Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jonathan M Wilkes"'
Autor:
Federica Giordani, Daniel Paape, Isabel M Vincent, Andrew W Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J Morrison, Yvonne Freund, Michael J Witty, Rosemary Peter, Darren Y Edwards, Jonathan M Wilkes, Justin J J van der Hooft, Clément Regnault, Kevin D Read, David Horn, Mark C Field, Michael P Barrett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008932 (2020)
Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promis
Externí odkaz:
https://doaj.org/article/a5d1aac4a0fd47b29679ea476bd015f8
Autor:
Johannes Felix Stortz, Mario Del Rosario, Mirko Singer, Jonathan M Wilkes, Markus Meissner, Sujaan Das
Publikováno v:
eLife, Vol 8 (2019)
In addition to its role in erythrocyte invasion, Plasmodium falciparum actin is implicated in endocytosis, cytokinesis and inheritance of the chloroplast-like organelle called the apicoplast. Previously, the inability to visualise filamentous actin (
Externí odkaz:
https://doaj.org/article/e14157f79b7e4c07948af73c60e026d7
Autor:
Fernando Fernandez-Cortes, Tiago D. Serafim, Jonathan M. Wilkes, Nathaniel G. Jones, Ryan Ritchie, Richard McCulloch, Jeremy C. Mottram
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Protein kinases (PKs) are a class of druggable targets in Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (sleeping sickness), yet little is known about which PKs are essential for survival in mammals. A recent kinom
Externí odkaz:
https://doaj.org/article/f42ca3b4269e44a1a0bd4fab4c2527c1
Autor:
Eva Rico, Andrew W. Pountain, Isabel M. Vincent, Michael J. Witty, Michael P. Barrett, Fernando Fernandez-Cortes, Ning Zhang, Mark C. Field, David Horn, Jonathan M. Wilkes, Justin J. J. van der Hooft, Yvonne Freund, Darren Y. Edwards, Daniel Paape, Liam J. Morrison, Rosemary Peter, Clément Regnault, Federica Giordani, Kevin D. Read
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008932 (2020)
PLoS Pathogens
PLoS Pathogens, 16(11)
PLoS Pathogens 16 (2020) 11
Giordani, F, Paape, D, Vincent, I M, Pountain, A W, Fernandez-Cortes, F, Rico, E, Zhang, N, Morrison, L, Freund, Y, Witty, M J, Peter, R, Edwards, D, Wilkes, J, van der Hooft, J J J, Regnault, C, Read, K D, Horn, D, Field, M C & Barrett, M P 2020, ' Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs ', PLoS Pathogens, vol. 16, no. 11, e1008932 . https://doi.org/10.1371/journal.ppat.1008932
PLoS Pathogens
PLoS Pathogens, 16(11)
PLoS Pathogens 16 (2020) 11
Giordani, F, Paape, D, Vincent, I M, Pountain, A W, Fernandez-Cortes, F, Rico, E, Zhang, N, Morrison, L, Freund, Y, Witty, M J, Peter, R, Edwards, D, Wilkes, J, van der Hooft, J J J, Regnault, C, Read, K D, Horn, D, Field, M C & Barrett, M P 2020, ' Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs ', PLoS Pathogens, vol. 16, no. 11, e1008932 . https://doi.org/10.1371/journal.ppat.1008932
Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a3504630182edfb682742da45095c8
https://doaj.org/article/a5d1aac4a0fd47b29679ea476bd015f8
https://doaj.org/article/a5d1aac4a0fd47b29679ea476bd015f8
Pathogenic obligate-intracellular apicomplexan parasites possess an essential chloroplast-like organelle called the apicoplast that undergoes division and segregation during replication. Parasite actin is essential during intracellular development, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d87d7f6add39f80f35d6ff0f516d198
https://doi.org/10.1101/488528
https://doi.org/10.1101/488528
Autor:
David Horn, Tiago D. Serafim, Leandro Lemgruber, Emma Briggs, Graham Hamilton, Sam Alsford, Jonathan M. Wilkes, Richard McCulloch, Jeremy C. Mottram, Fernando Fernandez-Cortes, Jennifer A. Stortz
Publikováno v:
PLoS Pathogens
Stortz, J A, Serafim, T D, Alsford, S, Wilkes, J, Fernandez-Cortes, F, Hamilton, G, Briggs, E, Lemgruber, L, Horn, D, Mottram, J C & McCulloch, R 2017, ' Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei ', PLoS Pathogens, vol. 13, no. 7, e1006477 . https://doi.org/10.1371/journal.ppat.1006477
PLoS Pathogens, Vol 13, Iss 7, p e1006477 (2017)
Stortz, J A, Serafim, T D, Alsford, S, Wilkes, J, Fernandez-Cortes, F, Hamilton, G, Briggs, E, Lemgruber, L, Horn, D, Mottram, J C & McCulloch, R 2017, ' Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei ', PLoS Pathogens, vol. 13, no. 7, e1006477 . https://doi.org/10.1371/journal.ppat.1006477
PLoS Pathogens, Vol 13, Iss 7, p e1006477 (2017)
All cells are subject to structural damage that must be addressed for continued growth. A wide range of damage affects the genome, meaning multiple pathways have evolved to repair or bypass the resulting DNA lesions. Though many repair pathways are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df885123f471a77b4c1e60cdb042c18d
Autor:
Bruno Goddeeris, Julien Cauchard, Jonathan M. Wilkes, Kris Laukens, Hadush Birhanu, Jean-Claude Dujardin, Philippe Büscher, Bart Cuypers, Frederik Van den Broeck, Filip Claes, Nick Van Reet, Conor J. Meehan, Stijn Deborggraeve
Publikováno v:
Genome Biology and Evolution
Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and T. b. rhodesiense cause human African trypanosomiasis, while T. b. brucei, T. evansi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76072e01744caca5f4b544ff828b809
https://hdl.handle.net/10067/1432470151162165141
https://hdl.handle.net/10067/1432470151162165141
Publikováno v:
Molecular Microbiology. 81:434-456
Homologous recombination in Trypanosoma brucei is used for moving variant surface glycoprotein (VSG) genes into expression sites during immune evasion by antigenic variation. A major route for such VSG switching is gene conversion reactions in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57cce3c1fa5ac09caa120b9ba3eb2a5b
https://doi.org/10.1111/j.1365-2958.2011.07703.x
https://doi.org/10.1111/j.1365-2958.2011.07703.x
Publikováno v:
Molecular Microbiology. 79:205-221
Aurora kinases compose a family of conserved Ser/Thr protein kinases playing essential roles in eukaryotic cell division. To date, Aurora homologues remain uncharacterized in the protozoan phylum Apicomplexa. In malaria parasites, the characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb04d3a060268f6f0262e0589d1e9297
https://doi.org/10.1111/j.1365-2958.2010.07442.x
https://doi.org/10.1111/j.1365-2958.2010.07442.x