Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jonathan M. J. Derry"'
Autor:
Kenneth R. Gundle, Karthik Rajasekaran, Jeffrey Houlton, Gary B. Deutsch, Thomas J. Ow, Robert G. Maki, John Pang, Cherie-Ann O. Nathan, Daniel Clayburgh, Jason G. Newman, Elyse Brinkmann, Michael J. Wagner, Seth M. Pollack, Matthew J. Thompson, Ryan J. Li, Vikas Mehta, Bradley A. Schiff, Barry I. Wenig, Paul L. Swiecicki, Alice L. Tang, Jessica L. Davis, Annemieke van Zante, Jessica A. Bertout, Wendy Jenkins, Atticus Turner, Marc Grenley, Connor Burns, Jason P. Frazier, Angela Merrell, Kimberly H. W. Sottero, Jonathan M. J. Derry, Kate C. Gillespie, Bre Mills, Richard A. Klinghoffer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Drug development is systemically inefficient. Research and development costs for novel therapeutics average hundreds of millions to billions of dollars, with the overall likelihood of approval estimated to be as low as 6.7% for oncology
Externí odkaz:
https://doaj.org/article/df356ddd88154387999a5c867f337370
Autor:
Bernardo V. Alvarez, Marilyse Piché, Carolin Aizouki, Fariha Rahman, Jonathan M. J. Derry, Isabelle Brunette, Joseph R. Casey
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract SLC4A11 is a H+/NH3/water transport protein, of corneal endothelial cells. SLC4A11 mutations cause congenital hereditary endothelial dystrophy and some cases of Fuchs endothelial corneal dystrophy. To probe SLC4A11’s roles, we compared gen
Externí odkaz:
https://doaj.org/article/907735515c4b45798e4cb3d6ef644a2f
Autor:
Joseph R. Casey, Bernardo V. Alvarez, Jonathan M. J. Derry, Fariha Rahman, Isabelle Brunette, Carolin Aizouki, Marilyse Piché
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
SLC4A11 is a H+/NH3/water transport protein, of corneal endothelial cells. SLC4A11 mutations cause congenital hereditary endothelial dystrophy and some cases of Fuchs endothelial corneal dystrophy. To probe SLC4A11’s roles, we compared gene express
Autor:
Jonathan M J Derry, Hua Zhong, Cliona Molony, Doug MacNeil, Debraj Guhathakurta, Bin Zhang, John Mudgett, Kersten Small, Lahcen El Fertak, Alain Guimond, Mohammed Selloum, Wenqing Zhao, Marie France Champy, Laurent Monassier, Tom Vogt, Doris Cully, Andrew Kasarskis, Eric E Schadt
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14319 (2010)
To identify the genes and pathways that underlie cardiovascular and metabolic phenotypes we performed an integrated analysis of a mouse C57BL/6JxA/J F2 (B6AF2) cross by relating genome-wide gene expression data from adipose, kidney, and liver tissues
Externí odkaz:
https://doaj.org/article/23109584e0dd4c9fb6b31af9555b8d4c
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(11)
Autor:
James D. Johnson, Thomas Reinbothe, Joshua Millstein, Anna Wendt, Sonja Hänzelmann, Sofia Salö, Jinling Wang, Malin Fex, Hindrik Mulder, Annika Bagge, Taman Mahdi, B Mecham, Xia Yang, Anders Rosengren, Tania Singh, Peter Spégel, Ivan G. Costa, Eduardo G. Gusmao, Jonathan M. J. Derry, Enming Zhang, Claes B. Wollheim, Lena Eliasson, Bin Zhang, Le Shu, Isabella Artner, Annika S. Axelsson, M Szabat, Hannah Nenonen, Yunzhao Tang
Publikováno v:
Nature Communications, Vol. 8 (2017) P. 15652
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications 8, 15652 (2017). doi:10.1038/ncomms15652
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications 8, 15652 (2017). doi:10.1038/ncomms15652
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for
Autor:
Stephen H. Friend, Brian Dougherty, Robert McEwen, Gilles Manceau, Pierre Laurent-Puig, Justin Guinney, Jonathan R. Dry, Erich Huang, Jean-Charles Soria, Michel Ducreux, Kai-Ming Chang, Jonathan M. J. Derry, KJ Kao, Charles Ferté, Kevin Hudson, Claus Bendtsen
Publikováno v:
Clinical Cancer Research. 20:265-272
Purpose: KRAS wild-type status is an imperfect predictor of sensitivity to anti-EGF receptor (EGFR) monoclonal antibodies in colorectal cancer, motivating efforts to identify novel molecular aberrations driving RAS. This study aimed to build a quanti
Autor:
Heribert Schunkert, Roby Joehanes, Ruth McPherson, Jonathan M. J. Derry, Tianxiao Huan, Christopher J. O'Donnell, Zhi Wang, Jun Zhu, Nalini Raghavachari, Paul Courchesne, Richard J. Wang, Xia Yang, Bin Zhang, Shih-Jen Hwang, Nilesh J. Samani, Qingying Meng, Saixia Ying, Christine Suver, Themistocles L. Assimes, Poching Liu, Peter J. Munson, Daniel Levy, Andrew D. Johnson
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:1427-1434
Objective— Genetic approaches have identified numerous loci associated with coronary heart disease (CHD). The molecular mechanisms underlying CHD gene–disease associations, however, remain unclear. We hypothesized that genetic variants with both
Autor:
Jed W. Fahey, Nils Wierup, Annika S. Axelsson, Shaji Chacko, Brig Mecham, Anders Rosengren, Hannah Nenonen, Jonathan M. J. Derry, Yunzhao Tang, Claes B. Wollheim, Emily Tubbs, Stephen H. Friend, Morey W. Haymond, Hindrik Mulder
Publikováno v:
Science Translational Medicine, Vol. 9, No 394 (2017)
A potentially useful approach for drug discovery is to connect gene expression profiles of disease-affected tissues ("disease signatures") to drug signatures, but it remains to be shown whether it can be used to identify clinically relevant treatment
Autor:
Keisuke Hirai, Joseph D. Buxbaum, Robin Kramer, Li Xie, Kristen K. Dang, Kathryn Roeder, Towfique Raj, Barbara K. Lipska, Shaun Purcell, Lambertus Klei, Panos Roussos, John F. Fullard, Vahram Haroutonian, A. Ercument Cicek, Konrad Talbot, Raquel E. Gur, Solveig K. Sieberts, Scott E. Hemby, Leslie A. Shinobu, Jun Zhu, Mette A. Peters, Pamela Sklar, Kristen J. Brennand, Aaron Topol, David A. Lewis, Mahsa Parvisi, Chang-Gyu Hahn, Ying-Chih Wang, Menachem Fromer, Nicholas Katsanis, Jessica S. Johnson, David A. Bennett, Andrew W. Browne, Zeynep H. Gümüş, Jonathan M. J. Derry, Ben Readhead, Edwin C. Oh, Benjamin A. Logsdon, Dalila Pinto, Cong Lu, David H. Kavanagh, Eli A. Stahl, Lara M. Mangravite, Enrico Domenici, Thanneer M. Perumal, Milind Mahajan, Douglas M. Ruderfer, Philip L. De Jager, Patrick F. Sullivan, Hiroyoshi Toyoshiba, Hardik Shah, Andrew Chess, Bin Zhang, Bernie Devlin, Joel T. Dudley, Tymor Hamamsy, Eric E. Schadt
Over 100 genetic loci harbor schizophrenia associated variants, yet how these common variants confer risk is uncertain. The CommonMind Consortium has sequenced dorsolateral prefrontal cortex RNA from schizophrenia cases (n=258) and control subjects (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08d72b0f3ac51e7b3a9ec731cc826bc
https://doi.org/10.1101/052209
https://doi.org/10.1101/052209