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pro vyhledávání: '"Jonathan M. Kirby"'
Publikováno v:
The Febs Journal
Clostridium difficile is a burden to healthcare systems around the world, causing tens of thousands of deaths annually. The S‐layer of the bacterium, a layer of protein found of the surface of cells, has received a significant amount of attention o
Autor:
April K. Roberts, Clifford C. Shone, Zoë N. Freeman, Vivek Kumar, Jonathan M. Kirby, Helen Ahern, K. Ravi Acharya
Publikováno v:
Journal of Biological Chemistry. 284:34666-34673
Clostridium difficile is a major and growing problem as a hospital-associated infection that can cause severe, recurrent diarrhea. The mechanism by which the bacterium colonizes the gut during infection is poorly understood but undoubtedly involves p
Autor:
April K. Roberts, Jonathan M. Kirby, Nethaji Thiyagarajan, K. Ravi Acharya, Clifford C. Shone
Publikováno v:
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Cwp19 is a putatively surface-located protein from Clostridium difficile. A recombinant N-terminal protein (residues 27–401) lacking the signal peptide and the C-terminal cell-wall-binding repeats (PFam04122) was crystallized using the sitting-drop