Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Jonathan M Weiss"'
Autor:
Arta M Monjazeb, Julia K Tietze, Steven K Grossenbacher, Hui-Hua Hsiao, Anthony E Zamora, Annie Mirsoian, Brent Koehn, Bruce R Blazar, Jonathan M Weiss, Robert H Wiltrout, Gail D Sckisel, William J Murphy
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e102709 (2014)
We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent "bystander-activated" (CD8(+)CD44high) T cells dis
Externí odkaz:
https://doaj.org/article/8cc561b24e474b77877ada18789ecaf1
Autor:
Xin Chen, Yuan Yang, Qiong Zhou, Jonathan M Weiss, Olamae Zack Howard, John M McPherson, Lalage M Wakefield, Joost J Oppenheim
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85398 (2014)
TGFβ is reportedly responsible for accumulation of CD4(+)Foxp3(+) regulatory T cells (Tregs) in tumor. Thus, we treated mouse 4T1 mammary carcinoma with 1D11, a neutralizing anti-TGFβ (1,2,3) antibody. The treatment delayed tumor growth, but unexpe
Externí odkaz:
https://doaj.org/article/4c41092926b04e128f37a40f65afa400
Autor:
Tim Chan, Timothy C Back, Jeffrey J Subleski, Jonathan M Weiss, John R Ortaldo, Robert H Wiltrout
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33303 (2012)
The liver is an immunologically unique organ containing tolerogenic dendritic cells (DC) that maintain an immunosuppressive microenvironment. Although systemic IL-12 administration can improve responses to tumors, the effects of IL-12-based treatment
Externí odkaz:
https://doaj.org/article/e623811ed0f747109f1da1c1be3d9aa9
Autor:
Erika M. Palmieri, Ronald Holewinski, Christopher L. McGinity, Ciro L. Pierri, Nunziata Maio, Jonathan M. Weiss, Vincenzo Tragni, Katrina M. Miranda, Tracey A. Rouault, Thorkell Andresson, David A. Wink, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate dehydrogenase (PDH) activity. Here, we provide evidence that NO targets the PDH complex by usi
Externí odkaz:
https://doaj.org/article/c6b5815c95e344bdaaa97f1c13a3f7f7
Autor:
Caio C. B. Bomfim, Logan Fisher, Eduardo P. Amaral, Lara Mittereder, Katelyn McCann, André A. S. Correa, Sivaranjani Namasivayam, Muthulekha Swamydas, Mahtab Moayeri, Jonathan M. Weiss, Raj Chari, Daniel W. McVicar, Diego L. Costa, Maria R. D’Império Lima, Alan Sher
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Irg1 is an enzyme that generates itaconate, a metabolite that plays a key role in the regulation of inflammatory responses. Previous studies have implicated Irg1 as an important mediator in preventing excessive inflammation and tissue damage in Mycob
Externí odkaz:
https://doaj.org/article/829c533eabff4b7a98e063262dae07c5
Autor:
Jill W. Ford, Marieli Gonzalez-Cotto, Alexander W. MacFarlane, Suraj Peri, O. M. Zack Howard, Jeffrey J. Subleski, Karen J. Ruth, Mohammed Haseebuddin, Tahseen Al-Saleem, Youfeng Yang, Pat Rayman, Brian Rini, W. Marston Linehan, James Finke, Jonathan M. Weiss, Kerry S. Campbell, Daniel W. McVicar
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) contribute to cancer-related inflammation and tumor progression. While several myeloid molecules have been ascribed a regulatory function in these processes, the triggerin
Externí odkaz:
https://doaj.org/article/b29a1d769f3c4074858d8da7e828b13c
Autor:
Wei Chen, Melanie S. Nyuydzefe, Jonathan M. Weiss, Jingya Zhang, Samuel D. Waksal, Alexandra Zanin-Zhorov
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Rho-associated coiled-coil kinase (ROCK)2 targeting down-regulates autoimmune responses in animal models and patients, however the underlying molecular mechanism is still an enigma. We report that ROCK2 binds phosphorylated-STAT3 and its kin
Externí odkaz:
https://doaj.org/article/161f3b2af832421d851906abac38085c
Autor:
Christopher M. Rice, Luke C. Davies, Jeff J. Subleski, Nunziata Maio, Marieli Gonzalez-Cotto, Caroline Andrews, Nimit L. Patel, Erika M. Palmieri, Jonathan M. Weiss, Jung-Min Lee, Christina M. Annunziata, Tracey A. Rouault, Scott K. Durum, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tum
Externí odkaz:
https://doaj.org/article/21ee446ffa5a4d17bace3aa38b5d4bbd
Autor:
Li Yang, John C. Morris, Giorgio Trinchieri, Jonathan M. Weiss, Chi-Ping Day, Hannah H. Yan, Zhaoyang Li, Bhagelu R. Achyut, Sudheer Kumar Gara, Yanli Pang
Supplementary Figure 7 - PDF file 111K, Characterization of myeloid cells in lung, tumor, spleen, and lymph nodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157863a5d3e51e1a0b10d029b0215904
https://doi.org/10.1158/2159-8290.22530048.v1
https://doi.org/10.1158/2159-8290.22530048.v1
Autor:
Li Yang, John C. Morris, Giorgio Trinchieri, Jonathan M. Weiss, Chi-Ping Day, Hannah H. Yan, Zhaoyang Li, Bhagelu R. Achyut, Sudheer Kumar Gara, Yanli Pang
Supplementary Figure 1 - PDF file 183K, Overproduction of immature myeloid cells in both tumor bearing mice and cancer patients, flow cytometry analysis and sorting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0524093d089c7703d05db13c8f850976
https://doi.org/10.1158/2159-8290.22530069.v1
https://doi.org/10.1158/2159-8290.22530069.v1