Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jonathan L. Robinson"'
Autor:
Johan Gustafsson, Fariba Roshanzamir, Anders Hagnestål, Sagar M. Patel, Oseeyi I. Daudu, Donald F. Becker, Jonathan L. Robinson, Jens Nielsen
Publikováno v:
The Innovation, Vol 5, Iss 2, Pp 100583- (2024)
The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation, but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchang
Externí odkaz:
https://doaj.org/article/9e6bffeb227247c0a24605903ef2f941
Autor:
Rasool Saghaleyni, Magdalena Malm, Noah Moruzzi, Jan Zrimec, Ronia Razavi, Num Wistbacka, Hannes Thorell, Anton Pintar, Andreas Hober, Fredrik Edfors, Veronique Chotteau, Per-Olof Berggren, Luigi Grassi, Aleksej Zelezniak, Thomas Svensson, Diane Hatton, Jens Nielsen, Jonathan L. Robinson, Johan Rockberg
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110936- (2022)
Summary: Recombinant protein production can cause severe stress on cellular metabolism, resulting in limited titer and product quality. To investigate cellular and metabolic characteristics associated with these limitations, we compare HEK293 clones
Externí odkaz:
https://doaj.org/article/039c0d28027d41c49243a52c9ff39b2d
Autor:
Suphitcha Limjiasahapong, Khwanta Kaewnarin, Narumol Jariyasopit, Sakchai Hongthong, Narong Nuntasaen, Jonathan L. Robinson, Intawat Nookaew, Yongyut Sirivatanauksorn, Chutima Kuhakarn, Vichai Reutrakul, Sakda Khoomrung
Publikováno v:
Frontiers in Plant Science, Vol 11 (2021)
Pyranonaphthoquinones (PNQs) are important structural scaffolds found in numerous natural products. Research interest in these specialized metabolites lies in their natural occurrence and therapeutic activities. Nonetheless, research progress has thu
Externí odkaz:
https://doaj.org/article/aabfc39543d345198188d3099b5f3c50
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2622-2635.e5 (2019)
Summary: The collection of proteins secreted from a cell—the secretome—is of particular interest in cancer pathophysiology due to its diagnostic potential and role in tumorigenesis. However, cancer secretome studies are often limited to one tissu
Externí odkaz:
https://doaj.org/article/e4d9d51f4d374975ac15a11219a32ecb
Publikováno v:
Metabolic Engineering Communications, Vol 1, Iss C, Pp 12-18 (2014)
The antimicrobial properties of nitric oxide (NO●) have motivated the design of NO●-releasing materials for the treatment and prevention of infection. The biological activity of NO● is dependent on its delivery rate, suggesting that variable an
Externí odkaz:
https://doaj.org/article/58759551db384c32bad0b75669e4564c
Publikováno v:
Bioengineering, Vol 3, Iss 1, p 9 (2016)
Enterohemorrhagic Escherichia coli (EHEC) are responsible for large outbreaks of hemorrhagic colitis, which can progress to life-threatening hemolytic uremic syndrome (HUS) due to the release of Shiga-like toxins (Stx). The presence of a functional n
Externí odkaz:
https://doaj.org/article/328c5525afdf4fb38482479398806eb6
Autor:
Mihail Anton, Eivind Almaas, Rui Benfeitas, Sara Benito-Vaquerizo, Lars M. Blank, Andreas Dräger, John M. Hancock, Cheewin Kittikunapong, Matthias König, Feiran Li, Ulf W. Liebal, Hongzhong Lu, Hongwu Ma, Radhakrishnan Mahadevan, Adil Mardinoglu, Jens Nielsen, Juan Nogales, Marco Pagni, Jason A. Papin, Kiran Raosaheb Patil, Nathan D. Price, Jonathan L. Robinson, Benjamín J. Sánchez, Maria Suarez-Diez, Snorre Sulheim, L. Thomas Svensson, Bas Teusink, Wanwipa Vongsangnak, Hao Wang, Ahmad A. Zeidan, Eduard J. Kerkhoven
The field of metabolic modelling at the genomescale continues to grow with more models being created and curated. This comes with an increasing demand for adopting common principles regarding transparency and versioning, in addition to standardisatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e77452cf0848a5f515f35c925440103
https://doi.org/10.1101/2023.03.21.512712
https://doi.org/10.1101/2023.03.21.512712
Autor:
Johan Gustafsson, Mihail Anton, Fariba Roshanzamir, Rebecka Jörnsten, Eduard J. Kerkhoven, Jonathan L. Robinson, Jens Nielsen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Single-cell RNA sequencing combined with genome-scale metabolic models (GEMs) has the potential to unravel the differences in metabolism across both cell types and cell states but requires new computational methods. Here, we present a method for gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0947ba1f56f4cbb938f4f1d3bbda495b
https://doi.org/10.1073/pnas.2217868120
https://doi.org/10.1073/pnas.2217868120
Energy metabolism of the brain is poorly understood partly due to the complex morphology of neurons. Here we used metabolic models that estimate costs of enzyme usage per pathway, enzyme utilization over time, and enzyme transport to evaluate a parad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ecd3e990ee12a161d55cd7744b3eb51
https://doi.org/10.1101/2022.11.14.516523
https://doi.org/10.1101/2022.11.14.516523
Autor:
Fariba Roshanzamir, Jonathan L. Robinson, Daniel Cook, Mohammad Hossein Karimi-Jafari, Jens Nielsen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(35)
Triple negative breast cancer (TNBC) metastases are assumed to exhibit similar functions in different organs as in the original primary tumor. However, studies of metastasis are often limited to a comparison of metastatic tumors with primary tumors o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9102774e26ac93c0996fca93ac1363d5
https://pubmed.ncbi.nlm.nih.gov/35994654
https://pubmed.ncbi.nlm.nih.gov/35994654