Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jonathan M Geisinger"'
Autor:
Chunli Zhao, Alfonso P Farruggio, Christopher R R Bjornson, Christopher L Chavez, Jonathan M Geisinger, Tawny L Neal, Marisa Karow, Michele P Calos
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e96279 (2014)
A cell therapy strategy utilizing genetically-corrected induced pluripotent stem cells (iPSC) may be an attractive approach for genetic disorders such as muscular dystrophies. Methods for genetic engineering of iPSC that emphasize precision and minim
Externí odkaz:
https://doaj.org/article/1e626ec91aca44caa7954e946e2d2f9a
Autor:
Qin Li, Michael J. Gloudemans, Jonathan M. Geisinger, Boming Fan, François Aguet, Tao Sun, Gokul Ramaswami, Yang I. Li, Jin-Biao Ma, Jonathan K. Pritchard, Stephen B. Montgomery, Jin Billy Li
Publikováno v:
Nature
A major challenge in human genetics is to identify the molecular mechanisms of trait-associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) mapping of genetic variants with intermediate molecular phenotypes such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2133daa32404237ba4de0cbbbe42bfa
https://doi.org/10.1038/s41586-022-05052-x
https://doi.org/10.1038/s41586-022-05052-x
Autor:
Tao Sun, Qin Li, Jonathan M. Geisinger, Shi-Bin Hu, Boming Fan, Shichen Su, Waitang Tsui, Hongchao Guo, Jinbiao Ma, Jin Billy Li
The innate immune system detects viral infection via pattern recognition receptors and induces defense reactions such as production of type I interferon1. One such receptor, MDA5, is activated upon the recognition of double-stranded RNAs (dsRNAs) tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6143fee41b8976551d3f9702b1e83c65
https://doi.org/10.1101/2022.08.29.505707
https://doi.org/10.1101/2022.08.29.505707
Autor:
Qin, Li, Michael J, Gloudemans, Jonathan M, Geisinger, Boming, Fan, François, Aguet, Tao, Sun, Gokul, Ramaswami, Yang I, Li, Jin-Biao, Ma, Jonathan K, Pritchard, Stephen B, Montgomery, Jin Billy, Li
Publikováno v:
Nature. 608(7923)
A major challenge in human genetics is to identify the molecular mechanisms of trait-associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) mapping of genetic variants with intermediate molecular phenotypes such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::850205050eaafbfd40364b8ea1116b7c
https://pubmed.ncbi.nlm.nih.gov/35922489
https://pubmed.ncbi.nlm.nih.gov/35922489
Autor:
Jonathan M. Geisinger, Tim Stearns
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615379
CRISPR/Cas9 system is a powerful technique for genome editing and engineering but obtaining a sizeable population of edited cells can be challenging for some cell types. CRISPR/Cas9-induced cell cycle arrest is a possible cause of this barrier to eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6316bb6a498d7839fd07d534548c99aa
https://doi.org/10.1007/978-1-0716-1538-6_14
https://doi.org/10.1007/978-1-0716-1538-6_14
Publikováno v:
Bio Protoc
The incorporation of the CRISPR/Cas9 bacterial immune system into the genetic engineering toolbox has led to the development of several new methods for genome manipulation ( Auer et al., 2014 ; Byrne et al., 2015 ). We took advantage of the ability o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6057d0cf5799b206360ab7721b693359
https://doi.org/10.21769/bioprotoc.2163
https://doi.org/10.21769/bioprotoc.2163
Autor:
Christopher L. Chavez, Joseph C. Wu, Jonathan M. Geisinger, Alfonso P. Farruggio, Marisa Karow, Yanru Chen-Tsai, Michele P. Calos, Feng Lan, W. Edward Jung, Annahita Keravala
Publikováno v:
Stem Cells. 29:1696-1704
Induced pluripotent stem cells (iPSCs) have revolutionized the stem cell field. iPSCs are most often produced by using retroviruses. However, the resulting cells may be ill-suited for clinical applications. Many alternative strategies to make iPSCs h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8da216dea9ba10c1311f9b60b5f92fb9
https://doi.org/10.1002/stem.730
https://doi.org/10.1002/stem.730
Autor:
Soha Yazbek, Joseph H. Nadeau, Colleen M. Croniger, Jonathan M. Geisinger, Gabriel E. Zentner, Sabrina H. Spiezio, David A. Buchner, Lindsay C. Burrage, Chang-Wen Hsieh, Peter C. Scacheri
Publikováno v:
Genome Research. 21:1065-1073
Although central to many studies of phenotypic variation and disease susceptibility, characterizing the genetic architecture of complex traits has been unexpectedly difficult. For example, most of the susceptibility genes that contribute to highly he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0220f35271b21f6b8a515d0864a703bc
https://doi.org/10.1101/gr.120741.111
https://doi.org/10.1101/gr.120741.111
Publikováno v:
Nucleic Acids Research
The CRISPR/Cas9 system facilitates precise DNA modifications by generating RNA-guided blunt-ended double-strand breaks. We demonstrate that guide RNA pairs generate deletions that are repaired with a high level of precision by non-homologous end-join
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2797b0af27908778fded7054a48b07ee
https://pubmed.ncbi.nlm.nih.gov/26762978
https://pubmed.ncbi.nlm.nih.gov/26762978
The ability to precisely modify the genome in a site-specific manner is extremely useful. The CRISPR/Cas9 system facilitates precise modifications by generating RNA-guided double-strand breaks. We demonstrate that guide RNA pairs generate deletions t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3f900c8911fc956e0ee2f27d5d9578
https://doi.org/10.1101/019570
https://doi.org/10.1101/019570