Prognostic heterogeneity and clonal dynamics within distinct subgroups of myelodysplastic syndrome and acute myeloid leukemia with TP53 disruptions

Autor: Shyam A. Patel, Jan Cerny, William K. Gerber, Muthalagu Ramanathan, Asiri Ediriwickrema, Benjamin Tanenbaum, Lloyd Hutchinson, Xiuling Meng, Julie Flahive, Bruce Barton, Andrew J. Gillis‐Smith, Sakiko Suzuki, Salwa Khedr, William Selove, Anne W. Higgins, Patricia M. Miron, Karl Simin, Bruce Woda, Jonathan M. Gerber

Publikováno v: eJHaem, Vol 4, Iss 4, Pp 1059-1070 (2023)

Abstract TP53 aberrations constitute the highest risk subset of myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML). The International Consensus Classification questions the blast threshold between MDS and AML. In this study, we assess t

Externí odkaz: https://doaj.org/article/70cf2e830d364cbbb01832a39b543f0d

COVID-19 convalescent plasma therapy decreases inflammatory cytokines: a randomized controlled trial

Autor: Feben Habtehyimer, Xianming Zhu, Andrew D. Redd, Kelly A. Gebo, Alison G. Abraham, Eshan U. Patel, Oliver Laeyendecker, Thomas J. Gniadek, Reinaldo E. Fernandez, Owen R. Baker, Malathi Ram, Edward R. Cachay, Judith S. Currier, Yuriko Fukuta, Jonathan M. Gerber, Sonya L. Heath, Barry Meisenberg, Moises A. Huaman, Adam C. Levine, Aarthi Shenoy, Shweta Anjan, Janis E. Blair, Daniel Cruser, Donald N. Forthal, Laura L. Hammitt, Seble Kassaye, Giselle S. Mosnaim, Bela Patel, James H. Paxton, Jay S. Raval, Catherine G. Sutcliffe, Matthew Abinante, Kevin S. Oei, Valerie Cluzet, Marie Elena Cordisco, Benjamin Greenblatt, William Rausch, David Shade, Amy L. Gawad, Sabra L. Klein, Andrew Pekosz, Shmuel Shoham, Arturo Casadevall, Evan M. Bloch, Daniel Hanley, Aaron A. R. Tobian, David J. Sullivan

Publikováno v: Microbiology Spectrum, Vol 12, Iss 1 (2024)

ABSTRACT Early COVID-19 convalescent plasma (CCP) transfusion to outpatients with COVID-19 decreases progression to hospitalization, but the mechanism of how CCP reduces severity is unknown. Among 882 COVID-19 participants transfused with CCP or cont

Externí odkaz: https://doaj.org/article/b40c8f00b74440fc8c05d4206e476f46

Antibody Correlates of Protection for COVID-19 Convalescent Plasma Associated with Reduced Outpatient Hospitalizations

Autor: Han-Sol Park, Caelan Barranta, Anna Yin, John S. Lee, Christopher A. Caputo, Maggie Li, Steve Yoon, Ioannis Sitaras, Anne Jedlicka, Yolanda Eby, Malathi Ram, Reinaldo E. Fernandez, Owen R. Baker, Aarthi G. Shenoy, Giselle S. Mosnaim, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C. Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. McBee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Bryan Lau, Stephan Ehrhardt, Sheriza N. Baksh, Janna R. Shapiro, Jiangda Ou, Thomas J. Gniadek, Patrizio Caturegli, Jinke Wu, Nelson Ndahiro, Michael J. Betenbaugh, Alyssa Ziman, Daniel F. Hanley, Arturo Casadevall, Shmuel Shoham, Evan M. Bloch, Kelly A. Gebo, Aaron A.R. Tobian, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, David J. Sullivan

Publikováno v: medRxiv

SARS-CoV-2 antibody levels associated with reduced hospitalization risk remain undefined. Our outpatient COVID-19 convalescent plasma (CCP), placebo-controlled trial observed SARS-CoV-2 antibody levels decreasing 22-fold from matched donor units into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124d32fa90320c1ef7c7c5ee968c932a
https://europepmc.org/articles/PMC10153328/

Natural History of Patients with Clonal Hematopoiesis Seen in Hematology Clinics

Autor: Shyam A Patel, William K Gerber, Lloyd Hutchinson, Shrinkhala Khanna, Jan Cerny, Muthalagu Ramanathan, Andrew Gillis-Smith, Sakiko Suzuki, Gregory A. Abel, Salwa Khedr, William Selove, Bruce Woda, Rena Zheng, Patricia Minehart Miron, Anne Higgins, Jonathan M Gerber

Publikováno v: Blood. 140:5756-5758

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99e4a0cf62d6905c5b85e5db22dd6bce
https://doi.org/10.1182/blood-2022-168473

Clinico-genomic profiling and clonal dynamic modeling of TP53-aberrant myelodysplastic syndrome and acute myeloid leukemia

Autor: Lloyd Hutchinson, Muthalagu Ramanathan, Patricia M. Miron, Anne W. Higgins, Asiri Ediriwickrema, Jonathan M. Gerber, Jan Cerny, Maxwell R Lloyd, Qiming Shi, Karl Simin, Shyam A. Patel

Publikováno v: Leukemia & Lymphoma. 62:3348-3360

TP53-aberrant myelodysplastic syndrome and acute myeloid leukemia have dismal outcomes. Here, we define the clinico-genomic landscape of TP53 disruptions in 40 patients and employ clonal dynamic modeling to map the mutational hierarchy against clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70c80cdb48922d7178c5809a16e42898
https://doi.org/10.1080/10428194.2021.1957869