Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan Lasham"'
Autor:
Liina Hannula, Suvi Kuivanen, Jonathan Lasham, Ravi Kant, Lauri Kareinen, Mariia Bogacheva, Tomas Strandin, Tarja Sironen, Jussi Hepojoki, Vivek Sharma, Petri Saviranta, Anja Kipar, Olli Vapalahti, Juha T. Huiskonen, Ilona Rissanen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTIn response to the ongoing COVID-19 pandemic, the quest for coronavirus inhibitors has inspired research on a variety of small proteins beyond conventional antibodies, including robust single-domain antibody fragments, i.e., “nanobodies.”
Externí odkaz:
https://doaj.org/article/cecbf8f257de4f2482e0413c26276bab
Respiratory complex I in mitochondria and bacteria catalyzes the transfer of electrons from NADH to quinone (Q). The free energy available from the reaction is used to pump protons and to establish a membrane proton electrochemical gradient, which dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df193307cfc21239f5de6901e3c1f6ee
http://hdl.handle.net/10138/356023
http://hdl.handle.net/10138/356023
Publikováno v:
Chemical Science.
Respiratory complex I is a redox-driven proton pump contributing to about 40% of total proton motive force required for mitochondrial ATP generation. Recent high-resolution cryo-EM structural data revealed the positions of several water molecules in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfa4639b23faca93cb2e5837418e2fa
https://doi.org/10.1039/d3sc01427d
https://doi.org/10.1039/d3sc01427d
Autor:
Tomoo Shiba, Takahiro Masuya, Daniel Ken Inaoka, Vivek Sharma, Masatoshi Murai, Outi Haapanen, Shinpei Uno, Kyoko Shinzawa-Itoh, Jonathan Lasham, Hideto Miyoshi
Publikováno v:
J Biol Chem
NADH-quinone oxidoreductase (complex I) couples electron transfer from NADH to quinone with proton translocation across the membrane. Quinone reduction is a key step for energy transmission from the site of quinone reduction to the remotely located p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7f4cd6b1302631ad5ca73710102396
https://doi.org/10.1074/jbc.ra119.012347
https://doi.org/10.1074/jbc.ra119.012347
Autor:
Liina Hannula, Suvi Kuivanen, Jonathan Lasham, Ravi Kant, Lauri Kareinen, Mariia Bogacheva, Tomas Strandin, Tarja Sironen, Vivek Sharma, Petri Saviranta, Anja Kipar, Olli Vapalahti, Juha T. Huiskonen, Ilona Rissanen
Publikováno v:
BioRxiv
bioRxiv
bioRxiv
In response to the ongoing SARS-CoV-2 pandemic, the quest for coronavirus inhibitors has inspired research on a variety of small proteins beyond conventional antibodies, including robust single-domain antibody fragments, ‘nanobodies’. Here, we ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937dd6201d28d993d4bb79234a14dec2
Autor:
Volker Zickermann, Janet Vonck, Jonathan Lasham, Vivek Sharma, Hao Xie, Deryck J. Mills, Etienne Galemou Yoga, Amina Djurabekova, Kristian Parey, Outi Haapanen, Werner Kühlbrandt
Publikováno v:
Science Advances
Description
High-resolution structure and molecular simulations unravel the inner workings of a redox-driven proton pump.
Mitochondrial NADH:ubiquinone oxidoreductase (complex I) is a 1-MDa membrane protein complex with a central role in en
High-resolution structure and molecular simulations unravel the inner workings of a redox-driven proton pump.
Mitochondrial NADH:ubiquinone oxidoreductase (complex I) is a 1-MDa membrane protein complex with a central role in en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74168b4fa8f0f5987dd04be488a7dd6
http://europepmc.org/articles/PMC8589321
http://europepmc.org/articles/PMC8589321
Autor:
Patryk Kuleta, Robert Ekiert, Jonathan Lasham, Arkadiusz Borek, Anna Wójcik-Augustyn, Vivek Sharma, Artur Osyczka
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1863:148745
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5076d3c95b9796f60afdd331a526aacc
https://doi.org/10.1016/j.bbabio.2022.148745
https://doi.org/10.1016/j.bbabio.2022.148745
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1863:148648
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4515d7a80e16513a4f435217c20633de
https://doi.org/10.1016/j.bbabio.2022.148648
https://doi.org/10.1016/j.bbabio.2022.148648
Autor:
Patryk Kuleta, Iwona Ekiert, Artur Osyczka, Marcin Sarewicz, Vivek Sharma, Jonathan Lasham, Robert Ekiert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance To perform their specific electron-transfer relay functions, hemes commonly adopt low spin states with fine-tuned redox potentials. Understanding molecular elements controlling these properties is crucial for the description of natural p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e42538b3f050564acf228b5aff769db
http://europepmc.org/articles/PMC8379992
http://europepmc.org/articles/PMC8379992
Autor:
Shinpei Uno, Takahiro Masuya, Oleksii Zdorevskyi, Ryo Ikunishi, Kyoko Shinzawa-Itoh, Jonathan Lasham, Vivek Sharma, Masatoshi Murai, Hideto Miyoshi
Publikováno v:
Journal of Biological Chemistry. 298:102075
The ubiquinone (UQ) reduction step catalyzed by NADH-UQ oxidoreductase (mitochondrial respiratory complex I) is key to triggering proton translocation across the inner mitochondrial membrane. Structural studies have identified a long, narrow, UQ-acce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93180128d70e0447f39ca61cdef6f82d
https://doi.org/10.1016/j.jbc.2022.102075
https://doi.org/10.1016/j.jbc.2022.102075