Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jonathan M, Goeldner"'
Autor:
Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kückelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiss, Daniel Delev, Julius Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich G. Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Jürgen Beck, Henrike Salié, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The tumour microenvironment counteracts immune therapy in Glioblastomas. Authors show here, using spatially resolved and single cell transcriptomics, that dysfunctional T cells are induced by a myeloid cell subset via Interleukin-10 signalling, and i
Externí odkaz:
https://doaj.org/article/c8ede93aa6744a97b9b18e93349c871a
Autor:
Julian P. Maier, Vidhya M. Ravi, Jan Kueckelhaus, Simon P. Behringer, Niklas Garrelfs, Paulina Will, Na Sun, Jasmin von Ehr, Jonathan M. Goeldner, Dietmar Pfeifer, Marie Follo, Luciana Hannibal, Axel Karl Walch, Ulrich G. Hofmann, Jürgen Beck, Dieter Henrik Heiland, Oliver Schnell, Kevin Joseph
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract Glioblastoma (GBM), the most malignant tumor of the central nervous system, is marked by its dynamic response to microenvironmental niches. In particular, this cellular plasticity contributes to the development of an immediate resistance dur
Externí odkaz:
https://doaj.org/article/b89ed836d7234b6e8298f323cfead154
Autor:
Simon P Behringer, Vidhya M Ravi, Oliver Schnell, Jasim Kada Benotmane, Henrike Salié, Marie Follo, Daniel Delev, Marius Schwabenland, Ulrich G. Hofmann, Melanie Boerries, Jonathan M Goeldner, Mohammed Khiat, Christian Fung, Manching Ku, Axel Walch, Jürgen Beck, Dieter Henrik Heiland, Ugne Kuliesiute, Florian Scherer, Ulrich Schüller, Paulina Will, Lea Vollmer, Na Sun, Pamela Franco, Roman Sankowski, Jasmin von Ehr, Kevin Joseph, Marco Prinz, Katrin Lamszus, Franz Ricklefs, Junyi Zhang, Jan Kueckelhaus, Saskia Killmer, Nicolas Neidert, Bertram Bengsch
Publikováno v:
Cancer cell, Cambridge, MA : Cell Press, 2022, vol. 40, iss. 6, p. 639-655, e1-e13
Cancer Cell 40, 639-655.e13 (2022)
Cancer Cell 40, 639-655.e13 (2022)
Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of the dynamic reorganization within the spatial context of these tumors remains elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e8ee4dd63c97972bea35b3546493e
https://repository.vu.lt/VU:ELABAPDB139646810&prefLang=en_US
https://repository.vu.lt/VU:ELABAPDB139646810&prefLang=en_US
Publikováno v:
Molecular Neurobiology. 56:6046-6055
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with a high recurrence rate and a median survival of about 16 months even with multimodal therapy. Novel experimental strategies against malignant gliomas include cyclooxygenase (COX) i
Autor:
Vidhya M. Ravi, Paulina Will, Jan Kueckelhaus, Na Sun, Kevin Joseph, Henrike Salié, Jasmin von Ehr, Lea Vollmer, Jasim K. Benotmane, Nicolas Neidert, Marie Follo, Florian Scherer, Jonathan M Goeldner, Simon P. Behringer, Pamela Franco, Ulrich G. Hofmann, Christian Fung, Jürgen Beck, Roman Sankowski, Marco Prinz, Saskia Killmer, Bertram Bengsch, Axel Karl Walch, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland
Glioblastomas are highly malignant tumors of the central nervous system. Evidence suggests that these tumors display large intra- and inter-patient heterogeneity hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54c363038a378ba4957da7d5adc0078b
https://doi.org/10.1101/2021.02.16.431475
https://doi.org/10.1101/2021.02.16.431475
Autor:
Florian Scherer, Jonathan M Goeldner, Dieter Henrik Heiland, Julius M Kernbach, Tobias Weiss, Marco Prinz, Kevin Joseph, Pamela Franco, Roman Sankowski, Jan Kückelhaus, Christine Dierks, Maria Stella Carro, Julian P Maier, Nicolas Neidert, Melanie Boerries, Marie Follo, Ulrich G. Hofmann, Simon P Behringer, Paulina Will, Nils Schallner, Vidhya M Ravi, Daniel Delev, Christian Fung, Jürgen Beck, Lea Vollmer, Oliver Schnell
Despite recent advances in cancer immunotherapy, its efficacy in Glioblastoma (GBM) is limited due to poor understanding of molecular states and cellular plasticity of immune cells within the tumor microenvironment. Here, we combined spatial and sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb2383ea71d810fc6a5f797e3076c1e
https://doi.org/10.21203/rs.3.rs-244157/v1
https://doi.org/10.21203/rs.3.rs-244157/v1
Autor:
Roman Sankowski, Saskia Killmer, Kevin Joseph, Henrike Salié, Jonathan M Goeldner, Vidhya M Ravi, Marie Follo, Nicolas Neidert, Na Sun, Ulrich G. Hofmann, Florian Scherer, Simon P Behringer, Jasim Kada Benotmane, Jan Kekelhaus, Daniel Delev, Oliver Schnell, Lea Vollmer, Christian Fung, Jürgen Beck, Dieter Henrik Heiland, Paulina Will, Bertram Bengsch, Marco Prinz, Pamela Franco, Jasmin von Ehr, Axel Walch
Glioblastomas are highly malignant tumors of the central nervous system. Evidence suggests that these tumors display large intra- and inter-patient heterogeneity hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4874e0d1d05588b27fb7dddf6d13147d
https://doi.org/10.21203/rs.3.rs-244902/v1
https://doi.org/10.21203/rs.3.rs-244902/v1
Autor:
Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kückelhaus, Lea Vollmer, Jonathan M Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiss, Daniel Delev, Julius Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich G. Hofmann, Christian Fung, Jürgen Beck, Roman Sankowski, Marco Prinz, Oliver Schnell, Dieter Henrik Heiland
SummaryThe diversity of molecular states and cellular plasticity of immune cells in the glioblastoma environment is still poorly understood. Here, we performed scRNA sequencing of the immune compartment and mapped potential cellular interactions lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f1329fb3b8260bca632e06100df341c
https://doi.org/10.1101/2020.06.01.121467
https://doi.org/10.1101/2020.06.01.121467
Autor:
Jessica, Guenzle, Louisa J, Wolf, Nicklas W C, Garrelfs, Jonathan M, Goeldner, Nadja, Osterberg, Cora R, Schindler, Joseph E, Saavedra, Astrid, Weyerbrock
Publikováno v:
Cell Death Discovery
Glioblastoma is associated with poor survival and a high recurrence rate in patients due to inevitable uncontrolled infiltrative tumor growth. The elucidation of the molecular mechanisms may offer opportunities to prevent relapses. In this study we i
Publikováno v:
Neuro-Oncology. 19:iii57-iii57
Objective: Glioblastoma is associated with poor survival and a high recurrence rate in patients due to the inevitable uncontrolled infiltrative tumor growth. The elucidation of the molecular mechanisms may offer opportunities to prevent relapses. In