O-Methyl-N-Nitroisourea as a NCO Surrogate in Cu-Catalyzed Alkane C-H isocyanation. A Masked Isocyanate Strategy

Autor: Yannick LANDAIS, Jonathan Lusseau, Frédéric Robert

The Cu-catalyzed C-H activation of alkanes in the presence of O-methyl-N-nitroisourea affords a facile entry to O-methyl-N-alkylnitroisoureas, shelf stable and benign isocyanate precursors. The latter is then readily converted into carbamates and ure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3e2fd090273cf5bf0c5612db4aaa4f0
https://doi.org/10.26434/chemrxiv-2022-zn2th

An Approach towards the Synthesis of the Spiroimine Fragment of 13-Desmethylspirolide C and Gymnodimine A

Autor: Yannick Landais, Valérie Desvergnes, Stéphane Massip, Jonathan Lusseau, Alexandre Guthertz

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2019, 25 (6), pp.1553-1560. ⟨10.1002/chem.201804972⟩

A general access to the spiroimine skeleton of gymnodimine and spirolides is described, relying on the construction of the cyclohexene fragment using an enantiocontrolled Diels-Alder reaction, the installation of the all-carbon quaternary stereocente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8475a37d3f51c24de731fced2edaeca1
https://doi.org/10.1002/chem.201804972

Copper-catalyzed oxidative benzylic C(sp

Autor: Shuai, Liu, Raphaël, Achou, Coline, Boulanger, Govind, Pawar, Nivesh, Kumar, Jonathan, Lusseau, Frédéric, Robert, Yannick, Landais

Publikováno v: Chemical communications (Cambridge, England). 56(85)

A new efficient strategy to access benzylic carbamates through C-H activation is reported. The use of a catalytic amount of a Cu(i)/diimine ligand in combination with NFSI ((PhSO2)2NF) or F-TEDA-PF6 as oxidants and H2NCO2R as an amine source directly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89ea385ffbf9e97f2270eae94828c7af
https://pubmed.ncbi.nlm.nih.gov/32996936

Copper-catalyzed oxidative benzylic C(sp 3 )–H amination: direct synthesis of benzylic carbamates

Autor: Coline Boulanger, Jonathan Lusseau, Nivesh Kumar, Yannick Landais, Frédéric Robert, Shuai Liu, Govind Goroba Pawar, Raphaël Achou

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2020, 56 (85), pp.13013-13016. ⟨10.1039/d0cc05226d⟩

International audience; A new efficient strategy to access benzylic carbamates through C-H activation is reported. The use of a catalytic amount of Cu(I)/diimine ligand in combination with NFSI ((PhSO2)2NF) or F-TEDA-PF6 as oxidants and H2NCO2R as an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634760a83bf7303bc9cb4b772c7cd641
https://hal.archives-ouvertes.fr/hal-02988418

A Unified Strategy Toward 5-, 6-, and 7-Membered Nitrogen Heterocycles Through Free Radical then Metal-Mediated Functionalization of Ene-carbamates

Autor: Frédéric Robert, Redouane Beniazza, Jonathan Lusseau, Clément Poittevin, Yannick Landais, Stéphane Massip

Publikováno v: Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2017, 359 (18), pp.3217-3225. ⟨10.1002/adsc.201700485⟩
Advanced Synthesis and Catalysis, 2017, 359 (18), pp.3217-3225. ⟨10.1002/adsc.201700485⟩

International audience; Free-radical carbo-alkenylation of N-aryl, N-benzyl, and N-phenethyl-ene-carbamates with a disulfone provides vinylsulfones which may then be functionalized and engaged in Heck-type coupling to furnish highly substituted 5-, 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c991c412d86e91ff3eacef1c5874a59b
https://hal.archives-ouvertes.fr/hal-03104344/file/Manuscript_HAL.pdf