Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jonathan L. Linehan"'
Autor:
Yaíma L. Lightfoot, Saeko Nakajima, Verena M. Link, Samira Tamoutounour, Oliver J. Harrison, Christopher K. E. Bleck, Mariana J. Kaplan, E. Merrill, Jonathan L. Linehan, Margery G. Smelkinson, Seong-Ji Han, Yasmine Belkaid, C. Hurabielle, Nicolas Bouladoux, Nickie L Seto, Michail S. Lionakis
Publikováno v:
Proc Natl Acad Sci U S A
Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebac6fa576b6f186dd0e7130d2a41faf
https://doi.org/10.1073/pnas.2003022117
https://doi.org/10.1073/pnas.2003022117
Autor:
Jonathan L. Linehan, Dmitri I. Kotov, Marc K. Jenkins, Jessica A. Kotov, Micah D. Gearhart, Vivian J. Bardwell
Publikováno v:
The Journal of Experimental Medicine
Th17 cells provide a protective immunity against extracellular bacterial and fungal pathogens. Kotov et al. identify and characterize a mechanism by which BCOR promotes Th17 formation after Streptococcus pyogenes infection by repressing genes that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c692aec08524db02b8ca4abd7a28e4
https://doi.org/10.1084/jem.20182376
https://doi.org/10.1084/jem.20182376
Autor:
Elizabeth B. Norton, Amrita Bhattacharjee, Denise Morais da Fonseca, Yasmine Belkaid, Sean P. Spencer, Oliver J. Harrison, Abigail E. Overacre-Delgoffe, Justin T. Tometich, Ansen H.P. Burr, Timothy W. Hand, Jason A. Hall, Deyi Yang, Brydie R. Huckestein, Jonathan L. Linehan
SummaryEnvironmental Enteric Dysfunction (EED) is an intestinal disease caused by malnutrition and infection that leads to malabsorption and stunting. EED is also associated with a reduced efficacy of oral vaccines. We show in a microbiota and diet-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::178b4956afd467f519303ac1c36fb567
https://doi.org/10.1101/2020.06.03.130831
https://doi.org/10.1101/2020.06.03.130831
Autor:
Brydie R. Huckestein, Oliver J. Harrison, Deyi Yang, Ansen H.P. Burr, Justin T. Tometich, Jason A. Hall, Sean P. Spencer, Elizabeth B. Norton, Jonathan L. Linehan, Yasmine Belkaid, Amrita Bhattacharjee, Denise Morais da Fonseca, Abigail E. Overacre-Delgoffe, Timothy W. Hand
Publikováno v:
Immunity
Summary Environmental enteric dysfunction (EED) is a gastrointestinal inflammatory disease caused by malnutrition and chronic infection. EED is associated with stunting in children and reduced efficacy of oral vaccines. To study the mechanisms of ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4904a8b23ac488a38a9d445a0de9444b
https://pubmed.ncbi.nlm.nih.gov/34348118
https://pubmed.ncbi.nlm.nih.gov/34348118
Autor:
Thamotharampillai Dileepan, Jonathan L Linehan, James J Moon, Marion Pepper, Marc K Jenkins, Patrick P Cleary
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002252 (2011)
Group A streptococcus (GAS, Streptococcus pyogenes) is the cause of a variety of clinical conditions, ranging from pharyngitis to autoimmune disease. Peptide-major histocompatibility complex class II (pMHCII) tetramers have recently emerged as a high
Externí odkaz:
https://doaj.org/article/d814d7e28b4942138c32dea9b1a9f51e
Autor:
Jonathan L. Linehan, Paula Juliana Pérez-Chaparro, Barbara Rehermann, Oliver J. Harrison, Ivan Vujkovic-Cvijin, Vanja Lazarevic, Michael G. Constantinides, Samira Tamoutounour, Julie Deckers, Seong-Ji Han, Nicolas Bouladoux, Stephan P. Rosshart, C. Hurabielle, Verena M. Link, Yasmine Belkaid
Publikováno v:
Proc Natl Acad Sci U S A
The cross-talk between the microbiota and the immune system plays a fundamental role in the control of host physiology. However, the tissue-specific factors controlling this dialogue remain poorly understood. Here we demonstrate that T cell responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40a77acd98df21ba19a759b971a4ea9
https://pubmed.ncbi.nlm.nih.gov/31672911
https://pubmed.ncbi.nlm.nih.gov/31672911
Autor:
Tiffany C. Scharschmidt, Yasmine Belkaid, Sepideh Farhat, E. Dean Merrill, Andrea C. Wong, Samira Tamoutounour, Kelin Li, Michael G. Constantinides, Ivan Vujkovic-Cvijin, Jonathan L. Linehan, Antonin Weckel, Jeffrey Aubé, Avinash Bhandoola, Verena M. Link, Sobhan Roy, Daniel J. Cua, Siddharth R. Krishnamurthy, Erin J. Adams, Michael A. Fischbach, P. Juliana Perez-Chaparro, Nicolas Bouladoux, Seong-Ji Han, Y. Erin Chen
Publikováno v:
Science (New York, N.Y.), vol 366, iss 6464
Commensals rule the MAITrix Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT cells recognize microbial small molecules presented by the major histocompatibility complex class Ib molecule MR1. MAIT cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f0834252303e9b09428e3de1d93ab5
Autor:
Sarada L. Nandiwada, Deepali Malhotra, M. Gerard O'Sullivan, Marc K. Jenkins, Shirdi E. Schmiel, Lokesh A. Kalekar, Daniel L. Mueller, Kristin A. Hogquist, Gretta L. Stritesky, Laura O. Barsness, Brian T. Fife, Na Zhang, Wing Y Lam, Kristen E. Pauken, Jonathan L. Linehan
Publikováno v:
Nature immunology
The role of anergy, an acquired state of T cell functional unresponsiveness, in natural peripheral tolerance remains unclear. In this study, we found that anergy was selectively induced in fetal antigen-specific maternal CD4(+) T cells during pregnan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ebeafa1ab41ae22bfbf8464fbf64cd
https://doi.org/10.1038/ni.3331
https://doi.org/10.1038/ni.3331
Autor:
Rosalba Salcedo, Nicholas Collins, Chen Yao, Jonathan L. Linehan, Margery G. Smelkinson, Andrea Paun, Samira Tamoutounour, Shurjo K. Sen, Seong-Ji Han, Francois Van Laethem, John J. O'Shea, Michel Enamorado, Oliver J. Harrison, Yasmine Belkaid, Han-Yu Shih, Allyson L. Byrd, Nicolas Bouladoux, C. Hurabielle
Publikováno v:
Science (New York, N.Y.). 363(6422)
Commensal-specific T cells are flexible Barrier tissues, like the skin, are sites where noninvasive commensal microbes constantly interact with resident T cells. These encounters can result in commensal-specific T cell responses that promote, for exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb099f409b17928536f6916b2365f756
https://pubmed.ncbi.nlm.nih.gov/30889396
https://pubmed.ncbi.nlm.nih.gov/30889396
Autor:
Lélia Delamarre, Jonathan L. Linehan
Publikováno v:
Nature. 574:639-640
Immunotherapy treatment harnesses CD8 T cells of the immune system to kill tumour cells. The finding that CD4 helper T cells contribute to the success of this treatment in mice might offer a way to improve clinical outcomes. CD4 T cells boost the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0740c87a8f31139eed9a10724cbb12d9
https://doi.org/10.1038/d41586-019-03106-1
https://doi.org/10.1038/d41586-019-03106-1