Zobrazeno 1 - 10
of 508
pro vyhledávání: '"Jonathan M Schott"'
Autor:
Sarah-Naomi James, Carole Sudre, Nick C Fox, Marcus Richards, Alun Hughes, Josephine Barnes, Jonathan M Schott
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100262- (2024)
Introduction: Data drawn from the 1946 British birth cohort is opportunistically placed to address how midlife cardiac and vascular structure is linked with white matter brain health later in life, given that participants are born in the same week; h
Externí odkaz:
https://doaj.org/article/db444a48760f4e4183745a0cf24f8f18
Publikováno v:
BMJ Open, Vol 13, Iss 11 (2023)
Objective To investigate the accumulation of adversities (duration of exposure to any, economic, psychosocial) across the lifecourse (birth to 63 years) on cognitive function in older age, and the mediating role of mental health.Design National birth
Externí odkaz:
https://doaj.org/article/eea7475e7b1a4b6998f894b107c9aa41
Autor:
Ariane Bollack, Pawel J Markiewicz, Alle Meije Wink, Lloyd Prosser, Johan Lilja, Pierrick Bourgeat, Jonathan M Schott, William Coath, Lyduine E Collij, Hugh G Pemberton, Gill Farrar, Frederik Barkhof, David M Cash
Publikováno v:
NeuroImage, Vol 280, Iss , Pp 120313- (2023)
Purpose: Positron emission tomography (PET) provides in vivo quantification of amyloid-β (Aβ) pathology. Established methods for assessing Aβ burden can be affected by physiological and technical factors. Novel, data-driven metrics have been devel
Externí odkaz:
https://doaj.org/article/31a4b313a057412299854b162b868a65
Autor:
Mohammed Janahi, Leon Aksman, Jonathan M Schott, Younes Mokrab, Andre Altmann, On behalf of for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
eLife, Vol 11 (2022)
Nomograms are important clinical tools applied widely in both developing and aging populations. They are generally constructed as normative models identifying cases as outliers to a distribution of healthy controls. Currently used normative models do
Externí odkaz:
https://doaj.org/article/589d17da14f54668897eaa2214194e00
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-3 (2021)
Abstract On 7 June, the FDA approved aducanumab, the first new drug for Alzheimer’s disease in almost 20 years—and notably, the first drug with a putative disease‐modifying mechanism for the treatment of this devastating disorder, namely the re
Externí odkaz:
https://doaj.org/article/b58865ed2caa4598874cf2c4fbbe5fbf
Autor:
Ashvini Keshavan, Henrietta Wellington, Zhongbo Chen, Ayesha Khatun, Miles Chapman, Melanie Hart, David M. Cash, William Coath, Thomas D. Parker, Sarah M. Buchanan, Sarah E. Keuss, Matthew J. Harris, Heidi Murray‐Smith, Amanda Heslegrave, Nick C. Fox, Henrik Zetterberg, Jonathan M Schott
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract INTRODUCTION We assessed the concordance of cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau measured on the fully automated Lumipulse platform with pre‐symptomatic Alzheimer's disease (AD) pathology on amyloid positron emission tomogr
Externí odkaz:
https://doaj.org/article/6d192a34b4fb4435b96b930df6feef2f
Autor:
Alexandra L Young, Razvan V Marinescu, Neil P Oxtoby, Martina Bocchetta, Keir Yong, Nicholas C Firth, David M Cash, David L Thomas, Katrina M Dick, Jorge Cardoso, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Jason D Warren, Sebastian Crutch, Nick C Fox, Sebastien Ourselin, Jonathan M Schott, Jonathan D Rohrer, Daniel C Alexander, The Genetic FTD Initiative (GENFI), The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal
Externí odkaz:
https://doaj.org/article/edb6d5c8fa064af8b4704e322938446c
Autor:
Sara Garbarino, Marco Lorenzi, Neil P Oxtoby, Elisabeth J Vinke, Razvan V Marinescu, Arman Eshaghi, M Arfan Ikram, Wiro J Niessen, Olga Ciccarelli, Frederik Barkhof, Jonathan M Schott, Meike W Vernooij, Daniel C Alexander, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
eLife, Vol 8 (2019)
The spatial distribution of atrophy in neurodegenerative diseases suggests that brain connectivity mediates disease propagation. Different descriptors of the connectivity graph potentially relate to different underlying mechanisms of propagation. Pre
Externí odkaz:
https://doaj.org/article/59ad7488523a4adcbc229c1e872cf623
Autor:
Thomas D Parker, David M Cash, Christopher A S Lane, Kirsty Lu, Ian B Malone, Jennifer M Nicholas, Sarah-Naomi James, Ashvini Keshavan, Heidi Murray-Smith, Andrew Wong, Sarah M Buchanan, Sarah E Keuss, Carole H Sudre, Marc Modat, David L Thomas, Sebastian J Crutch, Marcus Richards, Nick C Fox, Jonathan M Schott
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224030 (2019)
BackgroundThe human hippocampus comprises a number of interconnected histologically and functionally distinct subfields, which may be differentially influenced by cerebral pathology. Automated techniques are now available that estimate hippocampal su
Externí odkaz:
https://doaj.org/article/5aaf601528a24d96a94d9af0d24ba940
Autor:
K Abigail Andrews, Marc Modat, Kate E Macdonald, Tom Yeatman, M Jorge Cardoso, Kelvin K Leung, Josephine Barnes, Victor L Villemagne, Christopher C Rowe, Nick C Fox, Sebastien Ourselin, Jonathan M Schott, Australian Imaging Biomarkers, Lifestyle Flagship Study of Ageing
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58816 (2013)
There is considerable interest in designing therapeutic studies of individuals at risk of Alzheimer disease (AD) to prevent the onset of symptoms. Cortical β-amyloid plaques, the first stage of AD pathology, can be detected in vivo using positron em
Externí odkaz:
https://doaj.org/article/01e373ae4c5e44d884fcdf0f97c3aaa4