walker, Peter J. Tonge
Publikováno v:
Journal of medicinal chemistry. 65(17)
UDP-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825f59f8c7569886ecc3e09d28036cee
https://pubmed.ncbi.nlm.nih.gov/36037447
https://pubmed.ncbi.nlm.nih.gov/36037447
Autor:
Hui Wang, James N. Iuliano, Sanjay K. Jain, Alvaro A. Ordonez, Fereidoon Daryaee, Yong Li, Grace E. Yoon, Kayla R. Gogarty, Jonathan Merino, Peter Smith-Jones, Edward A. Weinstein, Zhuo Zhang, Alvin S. Kalinda, Peter J. Tonge, Ronnie C. Mease
Publikováno v:
ACS Infectious Diseases. 4:1635-1644
Staphylococcus aureus is the leading cause of life-threatening infections, frequently originating from unknown or deep-seated foci. Source control and institution of appropriate antibiotics remain challenges, especially with infections due to methici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5283430cabb7ff515268a45537df39e
https://doi.org/10.1021/acsinfecdis.8b00182
https://doi.org/10.1021/acsinfecdis.8b00182
Autor:
Sandra Eltschkner, Weixuan Yu, Jonathan Merino, Caroline Kisker, James J. Truglio, Eleanor K. H. Allen, Ben Moree, Neil Thivalapill, Shabnam Davoodi, Lauren A. Spagnuolo, Peter J. Tonge, Joshua Salafsky, Richard A. Slayden, Fereidoon Daryaee, Annica Pschibul, Susan E. Knudson
Publikováno v:
Journal of the American Chemical Society. 139:3417-3429
A critical goal of lead compound selection and optimization is to maximize target engagement whilst minimizing off-target binding. Since target engagement is a function of both the thermodynamics and kinetics of drug-target interactions, it follows t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caeb1c371c30e265b18e7730ec471249
https://doi.org/10.1021/jacs.6b11148
https://doi.org/10.1021/jacs.6b11148
Autor:
Kayla R. Gogarty, Stewart L. Fisher, Jonathan Merino, Yong Li, Fereidoon Daryaee, Zhuo Zhang, Peter J. Tonge
Publikováno v:
Chemical Science. 8:3434-3443
Correlating target engagement with in vivo drug activity remains a central challenge in efforts to improve the efficiency of drug discovery. Previously we described a mechanistic pharmacokinetic–pharmacodynamic (PK/PD) model that used drug–target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1684ff881fe21a852d411af2ce3bda06
https://doi.org/10.1039/c6sc03306g
https://doi.org/10.1039/c6sc03306g
Autor:
Yong Li, Sneha Basak, Jonathan Merino, James N. Iuliano, Yuanyuan Si, Stephen G. Walker, Peter J. Tonge
Publikováno v:
ACS Infect Dis
Benzoxaboroles are a class of boron-containing compounds with a broad range of biological activities. A subset of benzoxaboroles have antimicrobial activity due primarily to their ability to inhibit leucyl-tRNA synthetase (LeuRS) via the oxaborole tR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79653e864b44915482282d43694b0798
https://europepmc.org/articles/PMC6625891/
https://europepmc.org/articles/PMC6625891/
Autor:
Zhuo, Zhang, Alvaro A, Ordonez, Hui, Wang, Yong, Li, Kayla R, Gogarty, Edward A, Weinstein, Fereidoon, Daryaee, Jonathan, Merino, Grace E, Yoon, Alvin S, Kalinda, Ronnie C, Mease, James N, Iuliano, Peter M, Smith-Jones, Sanjay K, Jain, Peter J, Tonge
Publikováno v:
ACS Infectious Diseases
Staphylococcus aureus is the leading cause of life-threatening infections, frequently originating from unknown or deep-seated foci. Source control and institution of appropriate antibiotics remain challenges, especially with infections due to methici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::183d55830accdc62591938750fba774d
https://pubmed.ncbi.nlm.nih.gov/30067329
https://pubmed.ncbi.nlm.nih.gov/30067329