Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jonathan M. O. Rawson"'
Autor:
Jonathan M. O. Rawson, Olga A. Nikolaitchik, Jennifer A. Yoo, Xayathed Somoulay, Matthew A. Brown, Franck S. Mbuntcha Bogni, Vinay K. Pathak, Ferri Soheilian, Ryan L. Slack, Stefan G. Sarafianos, Wei-Shau Hu
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Frequent recombination is a hallmark of retrovirus replication. In rare cases, recombination occurs between distantly related retroviruses, generating novel viruses that may significantly impact viral evolution and public health. These recom
Externí odkaz:
https://doaj.org/article/86bec7df75394f38ab143fb2a046a35d
Autor:
Jonathan M. O. Rawson, Olga A. Nikolaitchik, Saurabh Shakya, Brandon F. Keele, Vinay K. Pathak, Wei-Shau Hu
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL mol
Externí odkaz:
https://doaj.org/article/89982394a24744e38fdba9f5d128d102
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1538 (2023)
Viral diseases represent a major public health concerns and ever-present risks for developing into future pandemics. Antiviral antibody therapeutics, either alone or in combination with other therapies, emerged as valuable preventative and treatment
Externí odkaz:
https://doaj.org/article/ac65fe98a31d4dfb937e9e7ec43bf689
Publikováno v:
Viruses, Vol 13, Iss 2, p 173 (2021)
The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases. However, drug developmen
Externí odkaz:
https://doaj.org/article/2f70288ea3a24cf3a3bf3492e379fd36
Autor:
Ryan C. Burdick, Vinay K. Pathak, Wei-Shau Hu, MohamedHusen Munshi, Jonathan M. O. Rawson, Chenglei Li, Kunio Nagashima
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance For several decades, retroviral core uncoating has been thought to occur in the cytoplasm in coordination with reverse transcription, and while some recent studies have concluded that HIV-1 uncoating occurs at the nuclear envelope during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ce1f643596cb110f3c63162df7f69f
http://europepmc.org/articles/PMC7071919
http://europepmc.org/articles/PMC7071919
Autor:
Olga A. Nikolaitchik, Shuohui Liu, Jonathan P. Kitzrow, Yang Liu, Jonathan M. O. Rawson, Saurabh Shakya, Zetao Cheng, Vinay K. Pathak, Wei-Shau Hu, Karin Musier-Forsyth
Publikováno v:
Proc Natl Acad Sci U S A
To generate infectious virus, HIV-1 must package two copies of its full-length RNA into particles. HIV-1 transcription initiates from multiple, neighboring sites, generating RNA species that only differ by a few nucleotides at the 5' end, including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ab836905f395472b2283496b88eb03
https://doi.org/10.1073/pnas.2114494118
https://doi.org/10.1073/pnas.2114494118
Publikováno v:
Viruses
The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases. However, drug developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::377e7fbcba46b29518909e300c22c176
https://pubmed.ncbi.nlm.nih.gov/33498923
https://pubmed.ncbi.nlm.nih.gov/33498923
Autor:
Vinay K. Pathak, Jennifer A. Yoo, Wei-Shau Hu, Xayathed Somoulay, Olga A. Nikolaitchik, Jonathan M. O. Rawson
Publikováno v:
J Virol
The viral protein Gag selects full-length HIV-1 RNA from a large pool of mRNAs as virion genome during virus assembly. Currently, the precise mechanism that mediates the genome selection is not understood. Previous studies have identified several sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf849dd222bba9195e6d37a4080a2c7
https://pubmed.ncbi.nlm.nih.gov/32796062
https://pubmed.ncbi.nlm.nih.gov/32796062
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1354
The high mutation rate of human immunodeficiency virus type-1 (HIV-1) has been a pivotal factor in its evolutionary success as a human pathogen, driving the emergence of drug resistance, immune system escape, and invasion of distinct anatomical compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85f8a422fdcf959cf4c7e2155762f40f
https://pubmed.ncbi.nlm.nih.gov/26714706
https://pubmed.ncbi.nlm.nih.gov/26714706