Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Jonathan M Weiss"'
Autor:
Arta M Monjazeb, Julia K Tietze, Steven K Grossenbacher, Hui-Hua Hsiao, Anthony E Zamora, Annie Mirsoian, Brent Koehn, Bruce R Blazar, Jonathan M Weiss, Robert H Wiltrout, Gail D Sckisel, William J Murphy
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e102709 (2014)
We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent "bystander-activated" (CD8(+)CD44high) T cells dis
Externí odkaz:
https://doaj.org/article/8cc561b24e474b77877ada18789ecaf1
Autor:
Xin Chen, Yuan Yang, Qiong Zhou, Jonathan M Weiss, Olamae Zack Howard, John M McPherson, Lalage M Wakefield, Joost J Oppenheim
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85398 (2014)
TGFβ is reportedly responsible for accumulation of CD4(+)Foxp3(+) regulatory T cells (Tregs) in tumor. Thus, we treated mouse 4T1 mammary carcinoma with 1D11, a neutralizing anti-TGFβ (1,2,3) antibody. The treatment delayed tumor growth, but unexpe
Externí odkaz:
https://doaj.org/article/4c41092926b04e128f37a40f65afa400
Autor:
Tim Chan, Timothy C Back, Jeffrey J Subleski, Jonathan M Weiss, John R Ortaldo, Robert H Wiltrout
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33303 (2012)
The liver is an immunologically unique organ containing tolerogenic dendritic cells (DC) that maintain an immunosuppressive microenvironment. Although systemic IL-12 administration can improve responses to tumors, the effects of IL-12-based treatment
Externí odkaz:
https://doaj.org/article/e623811ed0f747109f1da1c1be3d9aa9
Autor:
Erika M. Palmieri, Ronald Holewinski, Christopher L. McGinity, Ciro L. Pierri, Nunziata Maio, Jonathan M. Weiss, Vincenzo Tragni, Katrina M. Miranda, Tracey A. Rouault, Thorkell Andresson, David A. Wink, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that NO targets the PDH complex by usi
Externí odkaz:
https://doaj.org/article/c6b5815c95e344bdaaa97f1c13a3f7f7
Autor:
Caio C. B. Bomfim, Logan Fisher, Eduardo P. Amaral, Lara Mittereder, Katelyn McCann, André A. S. Correa, Sivaranjani Namasivayam, Muthulekha Swamydas, Mahtab Moayeri, Jonathan M. Weiss, Raj Chari, Daniel W. McVicar, Diego L. Costa, Maria R. D’Império Lima, Alan Sher
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in Mycob
Externí odkaz:
https://doaj.org/article/829c533eabff4b7a98e063262dae07c5
Autor:
Li Yang, John C. Morris, Giorgio Trinchieri, Jonathan M. Weiss, Chi-Ping Day, Hannah H. Yan, Zhaoyang Li, Bhagelu R. Achyut, Sudheer Kumar Gara, Yanli Pang
Supplementary Figure 7 - PDF file 111K, Characterization of myeloid cells in lung, tumor, spleen, and lymph nodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157863a5d3e51e1a0b10d029b0215904
https://doi.org/10.1158/2159-8290.22530048.v1
https://doi.org/10.1158/2159-8290.22530048.v1
Autor:
Li Yang, John C. Morris, Giorgio Trinchieri, Jonathan M. Weiss, Chi-Ping Day, Hannah H. Yan, Zhaoyang Li, Bhagelu R. Achyut, Sudheer Kumar Gara, Yanli Pang
Supplementary Figure 1 - PDF file 183K, Overproduction of immature myeloid cells in both tumor bearing mice and cancer patients, flow cytometry analysis and sorting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0524093d089c7703d05db13c8f850976
https://doi.org/10.1158/2159-8290.22530069.v1
https://doi.org/10.1158/2159-8290.22530069.v1
Autor:
Li Yang, John C. Morris, Giorgio Trinchieri, Jonathan M. Weiss, Chi-Ping Day, Hannah H. Yan, Zhaoyang Li, Bhagelu R. Achyut, Sudheer Kumar Gara, Yanli Pang
Supplementary Figure 4 - PDF file 129K, Validation of over expression of TGFbeta1, IL-4, IL10, as well as Arginase1 and iNOS in Tgfbr2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5dc9610042998d1e5ee4982a5ab31b
https://doi.org/10.1158/2159-8290.22530057.v1
https://doi.org/10.1158/2159-8290.22530057.v1
Autor:
Li Yang, John C. Morris, Giorgio Trinchieri, Jonathan M. Weiss, Chi-Ping Day, Hannah H. Yan, Zhaoyang Li, Bhagelu R. Achyut, Sudheer Kumar Gara, Yanli Pang
Supplementary Figure 3 - PDF file 76K, IFN-gamma production by T cells and its effect on tumor growth in Tgfbr2MyeKOand Tgfbr2flox/flox control mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bc7e1d18f58cee6e82a17c40f4f58f
https://doi.org/10.1158/2159-8290.22530060
https://doi.org/10.1158/2159-8290.22530060
Autor:
Li Yang, John C. Morris, Giorgio Trinchieri, Jonathan M. Weiss, Chi-Ping Day, Hannah H. Yan, Zhaoyang Li, Bhagelu R. Achyut, Sudheer Kumar Gara, Yanli Pang
Supplementary Figure 8 - PDF file 84K, Immune cell profiling and IFN-gamma production in CD8 T cells in tumor tissues between Tgfbr2flox/flox and Tgfbr2MyeKO mice bearing 4T1 tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf8418c70833e2954d9a7c94219009a
https://doi.org/10.1158/2159-8290.22530045.v1
https://doi.org/10.1158/2159-8290.22530045.v1