Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jonathan M. Levenson"'
Autor:
Kelley C. Larson, Lauren H. Martens, Michael Marconi, Christopher Dejesus, Suzanne Bruhn, Thomas A. Miller, Barbara Tate, Jonathan M. Levenson
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Neuroinflammation is a key driver of neurodegenerative disease, however the tools available to model this disease biology at the systems level are lacking. We describe a translational drug discovery platform based on organotypic culture of m
Externí odkaz:
https://doaj.org/article/f99fd718d187495393c0c52cd3dd9f64
Autor:
Jonathan M. Levenson, Michael Grundman, Richard Fisher, Paul S. Aisen, K. Magnuson, Franz Hefti, D. Michelson, K. Marek, Martha L. Gray
Publikováno v:
The Journal of Prevention of Alzheimer's Disease. :1-4
The engineered fusion protein NPT088 targets amyloid in vitro and in animal models of Alzheimer’s disease. Previous studies showed that NPT088 treatment reduced β-amyloid plaque and tau aggregate loads in mouse disease models. Here, we present the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d5a1bdf6bb2c6f14900c5f381155f4
https://doi.org/10.14283/jpad.2019.37
https://doi.org/10.14283/jpad.2019.37
Autor:
Chris M Hempel, Michael Sivula, Jonathan M Levenson, David M Rose, Bing Li, Ana C Sirianni, Eva Xia, Timothy A Ryan, David J Gerber, Jeffrey R Cottrell
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25999 (2011)
Unbiased, high-throughput screening has proven invaluable for dissecting complex biological processes. Application of this general approach to synaptic function would have a major impact on neuroscience research and drug discovery. However, existing
Externí odkaz:
https://doaj.org/article/fdf71dfa2015421391b3c8b8a3106f35
Publikováno v:
PLoS ONE, Vol 1, p e138 (2006)
The formation of enduring internal representation of sensory information demands, in many cases, convergence in time and space of two different stimuli. The first conveys the sensory input, mediated via fast neurotransmission. The second conveys the
Externí odkaz:
https://doaj.org/article/7ddcc87e95bb4cc9885c1976ab1cbd4d
Autor:
Michal Lulu, Jonathan S. Wall, Richard V. Fisher, Ming Proschitsky, Stephen J. Kennel, Charlotte Chung, Jennifer E. Ward, Jonathan M. Levenson, Rajaraman Krishnan, Veruna Shibad
Publikováno v:
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 26(sup1)
We have previously described the discovery and development of GAIM (general amyloid interaction motif)-Ig (immunoglobulin) fusions as therapeutic candidates for neurodegenerative indications [1,2]....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b9b5b6e8725b9f5444a6494b248d74
https://pubmed.ncbi.nlm.nih.gov/31343324
https://pubmed.ncbi.nlm.nih.gov/31343324
Autor:
Edward Holgate, Michal Lulu, Jason Wright, Jonathan M. Levenson, Cassandra Rockwell-Postel, Richard Fisher, Eva Asp, Kim McDowell, Charlotte Chung, Rajaraman Krishnan, Ming Proschitsky, Haim Tsubery
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d84e65e6902a2363792963c3ceaef2a
https://doi.org/10.1016/j.jalz.2017.06.1400
https://doi.org/10.1016/j.jalz.2017.06.1400
Autor:
Christian J, Miedel, Jennifer M, Patton, Andrew N, Miedel, Edward S, Miedel, Jonathan M, Levenson
Publikováno v:
Journal of Visualized Experiments : JoVE
Here we describe a staged, behavioral testing approach that can be used to screen for compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in transgenic mouse models of β-amyloidosis and tauopathy. The paradigm include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8868768bd44ea62de18b995b19be9ed8
https://pubmed.ncbi.nlm.nih.gov/28605382
https://pubmed.ncbi.nlm.nih.gov/28605382
Autor:
Jennifer M. Patton, Christian J. Miedel, Andrew N. Miedel, Edward S. Miedel, Jonathan M. Levenson
Publikováno v:
Journal of Visualized Experiments.
Here we describe a staged, behavioral testing approach that can be used to screen for compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in transgenic mouse models of β-amyloidosis and tauopathy. The paradigm include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2ddd5c1606ceb5114b6694372b2d21
https://doi.org/10.3791/55523
https://doi.org/10.3791/55523
Autor:
Jeffrey R. Cottrell, Pascal Laeng, Jianping Song, Kelley C. Larson, Jonathan M. Levenson, Crystle J. Ashford, Betty Chan, David J. Gerber, Bing Li
Publikováno v:
SLAS Discovery. 19:205-214
Alterations in synaptic transmission have been implicated in a number of psychiatric and neurological disorders. The discovery of small-molecule modulators of proteins that regulate neurotransmission represents a novel therapeutic strategy for these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8cc2c390b4ba40b9291da5b40e7315
https://doi.org/10.1177/1087057113505905
https://doi.org/10.1177/1087057113505905
Autor:
Jermaine Ross, Kelley C. Larson, Sarah Kolitz, Thomas A. Miller, Michael Marconi, Matthew Ung, Barbara Tate, Jonathan M. Levenson, Lauren H. Martens, Rebecca Kusko, Rob Nunes, Ben Zeskind, Christopher D. Dejesus
Publikováno v:
Alzheimer's & Dementia. 15:P947-P947
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec8270d7b0ba3a23ddc13237fc3766c
https://doi.org/10.1016/j.jalz.2019.06.3082
https://doi.org/10.1016/j.jalz.2019.06.3082