Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jonathan LaRochelle"'
Autor:
Yong Ge, Changjun Yang, Mojgan Zadeh, Shane M. Sprague, Yang-Ding Lin, Heetanshi Sanjay Jain, Brenden Fitzgerald Determann, II, William H. Roth, Juan Pablo Palavicini, Jonathan Larochelle, Eduardo Candelario-Jalil, Mansour Mohamadzadeh
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109480- (2024)
Summary: Ischemic stroke is the second leading cause of death and disability worldwide, and efforts to prevent stroke, mitigate secondary neurological damage, and promote neurological recovery remain paramount. Recent findings highlight the critical
Externí odkaz:
https://doaj.org/article/582214adb88045e692a188fba6a6f725
Autor:
Jonathan Larochelle, Ryland J. Tishko, Changjun Yang, Yong Ge, Leah T. Phan, Rachel E. Gunraj, Sofia M. Stansbury, Lei Liu, Mansour Mohamadzadeh, Habibeh Khoshbouei, Eduardo Candelario-Jalil
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-22 (2023)
Abstract Background Receptor-interacting protein kinase 2 (RIPK2) is a serine/threonine kinase whose activity propagates inflammatory signaling through its association with pattern recognition receptors (PRRs) and subsequent TAK1, NF-κB, and MAPK pa
Externí odkaz:
https://doaj.org/article/3146fb098a39481daed22a833d93cdcd
Autor:
Lei Liu, Changjun Yang, Bianca P. Lavayen, Ryland J. Tishko, Jonathan Larochelle, Eduardo Candelario-Jalil
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal domain (BET) protein family, plays a crucial role in regulating inflammation and oxidative stress that are tightly related to stroke development and prog
Externí odkaz:
https://doaj.org/article/cf016f1d2590468cbb61fd16eae26ae5
Autor:
Changjun Yang, Bianca P. Lavayen, Lei Liu, Brian D. Sanz, Kelly M. DeMars, Jonathan Larochelle, Marjory Pompilus, Marcelo Febo, Yu-Yo Sun, Yi-Min Kuo, Mansour Mohamadzadeh, Susan A. Farr, Chia-Yi Kuan, Andrew A. Butler, Eduardo Candelario-Jalil
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102197- (2021)
Adropin is a highly-conserved peptide that has been shown to preserve endothelial barrier function. Blood-brain barrier (BBB) disruption is a key pathological event in cerebral ischemia. However, the effects of adropin on ischemic stroke outcomes rem
Externí odkaz:
https://doaj.org/article/d7c0488233404b359c5b732943c3ea34
Autor:
Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J LaMarche, Michael G Acker, Peter K Sorger, Steven P Gygi, Stephen C Blacklow
Publikováno v:
eLife, Vol 10 (2021)
SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. Here, we examine the role of SHP2 in the responses of breast
Externí odkaz:
https://doaj.org/article/653eeb5ad6e5454e9488ec62514b8bc7
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C674-C678
Adropin is a highly conserved secreted peptide encoded by the Energy Homeostasis Associated gene ( Enho). It is expressed in many tissues throughout the body, including the liver and brain, and plays a crucial role in maintaining lipid homeostasis an
Autor:
Changjun Yang, Lei Liu, Bianca P. Lavayen, Jonathan Larochelle, Rachel E. Gunraj, Andrew A. Butler, Eduardo Candelario-Jalil
Publikováno v:
Stroke. 54:234-244
Background: Adropin is a peptide encoded by the energy homeostasis-associated gene ( Enho ) that is highly expressed in the brain. Aging and stroke are associated with reduced adropin levels in the brain and plasma. We showed that treatment with synt
Publikováno v:
Stroke. 53:3238-3242
Poststroke infections are common complications of stroke and are highly associated with poor outcomes for patients. Stroke induces profound immunodepression coupled with alterations to autonomic signaling, which together render the body more suscepti
Autor:
Jonathan Larochelle, Ryland Tishko, Changjun Yang, Lei Liu, Rachel Gunraj, Eduardo Candelario-Jalil
Publikováno v:
Stroke. 54
Background: Stroke is associated with profound immunodepression and aberrations of autonomic signaling which render the body more susceptible to infection from without and from within. Dramatic alterations of sensitive signaling networks within the g
Autor:
Ermira Pazolli, Randy Kipp, Alessandro Boezio, Hakan Gunaydin, Amanda Iskandar, Matthew Zubrowski, Bret Williams, Kelley Shortsleeves, Alexandre Larivee, Tom McLean, Klaus Michelsen, Hongtao Zeng, Jonathan LaRochelle, Joe Manna, Lucian DiPietro, Andre Lescarbeau, Mary Mader, Bindu Bennet, Jeremy Wilbur, Qi Wang, Levi Pierce, Iain Martin, James Watters, Pascal Fortin, Donald Bergstrom
Publikováno v:
Cancer Research. 82:P5-16
Inhibition of CDK4/6 combined with the estrogen receptor (ER) degrader fulvestrant significantly improves progression free survival and overall survival in advanced hormone receptor positive (HR+) breast cancer patients and is now the standard of car