Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Jonathan M. Gerrard"'
Publikováno v:
Platelets. 2(4)
SUMMARY. The role of intracellular histamine in the activation of human platelets was explored using the novel histamine antagonist N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE). DPPE inhibited aggregation, [(32)P]-phosphatidic acid produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9546a8bac1a9c0f051cc32f9c1ffa60
https://pubmed.ncbi.nlm.nih.gov/21043931
https://pubmed.ncbi.nlm.nih.gov/21043931
Publikováno v:
Blood. 80:718-723
The dense tubular system (DTS) functions to regulate platelet activation by sequestering or releasing calcium, similar to the sarcotubules of skeletal muscle. In resting platelets, the DTS exists as thin elongated membranes. Within 10 seconds of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fe51db0d3b7a494ee3d2ec557909b6
https://doi.org/10.1182/blood.v80.3.718.718
https://doi.org/10.1182/blood.v80.3.718.718
Publikováno v:
Biochemical Journal. 273:405-408
In previous reports, we have provided evidence indicating that newly formed histamine is an intracellular messenger in human platelets. The involvement of protein kinase C (PKC) and intracellular calcium (Ca2+i) in the synthesis of histamine was inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949332e6da6ccff2b72ba86b4204016a
https://doi.org/10.1042/bj2730405
https://doi.org/10.1042/bj2730405
Autor:
Eileen M Mcmillan, Catherine Robertson, Jonathan M. Gerrard, Peter J. Sims, Therese Wiedmer, RD Fugate, D Lint, Sara J. Israels
Publikováno v:
Blood. 77:101-112
Monoclonal antibodies were raised after injecting mice with isolated human dense granules. Several of these monoclonals were found to recognize a 40-Kd dense granule membrane protein. Western blot and immunofluorescent analysis confirmed the dense-gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1873cc2d5ec0b6d5592defa81f0cd10
https://doi.org/10.1182/blood.v77.1.101.bloodjournal771101
https://doi.org/10.1182/blood.v77.1.101.bloodjournal771101
Publikováno v:
Blood. 75:407-414
We previously demonstrated that newly formed intracellular histamine mediates platelet aggregation in response to phorbol-12-myristate-13- acetate (PMA). We now report further investigations of the role of histamine during physiological activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f62ea078c14b835362cd4f9c863eb693
https://doi.org/10.1182/blood.v75.2.407.407
https://doi.org/10.1182/blood.v75.2.407.407
Possible mechanisms of epinephrine actions in quin-2-loaded platelets refractory to arachidonic acid
Publikováno v:
Biochemical medicine and metabolic biology. 50(3)
We evaluated the effect of Quin-2 loading (20 microM) on platelet responses such as phosphoinositide turnover, elevation of cytosolic Ca2+, phosphorylation of myosin light chain (MLC) and a 47-kDa protein, and aggregation in human platelets stimulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4114bf24229d8e959b79749475f5ae
https://pubmed.ncbi.nlm.nih.gov/8123296
https://pubmed.ncbi.nlm.nih.gov/8123296
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461363040
The fusion of cells from mouse and man to produce functional hybrids, first shown by Henry Harris in 1965 (Hams and Watkins, 1965) and since duplicated using many different cell types, has emphasized the remarkable consistency and similarity in the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5afac9c3866d6ab4caeecdff6c6218fc
https://doi.org/10.1007/978-1-4615-2994-1_16
https://doi.org/10.1007/978-1-4615-2994-1_16
Autor:
Masahiro Nishibori, Archibald McNicol, Sara J. Israels, Jonathan M. Gerrard, Bonnie Cham, YV Jacques, DF Bainton
Publikováno v:
Blood. 80(1)
We recently reported the characterization of a platelet granule membrane protein of molecular weight (mol wt) 40,000 called granulophysin (Gerrard et al: Blood 77:101, 1991), identified by a monoclonal antibody (MoAb D545) raised to purified dense gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afa85adc1a33c5cd748de0edf877abe
https://pubmed.ncbi.nlm.nih.gov/1377048
https://pubmed.ncbi.nlm.nih.gov/1377048
Publikováno v:
Journal of Pediatric Hematology/Oncology. 13:102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3594b7f97a18b8f38693e53e00af7f0c
https://doi.org/10.1097/00043426-199121000-00035
https://doi.org/10.1097/00043426-199121000-00035
Autor:
Jonathan M. Gerrard
Publikováno v:
Hospital Practice. 23:89-108
The hemostatic functions of the platelet depend in a large part on adhesion and aggregation processes. Both the proteins that mediate the adhesive processes and their cellular binding sites have been identified, with much information derived from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5890396353c8f5abeaa1e4166a31ac
https://doi.org/10.1080/21548331.1988.11703404
https://doi.org/10.1080/21548331.1988.11703404