Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan M. Haldeman"'
Autor:
Liora S. Katz, Gabriel Brill, Peng Wang, Luca Lambertini, Pili Zhang, Jonathan M. Haldeman, Hongtao Liu, Christopher B. Newgard, Andrew F. Stewart, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101848- (2024)
Objective: All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding of how β-cells proliferate. Glucose is a natural β-cell mi
Externí odkaz:
https://doaj.org/article/ca3bb72876334491840e4095754b390d
Autor:
Ashot Sargsyan, Ludivine Doridot, Sarah A. Hannou, Wenxin Tong, Harini Srinivasan, Rachael Ivison, Ruby Monn, Henry H. Kou, Jonathan M. Haldeman, Michelle Arlotto, Phillip J. White, Paul A. Grimsrud, Inna Astapova, Linus T. Tsai, Mark A. Herman
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Carbohydrate response element–binding protein (ChREBP) is a carbohydrate-sensing transcription factor that regulates both adaptive and maladaptive genomic responses in coordination of systemic fuel homeostasis. Genetic variants in the ChREBP locus
Externí odkaz:
https://doaj.org/article/ade443ac94814a119908baff8633073d
Autor:
Heather L Hayes, Brett S Peterson, Jonathan M Haldeman, Christopher B Newgard, Hans E Hohmeier, Samuel B Stephens
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172567 (2017)
Increased β-cell death coupled with the inability to replicate existing β-cells drives the decline in β-cell mass observed in the progression of both major forms of diabetes. Understanding endogenous mechanisms of islet cell survival could have co
Externí odkaz:
https://doaj.org/article/d70e914937334dbda3ba6b58138db9f6
Autor:
Michelle Arlotto, Henry H. Kou, Linus Tsai, Harini Srinivasan, Paul A. Grimsrud, Wenxin Tong, Phillip J. White, Ludivine Doridot, Ashot Sargsyan, Rachael Ivison, Jonathan M. Haldeman, Sarah A. Hannou, Ruby Monn, Inna Astapova, Mark A. Herman
Carbohydrate Responsive Element-Binding Protein (ChREBP) is a carbohydrate sensing transcription factor that regulates both adaptive and maladaptive genomic responses in coordination of systemic fuel homeostasis. Genetic variants in the ChREBP locus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e70abd7c41ae7e505be5d9d7fb978e7
https://doi.org/10.1101/2021.07.29.454308
https://doi.org/10.1101/2021.07.29.454308
Autor:
Wenxin Tong, Harini Srinivasan, Jonathan M. Haldeman, Linus Tsai, Ludivine Doridot, Ashot Sargsyan, Rachael Ivison, Sarah A. Hannou, Ruby Monn, Inna Astapova, Henry H. Kou, Mark A. Herman
Publikováno v:
Diabetes. 70
Carbohydrate Responsive Element-Binding Protein (ChREBP) is a carbohydrate sensing transcription factor that regulates metabolic gene programs. Genetic variants in the ChREBP locus associate with diverse metabolic traits in humans, including circulat
Autor:
Svetha Swaminathan, Samuel B. Stephens, Jonathan M. Haldeman, McKenzie Becker, Casey J. Bauchle, Shelby C. Bearrows
Publikováno v:
J Cell Sci
Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core secretory granules of multiple endocrine tissues and has been suggested to regulate granule biogenesis in some cell types, including the pancreatic islet β-cell, though t
Autor:
Patrick E. MacDonald, Jonathan M. Haldeman, Jonathan E. Campbell, Sophie L. Lewandowski, Matthew J. Merrins, David A. D'Alessio, Megan E. Capozzi, Haopeng Lin, Justin L. Jaffe, Berit Svendsen, Reilly W. Coch, Mackenzie D. Martin, Sara E. Encisco
Publikováno v:
JCI insight. 4(5)
Paracrine interactions between pancreatic islet cells have been proposed as a mechanism to regulate hormone secretion and glucose homeostasis. Here, we demonstrate the importance of proglucagon-derived peptides (PGDPs) for α to β cell communication
Autor:
Guo-Fang Zhang, Christopher B. Newgard, Paul A. Grimsrud, David T. Chuang, Michelle Arlotto, Olga Ilkayeva, Richard M. Wynn, Phillip J. White, Jonathan M. Haldeman, Robert W. McGarrah, Wen-Hsuan Yang
Publikováno v:
Diabetes. 67
Strong associations exist between branched chain amino acids (BCAA) and dysregulated glucose and lipid metabolism, but underlying mechanisms are not well understood. One factor contributing to elevated BCAA in obesity is inhibitory phosphorylation of
Autor:
Thomas E. Hughes, Robert Stevens, Deborah M. Muoio, James R. Bain, Erin L. Glynn, Christopher B. Newgard, Jeffrey I. Gordon, Liping Wang, Vanessa K. Ridaura, Scott A. Summers, Steven A. Thomas, Olga Ilkayeva, Michael J. Muehlbauer, Jie An, Michael L. Patnode, Jonathan M. Haldeman, James E. Vath
Publikováno v:
JCI Insight, Vol 3, Iss 5 (2018)
Current obesity interventions suffer from lack of durable effects and undesirable complications. Fumagillin, an inhibitor of methionine aminopeptidase-2, causes weight loss by reducing food intake, but with effects on weight that are superior to pair
Publikováno v:
Leukemia
The leukemogenic CALM-AF10 fusion protein is found in patients with immature acute myeloid and T-lymphoid malignancies. CALM-AF10 leukemias display abnormal H3K79 methylation and increased HOXA cluster gene transcription. Elevated expression of HOXA