Výsledky vyhledávání - "Jonathan L E Dean"

Akademický článek

Heat shock protein B1-deficient mice display impaired wound healing.

Autor: Jonathan Crowe, Anna Aubareda, Kay McNamee, Paulina M Przybycien, Xin Lu, Richard O Williams, George Bou-Gharios, Jeremy Saklatvala, Jonathan L E Dean

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77383 (2013)

There is large literature describing in vitro experiments on heat shock protein (hsp)B1 but understanding of its function in vivo is limited to studies in mice overexpressing human hspB1 protein. Experiments in cells have shown that hspB1 has chapero

Externí odkaz: https://doaj.org/article/5e0d1e534624428a84b6788f6b5660f1

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The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases

Autor: Andrew R, Clark, Jonathan L E, Dean

Publikováno v: Biochemical Society Transactions

Twenty years ago, the first description of a tristetraprolin (TTP) knockout mouse highlighted the fundamental role of TTP in the restraint of inflammation. Since then, work from several groups has generated a detailed picture of the expression and fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03df76def78873b3bd850265e9cb2492
https://pubmed.ncbi.nlm.nih.gov/27911715

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Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis

Autor: Fiona E, McCann, Dany P, Perocheau, Gerhard, Ruspi, Katrina, Blazek, Marie L, Davies, Marc, Feldmann, Jonathan L E, Dean, A Allart, Stoop, Richard O, Williams

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 66(10)

Tumor necrosis factor (TNF) signals via 2 receptors, TNFR type I (TNFRI) and TNFRII, with distinct cellular distribution and signaling functions. In rheumatoid arthritis (RA), the net effect of TNFR signaling favors inflammatory responses while inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::487d0982a982d4824b25f4e75bc1933a
https://pubmed.ncbi.nlm.nih.gov/24965881

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NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

Autor: Karine, Enesa, Mustafa, Zakkar, Hera, Chaudhury, Le A, Luong, Lesley, Rawlinson, Justin C, Mason, Dorian O, Haskard, Jonathan L E, Dean, Paul C, Evans

Publikováno v: The Journal of biological chemistry. 283(11)

Transcription factors belonging to the NF-kappaB family regulate inflammation by inducing pro-inflammatory molecules (e.g. interleukin (IL)-8) in response to cytokines (e.g. tumor necrosis factor (TNF) alpha, IL-1) or other stimuli. Several negative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb12c4af2c1684270238e2ed861ab883
https://pubmed.ncbi.nlm.nih.gov/18178551

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