Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jonathan L. Chen"'
Autor:
Pnina Gottfried Komlosh, Jonathan L. Chen, Jessica Childs-Disney, Matthew D. Disney, Dan Canaani
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Previously, we have identified a novel human metastasis-inducing lncRNA (named SKAI1BC), that suppresses the KAI1/CD82 metastasis-suppressing gene and is upregulated in triple negative breast cancer and melanoma derived cell lines. Modeling
Externí odkaz:
https://doaj.org/article/0468ffd7c3734edf826ecdf9677d735b
Autor:
Hafeez S. Haniff, Yuquan Tong, Xiaohui Liu, Jonathan L. Chen, Blessy M. Suresh, Ryan J. Andrews, Jake M. Peterson, Collin A. O’Leary, Raphael I. Benhamou, Walter N. Moss, Matthew D. Disney
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1713-1721 (2020)
Externí odkaz:
https://doaj.org/article/7d0b00c666094ff5a93e78d8eb1ef1ed
Publikováno v:
Methods in Molecular Biology ISBN: 9781071631904
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fab01df71dd328c19eb2f69566be3242
https://doi.org/10.1007/978-1-0716-3191-1_14
https://doi.org/10.1007/978-1-0716-3191-1_14
Autor:
Jeffrey D. Rothstein, Jonathan L. Chen, Montina Van Meter, Tania F. Gendron, Alyssa N. Coyne, Yong Jie Zhang, Eric T. Wang, Yue Li, Ilyas Yildirim, Rita Fuerst, Jessica A. Bush, Leonard Petrucelli, Samantha M. Meyer, Hailey Olafson, Jessica L. Childs-Disney, Kye Won Wang, Yuquan Tong, Kendra K. McKee, Raphael I. Benhamou, Tanya Khan, Andrei Ursu, Matthew D. Disney, Sarah Wagner-Griffin, Haruo Aikawa
Publikováno v:
Sci Transl Med
The most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD) is an expanded G(4)C(2) RNA repeat [r(G(4)C(2))(exp)] in chromosome 9 open reading frame 72 (C9orf72), which elicits pathology through several mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c7323437f11575a5a155e154c7f4b4
https://europepmc.org/articles/PMC9533739/
https://europepmc.org/articles/PMC9533739/
Autor:
Jessica L. Childs-Disney, Alicia J. Angelbello, Matthew D. Disney, Sarah Wagner-Griffin, Raphael I. Benhamou, Jonathan L. Chen, Kamalakannan Vishnu, Masahito Abe
Publikováno v:
J Med Chem
Myotonic dystrophy type 2 (DM2) is one of >40 microsatellite disorders caused by RNA repeat expansions. The DM2 repeat expansion, r(CCUG)(exp) (where “exp” denotes expanded repeating nucleotides), is harbored in intron 1 of the CCHC-type zinc fin
Publikováno v:
Ann N Y Acad Sci
Aberrant RNA structure and function operate in neurological disease progression and severity. As RNA contributes to disease pathology in a complex fashion, that is, via various mechanisms, it has become an attractive therapeutic target for small mole
Publikováno v:
Epitranscriptomics ISBN: 9783030716110
Pseudouridylation is perhaps the most common epitranscriptomic modification among over 170 known chemical RNA modifications. Pseudouridine (Ψ) is highly conserved in various stable RNAs of all organisms. RNA pseudouridylation can be catalyzed by an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb31f5408875b1d8a44c67f92ae8f3f1
https://doi.org/10.1007/978-3-030-71612-7_19
https://doi.org/10.1007/978-3-030-71612-7_19
Autor:
Andrei Ursu, Tania F. Gendron, Ilyas Yildirim, Kye Won Wang, Jonathan L. Chen, Shruti Choudhary, Jessica A. Bush, Jared T. Baisden, Yong Jie Zhang, Matthew D. Disney, Leonard Petrucelli
Publikováno v:
ACS Chem Biol
Genetically defined amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), collectively named c9ALS/FTD, are triggered by hexanucleotide GGGGCC repeat expansions [r(G(4)C(2))(exp)] within the C9orf 72 gene. In these diseases, neuronal
Autor:
Xiaohui Liu, Jake Peterson, Raphael I. Benhamou, Walter N. Moss, Blessy M Suresh, Matthew D. Disney, Ryan J. Andrews, Collin A. O’Leary, Yuquan Tong, Jonathan L. Chen, Hafeez S. Haniff
Publikováno v:
ACS Central Science
ACS Central Science, Vol 6, Iss 10, Pp 1713-1721 (2020)
ACS Central Science, Vol 6, Iss 10, Pp 1713-1721 (2020)
COVID-19 is a global pandemic, thus requiring multiple strategies to develop modalities against it. Herein, we designed multiple bioactive small molecules that target a functional structure within the SARS-CoV-2’s RNA genome, the causative agent of
Publikováno v:
SLAS Discov
RNA molecules have a variety of cellular functions that can drive disease pathologies. They are without a doubt one of the most intriguing yet controversial small-molecule drug targets. The ability to widely target RNA with small molecules could be r