Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jonathan Loi"'
Autor:
Jichao Sun, Jared Carlson-Stevermer, Utpal Das, Minjie Shen, Marion Delenclos, Amanda M. Snead, So Yeon Koo, Lina Wang, Dianhua Qiao, Jonathan Loi, Andrew J. Petersen, Michael Stockton, Anita Bhattacharyya, Mathew V. Jones, Xinyu Zhao, Pamela J. McLean, Andrew A. Sproul, Krishanu Saha, Subhojit Roy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Gene editing strategies are typically designed to correct mutant genes, but most neurodegenerative diseases are sporadic. Here the authors describe a strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregu
Externí odkaz:
https://doaj.org/article/9b7514e64c5f429f8af27f9559663d3c
Publikováno v:
Journal of Cell Biology. 222
The widespread use of fluorescence microscopy has prompted the ongoing development of tools aiming to improve resolution and quantification accuracy for study of biological questions. Current calibration and quantification tools for fluorescence imag
Autor:
Jichao Sun, Utpal Das, Archan Ganguly, Ghislaine Caillol, Lina Wang, Subhojit Roy, John R. Yates, Xuemei Han, Daniel Gitler, Jonathan Loi, Christophe Leterrier
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, 2017, 216 (7), pp.2059-2074. ⟨10.1083/jcb.201604028⟩
Journal of Cell Biology
Journal of Cell Biology, 2017, 216 (7), pp.2059-2074. ⟨10.1083/jcb.201604028⟩
Using proteomics, live microscopy, and superresolution microscopy, Ganguly et al. offer insight into the molecular composition of cytosolic cargo complexes conveyed in slow axonal transport, identifying the heat shock protein Hsc70 as a major regulat
Autor:
Minjie Shen, Dianhua Qiao, Jonathan Loi, Jared Carlson-Stevermer, Pamela J. McLean, So Yeon Koo, Andrew J. Petersen, Mathew V. Jones, Marion Delenclos, Subhojit Roy, Lina Wang, Jichao Sun, Utpal Das, Xinyu Zhao, Amanda M. Snead, Andrew Sproul, Michael E. Stockton, Krishanu Saha, Anita Bhattacharyya
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
CRISPR/Cas9 guided gene-editing is a potential therapeutic tool, however application to neurodegenerative disease models has been limited. Moreover, conventional mutation correction by gene-editing would only be relevant for the small fraction of neu
Autor:
Jared Carlson-Stevermer, Minjie Shen, Andrew J. Petersen, Amanda M. Snead, Andrew Sproul, Anita Bhattacharyya, Mathew V. Jones, Jonathan Loi, Xinyu Zhao, Jichao Sun, Michael E. Stockton, Krishanu Saha, Lina Wang, Marion Delenclos, Subhojit Roy, Pamela J. McLean, Utpal Das
The gradual accumulation of amyloid-β (Aβ) is a neuropathologic hallmark of Alzheimer’s disease (AD); playing a key role in disease progression. Aβ is generated by the sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9bb2cf5af478e33e1ce121f52019acf
Autor:
Utpal Das, Lina Wang, Andrew J. Petersen, Amanda M. Snead, Pamela J. McLean, Jonathan Loi, Jared Carlson-Stevermer, Marion Delenclos, Subhojit Roy, Xinyu Zhao, Minjie Shen, Jichao Sun, Mathew V. Jones, Andrew Sproul, Michael E. Stockton, Krishanu Saha, Anita Bhattacharyya
Publikováno v:
SSRN Electronic Journal.
CRISPR/Cas9 guided gene-editing is emerging as a promising therapeutic tool, however application to neurodegenerative diseases has been limited. Moreover, conventional ‘mutation correction’ by gene-editing would only be relevant for the small fra
Autor:
Kelsey Ladt, Bénédicte Dargent, Jonathan Loi, Lina Wang, Archan Ganguly, Subhojit Roy, Christophe Leterrier, Yong Tang
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2015, 210 (3), pp.401-417. ⟨10.1083/jcb.201506110⟩
Journal of Cell Biology, 2015, 210 (3), pp.401-417. ⟨10.1083/jcb.201506110⟩
The Journal of cell biology, vol 210, iss 3
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2015, 210 (3), pp.401-417. ⟨10.1083/jcb.201506110⟩
Journal of Cell Biology, 2015, 210 (3), pp.401-417. ⟨10.1083/jcb.201506110⟩
The Journal of cell biology, vol 210, iss 3
Low-light live imaging of F-actin–selective probes, quantitative tools, and super-resolution microscopy reveals a dynamic, formin-dependent deep F-actin cytoskeletal network in axons.
Although actin at neuronal growth cones is well-studied, mu
Although actin at neuronal growth cones is well-studied, mu