Výsledky vyhledávání - "Jonathan L. Metts"

Akademický článek

A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation

Autor: Jonathan L. Metts, Matteo Trucco, Daniel A. Weiser, Patrick Thompson, Eric Sandler, Tiffany Smith, Jessica Crimella, Samer Sansil, Ram Thapa, Brooke L. Fridley, Nicholas Llosa, Thomas Badgett, Richard Gorlick, Damon Reed, Jonathan Gill

Publikováno v: Cancer Medicine, Vol 12, Iss 4, Pp 4270-4281 (2023)

Abstract Background Patients with relapsed and refractory solid and central nervous system (CNS) tumors have poor outcomes and need novel therapeutic options. Vincristine, irinotecan, and temozolomide (VIT) is a common chemotherapy regimen in relapse

Externí odkaz: https://doaj.org/article/819f4342edbb4b839d42f66a42eadf95

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Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia

Autor: Himalee S. Sabnis, Tian Mi, Wandi Zhu, Heath L. Bradley, Jonathan L. Metts, Zhengqi Wang, Kevin D. Bunting, Jack L. Arbiser

Publikováno v: Antioxidants
Volume 10
Issue 6
Antioxidants, Vol 10, Iss 956, p 956 (2021)

Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d028237db65cee9a2fe226522018d3
https://pubmed.ncbi.nlm.nih.gov/34203664

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Hemophagocytic Lymphohistiocytosis Secondary to T Cell/Histiocyte-rich Large B Cell Lymphoma in an Adolescent Male

Autor: Sunita I. Park, Michael Briones, Frank G. Keller, Jonathan L. Metts

Publikováno v: Pediatric and Developmental Pathology. 21:95-99

Hemophagocytic Lymphohistiocytosis (HLH) is a hyperinflammatory disorder that may be encountered as a primary or secondary phenomenon. HLH secondary to lymphoma has been described, more frequently in adults than in children. T-cell/Histiocyte-rich B-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936bf1c9571b70ae2543b8321ef11b1a
https://doi.org/10.1177/1093526617699137

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Gemcitabine/nab-paclitaxel for pediatric relapsed/refractory sarcomas

Autor: Bradley George, Jonathan L. Metts, Adina Alazraki, Thomas Cash, Thomas A. Olson, Karen Wasilewski-Masker, Ernest K. Amankwah, Dana Clark

Publikováno v: Pediatric bloodcancer. 65(9)

Background Pediatric patients with relapsed/refractory sarcomas have poor outcomes and need novel therapies that provide disease control while maintaining an acceptable quality of life. The activity and toxicity of gemcitabine and nab-paclitaxel in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ab6b1819b0ed466818d69a0008df94
https://pubmed.ncbi.nlm.nih.gov/29770997

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Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells

Autor: Reuben Kapur, Jack L. Arbiser, Neil P. Shah, Jonathan L. Metts, Zhengqi Wang, Kevin D. Bunting, Heath L. Bradley

Publikováno v: Scientific reports, vol 7, iss 1
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports

Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, however, drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50373363b390e1cfe0c3c189aa572bda
https://escholarship.org/uc/item/3j87x6gk

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Concurrent myeloid sarcoma, atypical teratoid/rhabdoid tumor, and hypereosinophilia in an infant with a germline SMARCB1 mutation

Autor: Jaclyn A. Biegel, Bruno P. Soares, Sunita I. Park, Jonathan L. Metts, Cindy Y Fong, Kelly C. Goldsmith

Publikováno v: Pediatric bloodcancer. 64(9)

We report a 1-year-old female child presenting with hypereosinophilia who was found to have concurrent myeloid sarcoma and a central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT). She was later found to have a germline mutation in SMA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13f86210a8787e61422410e03742a2b
https://pubmed.ncbi.nlm.nih.gov/28111898

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Imipramine Blue Sensitively and Selectively Targets FLT3 and c-Kit Mutant Acute Myeloid Leukemia

Autor: Jonathan L. Metts, Kevin D. Bunting, Heath L. Bradley, Reuben Kapur, Jack L. Arbiser, Neil P. Shah

Publikováno v: Blood. 126:3688-3688

Acute myeloid leukemia (AML) is the most common acute leukemia in adults and the 2nd most common in children. Despite advances in our understanding of AML biology, long term survival remains suboptimal. Current therapy primarily involves high dose cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2c119d14c18cd90f9bf590473f2a6ff
https://doi.org/10.1182/blood.v126.23.3688.3688

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Burkitt Lymphoma Has Lower CD58 Expression Than Other B Cell Malignancies in Children

Autor: Silvia T. Bunting, Jonathan L. Metts, Traci Leong, Sunita I. Park, Elizabeth Weinzierl

Publikováno v: Blood. 126:5011-5011

Introduction: Burkitt Lymphoma (BL) is a highly aggressive mature B cell neoplasm comprising 30% of Non-Hodgkin lymphoma in children. BL can be difficult to discriminate from other mature B cell lymphomas, and distinguishing BL from Diffuse Large B C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::deaf60c1d3e8a46337ab5e9d00994221
https://doi.org/10.1182/blood.v126.23.5011.5011

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