Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan M. DeLiberty"'
Autor:
Channing J. Der, Adrienne D. Cox, Udo Rudloff, Krister Wennerberg, Brian M. Wolpin, Andrew J. Aguirre, Dhirendra K. Simanshu, Emanuel F. Petricoin, Sharon L. Campbell, Dominic Esposito, Kirsten L. Bryant, Prson Gautam, Raymond W.S. Ng, Junning Wang, Jonathan M. DeLiberty, Craig M. Goodwin, Jennifer E. Klomp, Richard G. Hodge, Bjoern Papke, J. Nathaniel Diehl, Andrew M. Waters, Andrew O. Anderson, Timothy H. Tran, Mariaelena Pierobon, Ryan D. Thurman, Anne M. Miermont, Nicole M. Baker, G. Aaron Hobbs
All supplemental data with figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af433484762ea35ed3daf8e992a67bb1
https://doi.org/10.1158/2159-8290.22535653.v1
https://doi.org/10.1158/2159-8290.22535653.v1
Autor:
Channing J. Der, Adrienne D. Cox, Udo Rudloff, Krister Wennerberg, Brian M. Wolpin, Andrew J. Aguirre, Dhirendra K. Simanshu, Emanuel F. Petricoin, Sharon L. Campbell, Dominic Esposito, Kirsten L. Bryant, Prson Gautam, Raymond W.S. Ng, Junning Wang, Jonathan M. DeLiberty, Craig M. Goodwin, Jennifer E. Klomp, Richard G. Hodge, Bjoern Papke, J. Nathaniel Diehl, Andrew M. Waters, Andrew O. Anderson, Timothy H. Tran, Mariaelena Pierobon, Ryan D. Thurman, Anne M. Miermont, Nicole M. Baker, G. Aaron Hobbs
Structure factors and crystal information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216f6e8c4cf83b25972bc99b461169ca
https://doi.org/10.1158/2159-8290.22535650
https://doi.org/10.1158/2159-8290.22535650
Autor:
Kirsten L. Bryant, Stephen D. Hursting, Channing J. Der, Adrienne D. Cox, Krister Wennerberg, Prson Gautam, Emanuel F. Petricoin, Mariaelena Pierobon, Craig M. Goodwin, Björn Papke, Jonathan M. DeLiberty, Runying Yang, Michael F. Coleman, A. Cole Edwards, Kajal R. Grover, Clint A. Stalnecker
Supplementary Figure from Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163c0671121a747c0511762384eaab20
https://doi.org/10.1158/0008-5472.22431325.v1
https://doi.org/10.1158/0008-5472.22431325.v1
Autor:
Kirsten L. Bryant, Stephen D. Hursting, Channing J. Der, Adrienne D. Cox, Krister Wennerberg, Prson Gautam, Emanuel F. Petricoin, Mariaelena Pierobon, Craig M. Goodwin, Björn Papke, Jonathan M. DeLiberty, Runying Yang, Michael F. Coleman, A. Cole Edwards, Kajal R. Grover, Clint A. Stalnecker
The aggressive nature of pancreatic ductal adenocarcinoma (PDAC) mandates the development of improved therapies. As KRAS mutations are found in 95% of PDAC and are critical for tumor maintenance, one promising strategy involves exploiting KRAS-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe92f59ec4caa6cc2e5657a516fd0f49
https://doi.org/10.1158/0008-5472.c.6513874.v1
https://doi.org/10.1158/0008-5472.c.6513874.v1
Autor:
Minh V, Huynh, G Aaron, Hobbs, Antje, Schaefer, Mariaelena, Pierobon, Leiah M, Carey, J Nathaniel, Diehl, Jonathan M, DeLiberty, Ryan D, Thurman, Adelaide R, Cooke, Craig M, Goodwin, Joshua H, Cook, Lin, Lin, Andrew M, Waters, Naim U, Rashid, Emanuel F, Petricoin, Sharon L, Campbell, Kevin M, Haigis, Diane M, Simeone, Costas A, Lyssiotis, Adrienne D, Cox, Channing J, Der
Publikováno v:
Sci Signal
Although oncogenic driver mutations in RAS occur in 20% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science Signaling, Huynh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::902a36258802379ec4087c4e0daa0e25
https://pubmed.ncbi.nlm.nih.gov/35944067
https://pubmed.ncbi.nlm.nih.gov/35944067
Autor:
Jonathan M. DeLiberty, Clint A. Stalnecker, Kristina Drizyte-Miller, Elyse G. Schechter, Noah L. Pieper, Runying Yang, Channing J. Der, Adrienne D. Cox, Kirsten L. Bryant
Publikováno v:
Cancer Research. 83:4851-4851
Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent growth. We and others recently demonstrated that inhibition of the RAF-MEK-ERK pathway resulted in upregulated autophagy, and that dual treatment with the autop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28656c8ff9e627511f3e068eb2736be
https://doi.org/10.1158/1538-7445.am2023-4851
https://doi.org/10.1158/1538-7445.am2023-4851
Autor:
Minh V. Huynh, G. Aaron Hobbs, Antje Schaefer, Mariaelena Pierobon, Leiah M. Carey, J. Nathaniel Diehl, Jonathan M. DeLiberty, Ryan D. Thurman, Adelaide R. Cooke, Craig M. Goodwin, Joshua H. Cook, Lin Lin, Andrew M. Waters, Naim U. Rashid, Emanuel F. Petricoin, Sharon L. Campbell, Kevin M. Haigis, Diane M. Simeone, Costas A. Lyssiotis, Adrienne D. Cox, Channing J. Der
Publikováno v:
Science Signaling. 15
Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS—Gly 12 , Gly 13 , and Gln 61 (commonly known as G12, G13, and Q61, respectively)—occur differentially among the three RAS isoforms. Q61 mutations in KRAS are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a3b4c161cea4d936e027bb855de402
https://doi.org/10.1126/scisignal.abn2694
https://doi.org/10.1126/scisignal.abn2694
Autor:
Jonathan M. DeLiberty, Ryan Robb, Claire E. Gates, Noah L. Pieper, Runying Yang, Clint A. Stalnecker, Kirsten L. Bryant
Publikováno v:
Cancer Research. 82:B007-B007
Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent tumorigenic growth. We determined the role of mutationally activated KRAS, found in ~95% of PDAC, in supporting autophagy. Surprisingly, acute KRAS suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::110fee71dead03f24c05cbf5b8d9e089
https://doi.org/10.1158/1538-7445.panca22-b007
https://doi.org/10.1158/1538-7445.panca22-b007
Autor:
Reet Pai, Lin Zhang, Yi-Jun Wang, Jian Yu, Robert L. Ferris, Jingshan Tong, Brian J. Leibowitz, Rochelle Fletcher, Donna B. Stolz, Robert E. Schoen, Denise Risnik, Fernando Concha-Benavente, Jonathan M. DeLiberty
Publikováno v:
Oncogene
Use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with reduced risk of colorectal cancer (CRC). However, the mechanism by which NSAIDs suppress colorectal tumorigenesis remains unclear. We previously showed that NSAIDs selectively k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c0845e49056ef3988ea2d6fcb797e2
http://europepmc.org/articles/PMC7981263
http://europepmc.org/articles/PMC7981263
Autor:
Udo Rudloff, J. Nathaniel Diehl, G. Aaron Hobbs, Emanuel F. Petricoin, Channing J. Der, Adrienne D. Cox, Raymond W.S. Ng, Kirsten L. Bryant, Mariaelena Pierobon, Nicole M. Baker, Andrew J. Aguirre, Richard G. Hodge, Timothy H. Tran, Junning Wang, Andrew O. Anderson, Dominic Esposito, Anne M. Miermont, Adele Waters, Craig M. Goodwin, Bjoern Papke, Krister Wennerberg, Jonathan M. DeLiberty, Sharon L. Campbell, Jennifer E. Klomp, Prson Gautam, Dhirendra K. Simanshu, Ryan D. Thurman, Brian M. Wolpin
Publikováno v:
Cancer Discovery. 10:104-123
Allele-specific signaling by different KRAS alleles remains poorly understood. The KRASG12R mutation displays uneven prevalence among cancers that harbor the highest occurrence of KRAS mutations: It is rare (∼1%) in lung and colorectal cancers, yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa82b314b3e4ec599833f58d2c271e56
https://doi.org/10.1158/2159-8290.cd-19-1006
https://doi.org/10.1158/2159-8290.cd-19-1006