Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jonathan L Robinson"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 4, p e1008898 (2021)
Deregulation of the protein secretory pathway (PSP) is linked to many hallmarks of cancer, such as promoting tissue invasion and modulating cell-cell signaling. The collection of secreted proteins processed by the PSP, known as the secretome, is ofte
Externí odkaz:
https://doaj.org/article/bb7281432f284142ad475ee895eb4178
Autor:
Johan Gustafsson, Felix Held, Jonathan L Robinson, Elias Björnson, Rebecka Jörnsten, Jens Nielsen
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239495 (2020)
Cell-type specific gene expression profiles are needed for many computational methods operating on bulk RNA-Seq samples, such as deconvolution of cell-type fractions and digital cytometry. However, the gene expression profile of a cell type can vary
Externí odkaz:
https://doaj.org/article/2a59eb2ff267438495cba19c49e154ee
Autor:
Alireza Azimi, Stefano Caramuta, Brinton Seashore‐Ludlow, Johan Boström, Jonathan L Robinson, Fredrik Edfors, Rainer Tuominen, Kristel Kemper, Oscar Krijgsman, Daniel S Peeper, Jens Nielsen, Johan Hansson, Suzanne Egyhazi Brage, Mikael Altun, Mathias Uhlen, Gianluca Maddalo
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 3, Pp 1-16 (2018)
Abstract Novel therapies are undergoing clinical trials, for example, the Hsp90 inhibitor, XL888, in combination with BRAF inhibitors for the treatment of therapy‐resistant melanomas. Unfortunately, our data show that this combination elicits a het
Externí odkaz:
https://doaj.org/article/6c5b851e266f45048761038c0f72ccff
Autor:
Jonathan L Robinson, Mark P Brynildsen
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 5, p e1003049 (2013)
Nitric oxide (NO•) is generated by the innate immune response to neutralize pathogens. NO• and its autoxidation products have an extensive biochemical reaction network that includes reactions with iron-sulfur clusters, DNA, and thiols. The fate o
Externí odkaz:
https://doaj.org/article/7c3eb95b9dd845a399c9022c4e927654
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2622-2635.e5 (2019)
Summary: The collection of proteins secreted from a cell—the secretome—is of particular interest in cancer pathophysiology due to its diagnostic potential and role in tumorigenesis. However, cancer secretome studies are often limited to one tissu
Externí odkaz:
https://doaj.org/article/e4d9d51f4d374975ac15a11219a32ecb
Autor:
Mihail Anton, Eivind Almaas, Rui Benfeitas, Sara Benito-Vaquerizo, Lars M. Blank, Andreas Dräger, John M. Hancock, Cheewin Kittikunapong, Matthias König, Feiran Li, Ulf W. Liebal, Hongzhong Lu, Hongwu Ma, Radhakrishnan Mahadevan, Adil Mardinoglu, Jens Nielsen, Juan Nogales, Marco Pagni, Jason A. Papin, Kiran Raosaheb Patil, Nathan D. Price, Jonathan L. Robinson, Benjamín J. Sánchez, Maria Suarez-Diez, Snorre Sulheim, L. Thomas Svensson, Bas Teusink, Wanwipa Vongsangnak, Hao Wang, Ahmad A. Zeidan, Eduard J. Kerkhoven
The field of metabolic modelling at the genomescale continues to grow with more models being created and curated. This comes with an increasing demand for adopting common principles regarding transparency and versioning, in addition to standardisatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e77452cf0848a5f515f35c925440103
https://doi.org/10.1101/2023.03.21.512712
https://doi.org/10.1101/2023.03.21.512712
Autor:
Johan Gustafsson, Mihail Anton, Fariba Roshanzamir, Rebecka Jörnsten, Eduard J. Kerkhoven, Jonathan L. Robinson, Jens Nielsen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Single-cell RNA sequencing combined with genome-scale metabolic models (GEMs) has the potential to unravel the differences in metabolism across both cell types and cell states but requires new computational methods. Here, we present a method for gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0947ba1f56f4cbb938f4f1d3bbda495b
https://doi.org/10.1073/pnas.2217868120
https://doi.org/10.1073/pnas.2217868120
Energy metabolism of the brain is poorly understood partly due to the complex morphology of neurons. Here we used metabolic models that estimate costs of enzyme usage per pathway, enzyme utilization over time, and enzyme transport to evaluate a parad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ecd3e990ee12a161d55cd7744b3eb51
https://doi.org/10.1101/2022.11.14.516523
https://doi.org/10.1101/2022.11.14.516523
Autor:
Fariba Roshanzamir, Jonathan L. Robinson, Daniel Cook, Mohammad Hossein Karimi-Jafari, Jens Nielsen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(35)
Triple negative breast cancer (TNBC) metastases are assumed to exhibit similar functions in different organs as in the original primary tumor. However, studies of metastasis are often limited to a comparison of metastatic tumors with primary tumors o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9102774e26ac93c0996fca93ac1363d5
https://pubmed.ncbi.nlm.nih.gov/35994654
https://pubmed.ncbi.nlm.nih.gov/35994654
Autor:
Johan Gustafsson, Fariba Roshanzamir, Anders Hagnestål, Sagar M. Patel, Oseeyi I. Daudu, Donald F. Becker, Jonathan L. Robinson, Jens Nielsen
The tumor microenvironment is comprised of a complex mixture of different cell types interacting under conditions of nutrient deprivation, but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34e8f0719fb8421a93d6d10102ea60f
https://doi.org/10.1101/2022.02.08.479584
https://doi.org/10.1101/2022.02.08.479584