Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Jonathan M. Percy"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 2660-2668 (2013)
Esters of crotonic acid were brominated on a multigramme scale using a free radical procedure. A phase transfer catalysed fluorination transformed these species to the 4-fluorobut-2E-enoates reproducibly and at scale (48–53%, ca. 300 mmol). Asymmet
Externí odkaz:
https://doaj.org/article/6b504ee1cfce4211bfa0d35ca47366e4
Publikováno v:
Chemistry – A European Journal. 25:5574-5585
The reaction of enol esters with SelectFluor is facile and leads to the corresponding α-fluoroketones under mild conditions and, as a result, this route is commonly employed for the synthesis of medicinally important compounds such as fluorinated st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20d50087d2f807484f79bed29f68768
https://doi.org/10.1002/chem.201900029
https://doi.org/10.1002/chem.201900029
Publikováno v:
Advanced Synthesis & Catalysis. 359:1007-1017
Traditional methods for the preparation of secondary alkyl-substituted aryl and heteroaryl chlorides challenge both selectivity and functional group tolerance. This contribution describes the use of statistical design of experiments to develop an eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a0784603924dcfb49dc7945a043c08
https://doi.org/10.1002/adsc.201601097
https://doi.org/10.1002/adsc.201601097
Publikováno v:
Chemical Science. 7:6369-6380
Electronic structure calculations have been used for the effective triage of substituent effects on difluorinated vinylcyclopropane precursors and their ability to undergo vinyl cyclopropane rearrangements (VCPR). Groups which effectively stabilised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb8f9d0e70e891378e971438ba5f68e
https://doi.org/10.1039/c6sc01289b
https://doi.org/10.1039/c6sc01289b
Autor:
Alan R. Kennedy, David Jonathan Hirst, Craig Jamieson, Magdalena Sommer, Jonathan M. Percy, Adam W. McCarter
The intramolecular carbocyclization of difluorinated enol acetals has been achieved for the first time using gold(I) catalysis. Difluorinated enol acetals bearing a pendant alkene group can be cyclized and reduced in one pot to form fluorinated diol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb15ff345812ade8870cf50cb255b4d
https://strathprints.strath.ac.uk/64934/1/McCarter_etal_JOC_2018_Atom_efficient_synthesis_of_selectively_difluorinated_carbocycles.pdf
https://strathprints.strath.ac.uk/64934/1/McCarter_etal_JOC_2018_Atom_efficient_synthesis_of_selectively_difluorinated_carbocycles.pdf
Autor:
Rebecca H. Graves, Panayiotis A. Procopiou, Simon Teanby Hodgson, Afjal Hussain Miah, Jonathan M. Percy, Aurelie C. Champigny
Publikováno v:
Bioorganicmedicinal chemistry. 25(20)
A novel 4-aminoindazole sulfonamide hit (13) was identified as a human CCR4 antagonists from testing a focussed library of compounds in the primary GTPγS assay. Replacing the indazole core with a pyrazolopyrimidine, and introduction of a methoxy gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3143f291710aea03db432202ed36e178
https://pubmed.ncbi.nlm.nih.gov/28801066
https://pubmed.ncbi.nlm.nih.gov/28801066
Autor:
Alison J. Ford, Panayiotis A. Procopiou, Jonathan M. Percy, Daniel E. O’Flynn, Malcolm Begg, Afjal Hussain Miah, Sally-Anne Rumley, Steve A. Richards, Benjamin J. Marsh, Hossay Abas
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4298-4311
A knowledge-based library of 2,3-dichlorophenylsulfonyl derivatives of commercially available aryl amines was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme. Hits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ada87b0d087a4a94ee27610b6391b0f
https://doi.org/10.1016/j.bmc.2014.05.021
https://doi.org/10.1016/j.bmc.2014.05.021
Autor:
Tell Tuttle, Bhaskar Mondal, Richard J. G. Black, Robin Wilkes, Jonathan M. Percy, Christopher North
Publikováno v:
Dalton Trans.. 43:469-478
Dispersion corrected density functional theory (DFT-D) has been applied to understand the performance of several palladium metal scavengers. Nine different sulfur-based ligands and three different palladium metal sets have been investigated in detail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12482cafe74b461d280f565ca0c36dd9
https://doi.org/10.1039/c3dt52282b
https://doi.org/10.1039/c3dt52282b
Publikováno v:
Dalton Trans.. 43:8493-8498
A DFT investigation into the mechanism for the decomposition of Grubbs 2nd generation pre-catalyst (2) in the presence of methanol, is presented. Gibbs free energy profiles for decomposition of the pre-catalyst (2) via two possible mechanisms were co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8080d2ef369f7bd4bef0c9cf026e39
https://doi.org/10.1039/c4dt00464g
https://doi.org/10.1039/c4dt00464g
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 2660-2668 (2013)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
Esters of crotonic acid were brominated on a multigramme scale using a free radical procedure. A phase transfer catalysed fluorination transformed these species to the 4-fluorobut-2E-enoates reproducibly and at scale (48–53%, ca. 300 mmol). Asymmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2f5c6587874f9812b665dd1e710386
https://doi.org/10.3762/bjoc.9.301
https://doi.org/10.3762/bjoc.9.301