Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jonathan Lowther"'
Autor:
Christopher J. McLean, Jon Marles-Wright, Rafael Custodio, Jonathan Lowther, Amanda J. Kennedy, Jacob Pollock, David J. Clarke, Alan R. Brown, Dominic J. Campopiano
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 137-150 (2017)
Sphingolipids (SLs) are ubiquitous elements in eukaryotic membranes and are also found in some bacterial and viral species. As well as playing an integral structural role, SLs also act as potent signaling molecules involved in numerous cellular pathw
Externí odkaz:
https://doaj.org/article/b88abd542b6b4e52bfb50f3531326388
Autor:
Jonathan Lowther, Mark W Robinson, Sheila M Donnelly, Weibo Xu, Colin M Stack, Jacqueline M Matthews, John P Dalton
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 1, p e369 (2009)
The helminth parasite Fasciola hepatica secretes cathepsin L cysteine proteases to invade its host, migrate through tissues and digest haemoglobin, its main source of amino acids. Here we investigated the importance of pH in regulating the activity a
Externí odkaz:
https://doaj.org/article/50ca6e8f1bc54096ae780fbbc94fd6ae
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa053⟩
Nucleic Acids Research, 2020, ⟨10.1093/nar/gkaa053⟩
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa053⟩
Nucleic Acids Research, 2020, ⟨10.1093/nar/gkaa053⟩
Ubiquitylation of the eukaryotic sliding clamp, PCNA, activates a pathway of DNA damage bypass that facilitates the replication of damaged DNA. In its monoubiquitylated form, PCNA recruits a set of damage-tolerant DNA polymerases for translesion synt
Autor:
Christopher J. McLean, Jon Marles-Wright, Rafael Custodio, Jonathan Lowther, Amanda J. Kennedy, Jacob Pollock, David J. Clarke, Alan R. Brown, Dominic J. Campopiano
Publikováno v:
Mclean, C J, Marles-wright, J, Custodio, R, Lowther, J, Kennedy, A J, Pollock, J, Clarke, D, Brown, A R & Campopiano, D J 2016, ' Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei ', Journal of lipid research, vol. 58, no. 1, pp. 137-150 . https://doi.org/10.1194/jlr.M071258
Journal of Lipid Research, Vol 58, Iss 1, Pp 137-150 (2017)
Journal of Lipid Research, Vol 58, Iss 1, Pp 137-150 (2017)
Sphingolipids (SLs) are ubiquitous elements in eukaryotic membranes and are also found in some bacterial and viral species. As well as playing an integral structural role, SLs also act as potent signalling molecules involved in numerous cellular path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::79f853f54448271ecf8bf7e47b28af3a
https://www.pure.ed.ac.uk/ws/files/30257988/20161026_Campopiano_McLean_et_al_Text_and_Figs_Resubmission.pdf
https://www.pure.ed.ac.uk/ws/files/30257988/20161026_Campopiano_McLean_et_al_Text_and_Figs_Resubmission.pdf
Autor:
Christopher J. McLean, Mitali Sarkar-Tyson, Rafael Custodio, Amanda J. Kennedy, Alan R. Brown, Dominic J. Campopiano, David Clarke, Jonathan Lowther, Andrew E. Scott
Publikováno v:
Custódio, R, Mclean, C J, Scott, A E, Lowther, J, Kennedy, A, Clarke, D J, Campopiano, D J, Sarkar-Tyson, M & Brown, A R 2016, ' Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei ', Molecular Microbiology . https://doi.org/10.1111/mmi.13531
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, plays a critical role in the orchestration of immune responses. S1P levels within the mammalian host are tightly regulated, in part through the activity of S1P lyase (S1PL) which cat
Autor:
Christopher J, McLean, Jon, Marles-Wright, Rafael, Custodio, Jonathan, Lowther, Amanda J, Kennedy, Jacob, Pollock, David J, Clarke, Alan R, Brown, Dominic J, Campopiano
Publikováno v:
Journal of Lipid Research
Sphingolipids (SLs) are ubiquitous elements in eukaryotic membranes and are also found in some bacterial and viral species. As well as playing an integral structural role, SLs also act as potent signaling molecules involved in numerous cellular pathw
Autor:
Jonathan Lowther, Colin M. Stack, Tina S. Skinner-Adams, Artur Mucha, Katharine R. Trenholme, Marcin Drag, Donald L. Gardiner, John P. Dalton, Sheena McGowan, Christopher L. Brown, Paweł Kafarski, James C. Whisstock, Jolanta Grembecka
Publikováno v:
Trends in Biochemical Sciences. 35:53-61
The neutral aminopeptidases M1 alanyl aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) of the human malaria parasite Plasmodium falciparum are targets for the development of novel anti-malarial drugs. Although the functions of these
Autor:
Marine C.C. Raman, Beverley A. Yard, James H. Naismith, Lester G. Carter, Jonathan Lowther, Kenneth A. Johnson, Dominic J. Campopiano
Publikováno v:
Journal of Biological Chemistry. 284:17328-17339
Sphingolipid biosynthesis begins with the condensation of l-serine and palmitoyl-CoA catalyzed by the PLP-dependent enzyme serine palmitoyltransferase (SPT). Mutations in human SPT cause hereditary sensory autonomic neuropathy type 1, a disease chara
Autor:
Donald L. Gardiner, Jonathan Lowther, Mark W. Robinson, Sheila Donnelly, Katharine R. Trenholme, Selma Maric, Colin M. Stack, John P. Dalton, Tina S. Skinner-Adams
Publikováno v:
Biochemistry. 48:5435-5439
The M17 leucine aminopeptidase of the intraerythrocytic stages of the malaria parasite Plasmodium falciparum (PfLAP) plays a role in releasing amino acids from host hemoglobin that are used for parasite protein synthesis, growth, and development. Thi
Autor:
Deborah J. Stenzel, Jonathan Lowther, Mark S. Pearson, Jeffrey J. Gorman, Najju Ranjit, Brett Hamilton, Peter J. Hotez, Bin Zhan, Alex Loukas
Publikováno v:
The Journal of Infectious Diseases
*This article is free to read on the publisher's website* Blood-feeding parasites use mechanistically distinct proteases to digest hemoglobin (Hb), often as multienzyme cooperative cascades. We investigated the roles played by 3 distinct proteases fr