Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jonathan M. Harnoss"'
Autor:
Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M. Harnoss, David A. Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D. Wu, Peter Walter, Avi Ashkenazi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD). Here the authors discover a more promiscuous IRE1 activity dubbed RIDD lacking endomotif (RIDDLE)
Externí odkaz:
https://doaj.org/article/bef46ea29dad4d2bbd29966c9a96665b
Autor:
Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel disease (IBD). HIF-prolyl hydroxylases (PHD1, PHD2, and PHD3) control cellular adaptation to hypoxia and are considered promising therapeutic targets in IBD. Ho
Externí odkaz:
https://doaj.org/article/a20876b916204a5480cf7df3a59468fb
Autor:
Moritz J. Strowitzki, Gwendolyn Kimmer, Julian Wehrmann, Alina S. Ritter, Praveen Radhakrishnan, Vanessa M. Opitz, Christopher Tuffs, Marvin Biller, Julia Kugler, Ulrich Keppler, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt, Alfonso Blanco, Cormac T. Taylor, Martin Schneider
Publikováno v:
JCI Insight, Vol 6, Iss 8 (2021)
Anastomotic leakage (AL) accounts for a major part of in-house mortality in patients undergoing colorectal surgery. Local ischemia and abdominal sepsis are common risk factors contributing to AL and are characterized by upregulation of the hypoxia-in
Externí odkaz:
https://doaj.org/article/76b029c8965e460eac6d2501514203de
Autor:
Moritz J. Strowitzki, Alina S. Ritter, Praveen Radhakrishnan, Jonathan M. Harnoss, Vanessa M. Opitz, Marvin Biller, Julian Wehrmann, Ulrich Keppler, Jana Scheer, Markus Wallwiener, Thomas Schmidt, Alexis Ulrich, Martin Schneider
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Peritoneal adhesions represent a common complication of abdominal surgery, and tissue hypoxia is a main determinant in adhesion formation. Reliable therapeutic options to reduce peritoneal adhesions are scarce. We investigated whether the fo
Externí odkaz:
https://doaj.org/article/43eac480f7274873bf568b3a53b3ff8a
Autor:
Anna Shemorry, Jonathan M Harnoss, Ofer Guttman, Scot A Marsters, László G Kőműves, David A Lawrence, Avi Ashkenazi
Publikováno v:
eLife, Vol 8 (2019)
Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the cell to apoptotic death. Here we show that in hem
Externí odkaz:
https://doaj.org/article/447fe82d1b704055b7ba75eb3ece6428
Autor:
Avi Ashkenazi, Peter Walter, Hartmut Koeppen, Joachim Rudolph, Zora Modrusan, Margaret Solon, Monika Dohse, Kathryn Mesh, Lisa M. Crocker, Klara Totpal, Mark Merchant, Ehud Segal, David Kan, David A. Lawrence, Anna Shemorry, Scot A. Marsters, Thomas D. Wu, Ofer Guttman, Mike Reichelt, Adrien Le Thomas, Jonathan M. Harnoss
Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic reticulum (ER) stress caused by cellular oncogene activation and a hostile tumor microenvironment (TME). The key UPR sensor IRE1α resides in the ER and deploys a cytopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f449b5b365bd1638a42e0af1a7c7a357
https://doi.org/10.1158/0008-5472.c.6511463.v1
https://doi.org/10.1158/0008-5472.c.6511463.v1
Autor:
Avi Ashkenazi, Peter Walter, Hartmut Koeppen, Joachim Rudolph, Zora Modrusan, Margaret Solon, Monika Dohse, Kathryn Mesh, Lisa M. Crocker, Klara Totpal, Mark Merchant, Ehud Segal, David Kan, David A. Lawrence, Anna Shemorry, Scot A. Marsters, Thomas D. Wu, Ofer Guttman, Mike Reichelt, Adrien Le Thomas, Jonathan M. Harnoss
Supplementary Data, including Supplementary Materials and Methods, References for Supplementary Data, and Figs. S1 to S5 including Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2debaf8226a89d41e2b51ea1e40f553d
https://doi.org/10.1158/0008-5472.22423295
https://doi.org/10.1158/0008-5472.22423295
Autor:
Marvin L Biller, Christopher Tuffs, Marc Bleul, Dinh Thien-An Tran, Mareen Dupovac, Ulrich Keppler, Jonathan M Harnoss, Pascal Probst, Martin Schneider, Moritz J Strowitzki
Publikováno v:
Journal of the American College of Surgeons. 234:1167-1180
Peritoneal adhesion formation is common after abdominal surgery and results in severe complications. Tissue hypoxia is one of the main drivers of peritoneal adhesions. Thus, we determined the clinical role of hypoxia-inducible factor (HIF)-1 signalin
Autor:
Jonathan M. Harnoss, Jun Cai, Sascha Hinterkopf, Praveen Radhakrishnan, Annabelle Schmitt, Mareen Dupovac, Lisa K. Nees, Moritz J. Strowitzki, Cormac T. Taylor, Martin Schneider
Publikováno v:
Transplantation. 106(10)
Ischemia and reperfusion injury (IRI) determines primary allograft function after liver transplantation (LT). Primary graft dysfunction (PGD) is associated with increased morbidity and impaired graft survival and can eventually progress to graft fail
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Autor:
Ofer Guttman, Adrien Le Thomas, Scot Marsters, David A. Lawrence, Lauren Gutgesell, Iratxe Zuazo-Gaztelu, Jonathan M. Harnoss, Simone M. Haag, Aditya Murthy, Geraldine Strasser, Zora Modrusan, Thomas Wu, Ira Mellman, Avi Ashkenazi
Publikováno v:
The Journal of cell biology. 221(6)
Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8+ T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER), bind to major histocompatibility type I (MH