Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jonathan Lipscomb"'
Autor:
Ivana Massud, Kenji Nishiura, Susan Ruone, Angela Holder, Chuong Dinh, Jonathan Lipscomb, James Mitchell, George M. Khalil, Walid Heneine, J. Gerardo Garcίa-Lerma, Charles W. Dobard
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 384 (2024)
Pre-exposure prophylaxis (PrEP) with a weekly oral regimen of antiretroviral drugs could be a suitable preventative option for individuals who struggle with daily PrEP or prefer not to use long-acting injectables. We assessed in macaques the efficacy
Externí odkaz:
https://doaj.org/article/a522a275318c403b8197fc61f71923cd
Autor:
Anna Maria Geretti, Zoe Fox, Jeffrey A Johnson, Clare Booth, Jonathan Lipscomb, Lieven J Stuyver, Gilda Tachedjian, John Baxter, Giota Touloumi, Clara Lehmann, Andrew Owen, Andrew Phillips, INSIGHT Strategies for Management of Antiretroviral Therapy (SMART) Study Group
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69266 (2013)
Non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant mutants have been shown to emerge after interruption of suppressive NNRTI-based antiretroviral therapy (ART) using routine testing. The aim of this study was to quantify the risk of res
Externí odkaz:
https://doaj.org/article/e99c580f9fbc475fa9fb7646e0ee7b36
Autor:
Jeffrey A Johnson, Jin-Fen Li, Xierong Wei, Jonathan Lipscomb, David Irlbeck, Charles Craig, Amanda Smith, Diane E Bennett, Michael Monsour, Paul Sandstrom, E Randall Lanier, Walid Heneine
Publikováno v:
PLoS Medicine, Vol 5, Iss 7, p e158 (2008)
BACKGROUND: Transmitted HIV-1 drug resistance can compromise initial antiretroviral therapy (ART); therefore, its detection is important for patient management. The absence of drug-associated selection pressure in treatment-naïve persons can cause d
Externí odkaz:
https://doaj.org/article/cf01c8adc7c94e3cb0906f0b55865483
Autor:
J Gerardo García-Lerma, Ron A Otten, Shoukat H Qari, Eddie Jackson, Mian-Er Cong, Silvina Masciotra, Wei Luo, Caryn Kim, Debra R Adams, Michael Monsour, Jonathan Lipscomb, Jeffrey A Johnson, David Delinsky, Raymond F Schinazi, Robert Janssen, Thomas M Folks, Walid Heneine
Publikováno v:
PLoS Medicine, Vol 5, Iss 2, p e28 (2008)
In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pre-exposure prophylaxis (PrEP) with antiretroviral drugs could prove to be an effective intervention strat
Externí odkaz:
https://doaj.org/article/200116450461413e9f478877b491dbf5
Autor:
Jeffrey A Johnson, Jin-Fen Li, Xierong Wei, Jonathan Lipscomb, Diane Bennett, Ashley Brant, Mian-Er Cong, Thomas Spira, Robert W Shafer, Walid Heneine
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e638 (2007)
BACKGROUND: The success of antiretroviral therapy is known to be compromised by drug-resistant HIV-1 at frequencies detectable by conventional bulk sequencing. Currently, there is a need to assess the clinical consequences of low-frequency drug resis
Externí odkaz:
https://doaj.org/article/a7baeb48ea674ab38c7e9668d895506e
Autor:
Janet M. McNicholl, Debra L. Hanson, J. Gerardo García-Lerma, Charles Dobard, Chuong Dinh, Walid Heneine, Tara Henning, Natalia Makarova, John R. Papp, Jonathan Lipscomb, Christi Phillips, Rachael D. Aubert, James Mitchell, Ellen N. Kersh, Andrew Taylor
Publikováno v:
AIDS. 31:745-752
Chlamydia trachomatis and Trichomonas vaginalis, two prevalent sexually transmitted infections, are known to increase HIV risk in women and could potentially diminish preexposure prophylaxis efficacy, particularly for topical interventions that rely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40053d558a7c57784d329222119c2885
https://doi.org/10.1097/qad.0000000000001389
https://doi.org/10.1097/qad.0000000000001389
Autor:
Mara Sterling, William Spreen, J. Gerardo García-Lerma, Angela Holder, Walid Heneine, George Khalil, Natalia Makarova, Jonathan Lipscomb, Charles Dobard, Frank Deyounks, James Mitchell, Kenji Nishiura, Chuong Dinh, David W. Garber
Publikováno v:
The Journal of infectious diseases. 222(3)
We used a novel penile simian-human immunodeficiency virus (SHIV) transmission model to investigate whether long-acting cabotegravir (CAB LA) prevents penile SHIV acquisition in macaques. Twenty-two macaques were exposed to SHIV via the foreskin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c0f29e28586878ca2123bb99b025a2
https://pubmed.ncbi.nlm.nih.gov/32128569
https://pubmed.ncbi.nlm.nih.gov/32128569
Autor:
Darius Babusis, Ryan Johnson, Walid Heneine, Christian Callebaut, Angela Holder, George Khalil, Yeojin Park, Mian-er Cong, Chuong Dinh, James F. Rooney, J. Gerardo García-Lerma, Ivana Massud, Jonathan Lipscomb, Scott McCallister, Kenji Nishiura, Frank Deyounks, Susan Ruone, Yi Pan
Publikováno v:
The Journal of infectious diseases. 220(11)
BackgroundTenofovir alafenamide (TAF)-based regimens are being evaluated for pre-exposure prophylaxis (PrEP). We used a macaque model of repeated exposures to simian human immunodeficiency virus (SHIV) to investigate whether TAF alone or the combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41135b7bfcd6ff628868ac7b5d3ec4cb
https://pubmed.ncbi.nlm.nih.gov/31362305
https://pubmed.ncbi.nlm.nih.gov/31362305
Autor:
William M. Switzer, Jonathan Lipscomb, Silvina Masciotra, S. Michele Owen, Jeffrey A. Johnson, Jin-Fen Li
Publikováno v:
The Journal of Infectious Diseases. 210:1827-1837
Background Drug resistance mutations (DRMs) can serve as distinct, nonpolymorphic markers for evaluating diversity of expressed HIV-1. We screened for DRMs during early-acute viremia and examined the diversity in reverse transcriptase (RT) relative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2e66dbf1a828f7a9a38b8b2b52d4bb
https://doi.org/10.1093/infdis/jiu333
https://doi.org/10.1093/infdis/jiu333
Autor:
Alison Kohlmeier, Jonathan Lipscomb, Jin-fen Li, Ariana Santos Tino, Albert M Anderson, Jeffrey A Johnson
Publikováno v:
The Journal of Immunology. 202:51.15-51.15
Incomplete HIV virologic suppression in the central nervous system (CNS) can cause persisting neurologic disorders even with suppressed plasma viremia. To better understand immune properties that support CNS virus persistence we characterized T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c3213bc62408f69c1169b17806a160
https://doi.org/10.4049/jimmunol.202.supp.51.15
https://doi.org/10.4049/jimmunol.202.supp.51.15