FASTAptamer: A Bioinformatic Toolkit for High-throughput Sequence Analysis of Combinatorial Selections

Autor: Khalid K Alam, Jonathan L Chang, Donald H Burke

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)

High-throughput sequence (HTS) analysis of combinatorial selection populations accelerates lead discovery and optimization and offers dynamic insight into selection processes. An underlying principle is that selection enriches high-fitness sequences

Externí odkaz: https://doaj.org/article/585fd37d641f492c8f349de2cadf3437

A 23-Year-Old Man With Multisystem Inflammatory Syndrome After Mild COVID-19

Autor: Alexander C. Razavi MPH, Jonathan L. Chang MD, Aimee Sutherland MD, MPH, Anjali Niyogi MD, MPH, Geraldine E. Ménard MD

Publikováno v: Journal of Investigative Medicine High Impact Case Reports, Vol 8 (2020)

We present the case of a young obese patient with recent COVID-19 (coronavirus disease 2019) who developed multisystem inflammatory syndrome (MIS) 1 month after spontaneous resolution. A 23-year-old African American man was admitted with a 1-week his

Externí odkaz: https://doaj.org/article/6babb787c9954706a66c0f9d82c48a42

Treated HIV Infection and Progression of Carotid Atherosclerosis in Rural Uganda: A Prospective Observational Cohort Study

Autor: David R. Bangsberg, Bernard Kakuhikire, Mark J. Siedner, Douglas S. Kwon, Isabelle T. Yang, Robert N. Peck, Crystal M. North, Jessica E. Haberer, Jonathan L. Chang, Chris T. Longenecker, Jeffrey N. Martin, Samson Okello, Brian B. Ghoshhajra, June-Ho Kim, Linda C. Hemphill, Ruth Sentongo, Alexander Lankowski, Rebecca F Gilbert, Russell P. Tracy, Prossy Bibangambah, Virginia A. Triant, Yap Boum, Peter W. Hunt, Alexander C. Tsai

Publikováno v: Journal of the American Heart Association, vol 10, iss 12
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Although ≈70% of the world's population of people living with HIV reside in sub‐Saharan Africa, there are minimal prospective data on the contributions of HIV infection to atherosclerosis in the region. Methods and Results We conducted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea587359fb8cccc893df16c748fb6ba3
https://doi.org/10.1161/jaha.120.019994

Poly-Target Selection Identifies Broad-Spectrum RNA Aptamers

Autor: Jonathan L. Chang, Donald H. Burke, Phuong D.M. Nguyen, Margaret J. Lange, Khalid K. Alam, Andrew W. Sawyer

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 605-619 (2018)
Molecular Therapy. Nucleic Acids

Aptamer selections often yield distinct subpopulations, each with unique phenotypes that can be leveraged for specialized applications. Although most selections aim to attain ever higher specificity, we sought to identify aptamers that recognize incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2958b555a09690cea675a0910fc226d2
http://www.sciencedirect.com/science/article/pii/S2162253118302816

CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies

Autor: Peter W. Hunt, David R. Bangsberg, Deanna L. Kroetz, Jessica E. Haberer, Jonathan L. Chang, Conrad Muzoora, Yap Boum, Mark J. Siedner, Jeffrey N. Martin, Nicholas Musinguzi, Alexander C. Tsai, Sulggi A. Lee, Bosco M Bwana

Publikováno v: AIDS research and human retroviruses, vol 34, iss 11

Single-nucleotide polymorphisms (SNPs) in CYP2B6 have been shown to predict variation in plasma efavirenz concentrations, but associations between these SNPs and efavirenz-mediated depression and viral suppression are less well described. We evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2464854bc49b11d34bba18cf4631cf4
https://doi.org/10.1089/aid.2018.0062