Nasal cathelicidin is expressed in early life and is increased during mild, but not severe respiratory syncytial virus infection

Autor: Sofia Sintoris, Justyna M. Binkowska, Jonathan L. Gillan, Roy P. Zuurbier, Jonathan Twynam-Perkins, Maartje Kristensen, Lauren Melrose, Paula Lusaretta Parga, Alicia Ruiz Rodriguez, Mei Ling Chu, Sara R. van Boeckel, Joanne G. Wildenbeest, Dawn M. E. Bowdish, Andrew J. Currie, Ryan S. Thwaites, Jurgen Schwarze, Marlies A. van Houten, James P. Boardman, Steve Cunningham, Debby Bogaert, Donald J. Davidson

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract Respiratory syncytial virus is the major cause of acute lower respiratory tract infections in young children, causing extensive mortality and morbidity globally, with limited therapeutic or preventative options. Cathelicidins are innate immu

Externí odkaz: https://doaj.org/article/7a315c29b5364d6da9023a1485e4aecf

CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages

Autor: Jonathan L. Gillan, Mithil Chokshi, Gareth R. Hardisty, Sara Clohisey Hendry, Daniel Prasca-Chamorro, Nicola J. Robinson, Benjamin Lasota, Richard Clark, Lee Murphy, Moira K. B. Whyte, J. Kenneth Baillie, Donald J. Davidson, Gang Bao, Robert D. Gray

Publikováno v: Gillan, J L, Chokshi, M, Hardisty, G R, Clohisey Hendry, S, Prasca-Chamorro, D, Robinson, N J, Lasota, B, Clark, R, Murphy, L, Whyte, M K B, Baillie, J K, Davidson, D J, Bao, G & Gray, R D 2023, ' CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages ', Science Advances, vol. 9, no. 21, eadg5128, pp. 1-17 . https://doi.org/10.1126/sciadv.adg5128

An intense, nonresolving airway inflammatory response leads to destructive lung disease in cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet governing the progression of CF lung disease, but the underlying mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1d6f49036f9327fdf6f94531d99523
https://www.pure.ed.ac.uk/ws/files/350052675/sciadv.adg5128.pdf

High Purity Isolation of Low Density Neutrophils Casts Doubt on Their Exceptionality in Health and Disease

Autor: Frances Llanwarne, Robert D. Gray, Gareth Hardisty, Emily Gwyer Findlay, Danielle Minns, Donald J. Davidson, Jonathan L Gillan

Publikováno v: Frontiers in Immunology
Hardisty, G, Llanwarne, F, Minns, D, Gillan, J, Davidson, D J, Gwyer Findlay, E L & Gray, R D 2021, ' High purity isolation of low density neutrophils casts doubt on their exceptionality in health and disease ', Frontiers in Immunology, vol. 12, 625922 . https://doi.org/10.3389/fimmu.2021.625922
Frontiers in Immunology, Vol 12 (2021)

Low density neutrophils (LDNs) are described in a number of inflammatory conditions, cancers and infections and associated with immunopathology, and a mechanistic role in disease. The role of LDNs at homeostasis in healthy individuals has not been in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f06960c23fa553b2e107725173da9f
https://pubmed.ncbi.nlm.nih.gov/34168640

Ultra-pure isolation of low density neutrophils casts doubt on their exceptionality in health and disease

Autor: Donald J. Davidson, Emily R Gwyer Findlay, Frances Llanwarne, Robert D. Gray, Jonathan L Gillan, Gareth Hardisty, Danielle Minns

Low density neutrophils (LDNs) are described in a number of inflammatory conditions, cancers and infections and associated with immunopathology, and a mechanistic role in disease. The role of LDNs at homeostasis in healthy individuals has not been in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6df8d83398e537d3fbc067519f1f6de0
https://doi.org/10.1101/2020.06.17.156588

350: Elexacaftor-tezacaftor-ivacaftor treatment fundamentally changes the inflammatory landscape in people with CF

Autor: N.J. Robinson, Robert D. Gray, Gareth Hardisty, Jonathan L Gillan, L. Hunt

Publikováno v: Journal of Cystic Fibrosis. 20:S167

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f5e8cc72d0ddbc98ebe8a32e9b49142
https://doi.org/10.1016/s1569-1993(21)01774-4