Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jonathan M. Clingan"'
Autor:
Frank W Soveg, Johannes Schwerk, Nandan S Gokhale, Karen Cerosaletti, Julian R Smith, Erola Pairo-Castineira, Alison M Kell, Adriana Forero, Shivam A Zaver, Katharina Esser-Nobis, Justin A Roby, Tien-Ying Hsiang, Snehal Ozarkar, Jonathan M Clingan, Eileen T McAnarney, Amy EL Stone, Uma Malhotra, Cate Speake, Joseph Perez, Chiraag Balu, Eric J Allenspach, Jennifer L Hyde, Vineet D Menachery, Saumendra N Sarkar, Joshua J Woodward, Daniel B Stetson, John Kenneth Baillie, Jane H Buckner, Michael Gale Jr, Ram Savan
Publikováno v:
eLife, Vol 10 (2021)
Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields
Externí odkaz:
https://doaj.org/article/3265b04191644b45bacaf4c20c760cca
Autor:
Michael Gale, Ram Savan, Alison M. Kell, Eileen T. McAnarney, Vineet D. Menachery, Cate Speake, Daniel B. Stetson, Saumendra N. Sarkar, Frank Soveg, Katharina Esser-Nobis, Nandan S. Gokhale, Jennifer L. Hyde, Chiraag Balu, Jane H. Buckner, Justin A Roby, Julian R. Smith, Erola Pairo-Castineira, Snehal Ozarkar, Johannes Schwerk, Karen Cerosaletti, Shivam A. Zaver, J K Baillie, Amy E. L. Stone, Tien-Ying Hsiang, Jonathan M. Clingan, Joseph Perez, Adriana Forero, Eric J. Allenspach, Joshua J. Woodward, Uma Malhotra
Publikováno v:
Soveg, F W, Schwerk, J, Gokhale, N S, Cerosaletti, K, Smith, J R, Pairo-Castineira, E, Kell, A M, Forero, A, Zaver, S A, Esser-Nobis, K, Roby, J A, Hsiang, T-Y, Ozarkar, S, Clingan, J M, McAnarney, E T, Stone, A E, Malhotra, U, Speake, C, Perez, J, Balu, C, Allenspach, E J, Hyde, J L, Menachery, V D, Sarkar, S N, Woodward, J J, Stetson, D B, Baillie, J K, Buckner, J H, Gale, M & Savan, R 2021, ' Endomembrane targeting of human OAS1 p46 augments antiviral activity ', eLIFE, vol. 10 . https://doi.org/10.7554/eLife.71047
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5956754d0a3f58caee9c5ba3381ec8cb
https://hdl.handle.net/20.500.11820/c65fe5ea-4f46-4848-978a-9787d0d5b4ce
https://hdl.handle.net/20.500.11820/c65fe5ea-4f46-4848-978a-9787d0d5b4ce
Autor:
Eric J. Allenspach, Joshua J. Woodward, Nandan S. Gokhale, Jennifer L. Hyde, Karen Cerosaletti, Joseph Perez, Snehal Ozarkar, Jonathan M. Clingan, Saumendra N. Sarkar, Michael Gale, Justin A Roby, Shivam A. Zaver, Ram Savan, Alison M. Kell, Erola Pairo-Castineira, Adriana Forero, Eileen T. McAnarney, J Kenneth Baillie, Frank Soveg, Chiraag Balu, Jane H. Buckner, Uma Malhotra, Vineet D. Menachery, Cate Speake, Tien-Ying Hsiang, Daniel B. Stetson, Katharina Esser-Nobis, Johannes Schwerk, Amy E. L. Stone, Julian R. Smith
SUMMARYMany host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b59d9d71a19dc95c6e0fb997ea77217
https://doi.org/10.1101/2021.04.21.440697
https://doi.org/10.1101/2021.04.21.440697
Autor:
Jonathan M. Clingan, Kristin M. Ostrow, Karoline A. Hosiawa, Mehrdad Matloubian, Zhijian J. Chen
Publikováno v:
The Journal of Immunology. 188:4432-4440
The necessity for pathogen recognition of viral infection by the innate immune system in initiating early innate and adaptive host defenses is well documented. However, little is known about the role these receptors play in the maintenance of adaptiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7082febfca09ddc5f91c8d0735acd430
https://doi.org/10.4049/jimmunol.1103656
https://doi.org/10.4049/jimmunol.1103656
Autor:
Arthur Weiss, Mehrdad Matloubian, Joseph Schlessinger, Hyewon Phee, Sören Beinke, Jonathan M. Clingan
Publikováno v:
Proceedings of the National Academy of Sciences. 107:16234-16239
T-cell interactions with antigen-presenting cells are important for CD8 T-cell effector or memory fate determination. The integrin leukocyte function-associated antigen-1 (LFA-1) mediates T-cell adhesion but the contribution of LFA-1–induced signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb59115fa1af4eec9eed7c4b0dfc4a9
https://doi.org/10.1073/pnas.1011556107
https://doi.org/10.1073/pnas.1011556107
Publikováno v:
International Immunology. 17:1201-1212
c-Jun N-terminal kinase (JNK) is generally thought to be involved in inflammation, proliferation and apoptosis. However, functional role(s) of this molecule in dendritic cells (DCs) has not been well understood. CCR7 ligands, CCL19 and CCL21, induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7c66600bff704f01dbc5a93f5e95fa
https://doi.org/10.1093/intimm/dxh297
https://doi.org/10.1093/intimm/dxh297
The importance for activation of innate immunity by pattern recognition receptors in forming an effective adaptive immune response is well known. TLRs were demonstrated to be critical for Ab responses to a variety of immunizations. In particular, rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23c2527024f5cb9eb186614659a1e3c
https://europepmc.org/articles/PMC3702634/
https://europepmc.org/articles/PMC3702634/
Autor:
Bruno Canard, Jay R. Hesselberth, Michael Gale, David J. Barton, Hilario J. Ramos, Jonathan M. Clingan, Daniel B. Stetson, Jaime Guillén, Sterling C Eckard, Daphne A. Cooper
Publikováno v:
Cancer Immunology Research. 4:B133-B133
Intracellular detection of RNA or DNA triggers distinct sensors that protect against virus infection: RNA activates the RIG-I-like Receptor (RLR)-MAVS pathway, whereas DNA activates the cyclic GMP-AMP Synthase (cGAS)-STING pathway. In addition, the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd4147c63f7ba34ca8d995a901459307
https://doi.org/10.1158/2326-6066.imm2016-b133
https://doi.org/10.1158/2326-6066.imm2016-b133
Publikováno v:
Proceedings of the National Academy of Sciences
Generation of a robust immunological memory response is essential for protection on subsequent encounters with the same pathogen. The magnitude and quality of the memory CD8 T-cell population are shaped and influenced by the strength and duration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345e3d723004766673bc6bb565ad3cc5
https://doi.org/10.1073/pnas.1101881108
https://doi.org/10.1073/pnas.1101881108
Publikováno v:
Cellular immunology. 242(2)
Effects of T helper 2 (Th2) and Th1 cytokines, interleukin (IL)-4, and interferon (IFN)-gamma, respectively, on chemokine-induced DC migration and endocytosis are not well understood. We investigated herein the effects of these cytokines on chemokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce688b38bb95e848c7eacd8e25eb203b
https://pubmed.ncbi.nlm.nih.gov/17098215
https://pubmed.ncbi.nlm.nih.gov/17098215