Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling.

Autor: Jianjun Hu, Jie Lu, Gewei Lian, Jingping Zhang, Jonathan L Hecht, Volney L Sheen

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89352 (2014)

Humans who harbor loss of function mutations in the actin-associated filamin B (FLNB) gene develop spondylocarpotarsal syndrome (SCT), a disorder characterized by dwarfism (delayed bone formation) and premature fusion of the vertebral, carpal and tar

Externí odkaz: https://doaj.org/article/825da0645c334886a50307f8e7b09bcc

Associations between prediagnostic aspirin use and ovarian tumor gene expression

Autor: Naoko Sasamoto, Paul A. Stewart, Tianyi Wang, Zachary J. Thompson, Sean J. Yoder, Jonathan L. Hecht, John L. Cleveland, Jose Conejo‐Garcia, Brooke L. Fridley, Kathryn L. Terry, Shelley S. Tworoger

Publikováno v: Cancer Medicine, Vol 12, Iss 17, Pp 18405-18417 (2023)

Abstract Background Aspirin use has been associated with reduced ovarian cancer risk, yet the underlying biological mechanisms are not fully understood. To gain mechanistic insights, we assessed the association between prediagnosis low and regular‐

Externí odkaz: https://doaj.org/article/4e60807f476e4be1828c4fc2a22e7d83

Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19

Autor: Na Wang, Marta Vuerich, Ahmadreza Kalbasi, Jonathon J. Graham, Eva Csizmadia, Zachary James Manickas-Hill, Ann Woolley, Clement David, Eric M. Miller, Kara Gorman, Jonathan L. Hecht, Shahzad Shaefi, Simon C. Robson, Maria Serena Longhi

Publikováno v: iScience, Vol 24, Iss 10, Pp 103205- (2021)

Summary: T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, l

Externí odkaz: https://doaj.org/article/03da945e58204d69bd6bcc6513eaad77

CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma

Autor: Eun-Young, Kang, Ashley, Weir, Nicola S, Meagher, Kyo, Farrington, Gregg S, Nelson, Prafull, Ghatage, Cheng-Han, Lee, Marjorie J, Riggan, Adelyn, Bolithon, Gordana, Popovic, Betty, Leung, Katrina, Tang, Neil, Lambie, Joshua, Millstein, Jennifer, Alsop, Michael S, Anglesio, Beyhan, Ataseven, Ellen, Barlow, Matthias W, Beckmann, Jessica, Berger, Christiani, Bisinotto, Hans, Bösmüller, Jessica, Boros, Alison H, Brand, Angela, Brooks-Wilson, Sara Y, Brucker, Michael E, Carney, Yovanni, Casablanca, Alicia, Cazorla-Jiménez, Paul A, Cohen, Thomas P, Conrads, Linda S, Cook, Penny, Coulson, Madeleine, Courtney-Brooks, Daniel W, Cramer, Philip, Crowe, Julie M, Cunningham, Cezary, Cybulski, Kathleen M, Darcy, Mona A, El-Bahrawy, Esther, Elishaev, Ramona, Erber, Rhonda, Farrell, Sian, Fereday, Anna, Fischer, María J, García, Simon A, Gayther, Aleksandra, Gentry-Maharaj, C Blake, Gilks, Marcel, Grube, Paul R, Harnett, Shariska Petersen, Harrington, Philipp, Harter, Arndt, Hartmann, Jonathan L, Hecht, Sebastian, Heikaus, Alexander, Hein, Florian, Heitz, Joy, Hendley, Brenda Y, Hernandez, Susanna Hernando, Polo, Sabine, Heublein, Akira, Hirasawa, Estrid, Høgdall, Claus K, Høgdall, Hugo M, Horlings, David G, Huntsman, Tomasz, Huzarski, Andrea, Jewell, Mercedes, Jimenez-Linan, Michael E, Jones, Scott H, Kaufmann, Catherine J, Kennedy, Dineo, Khabele, Felix K F, Kommoss, Roy F P M, Kruitwagen, Diether, Lambrechts, Nhu D, Le, Marcin, Lener, Jenny, Lester, Yee, Leung, Anna, Linder, Liselore, Loverix, Jan, Lubiński, Rashna, Madan, G Larry, Maxwell, Francesmary, Modugno, Susan L, Neuhausen, Alexander, Olawaiye, Siel, Olbrecht, Sandra, Orsulic, José, Palacios, Celeste Leigh, Pearce, Malcolm C, Pike, Carmel M, Quinn, Ganendra Raj, Mohan, Cristina, Rodríguez-Antona, Matthias, Ruebner, Andy, Ryan, Stuart G, Salfinger, Naoko, Sasamoto, Joellen M, Schildkraut, Minouk J, Schoemaker, Mitul, Shah, Raghwa, Sharma, Yurii B, Shvetsov, Naveena, Singh, Gabe S, Sonke, Linda, Steele, Colin J R, Stewart, Karin, Sundfeldt, Anthony J, Swerdlow, Aline, Talhouk, Adeline, Tan, Sarah E, Taylor, Kathryn L, Terry, Aleksandra, Tołoczko, Nadia, Traficante, Koen K, Van de Vijver, Maaike A, van der Aa, Toon, Van Gorp, Els, Van Nieuwenhuysen, Lilian, van-Wagensveld, Ignace, Vergote, Robert A, Vierkant, Chen, Wang, Lynne R, Wilkens, Stacey J, Winham, Anna H, Wu, Javier, Benitez, Andrew, Berchuck, Francisco J, Candido Dos Reis, Anna, DeFazio, Peter A, Fasching, Ellen L, Goode, Marc T, Goodman, Jacek, Gronwald, Beth Y, Karlan, Stefan, Kommoss, Usha, Menon, Hans-Peter, Sinn, Annette, Staebler, James D, Brenton, David D, Bowtell, Paul D P, Pharoah, Susan J, Ramus, Martin, Köbel

Publikováno v: Cancer, 129(5), 697-713. Wiley
Cancer: interdisciplinary international journal of the American Cancer Society

BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a712f975eda37f30b27613bbb4a613d2
https://cris.maastrichtuniversity.nl/en/publications/c478396c-2f30-41bf-8d8e-e8eb052ddffb

The pathology of eclampsia: An autopsy series

Autor: Jonathan L. Hecht, Jaume Ordi, Carla Carrilho, Mamudo R. Ismail, Zsuzsanna K. Zsengeller, S. Ananth Karumanchi, Seymour Rosen

Publikováno v: Hypertension in Pregnancy, Vol 36, Iss 3, Pp 259-268 (2017)

Objective: We describe the main lesions in the liver, brain, and kidney from autopsies of women who died of eclampsia and characterize the endothelial injury. Methods: Cases were identified from a study involving 317 maternal deaths (2003–2006) con

Externí odkaz: https://doaj.org/article/0d7c392237744b5ea0d66300d1dd2ec4