Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Jonathan L, Quanson"'
1
Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone
Autor: Riaan Ehlers, Amanda C. Swart, Liezl M. Bloem, Antonio Serafin, Jonathan L. Quanson, Therina du Toit
Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 166:54-67
Adrenal C19 steroids serve as precursors to active androgens in the prostate. Androstenedione (A4), 11β-hydroxyandrostenedione (11OHA4) and 11β-hydroxytestosterone (11OHT) are metabolised to potent androgen receptor (AR) agonists, dihydrotestostero
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcb97d96c6d4cc1a821729cfc25b70c4
https://doi.org/10.1016/j.jsbmb.2016.06.009
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2
11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): Implications for castration resistant prostate cancer
Autor: Elzette Pretorius, Karl-Heinz Storbeck, Jacky L. Snoep, Elahe A. Mostaghel, Jonathan L. Quanson, Monique Barnard
Publikováno v: Journal of Steroid Biochemistry and Molecular Biology, 183, 192-201. Elsevier Limited
Barnard, M, Quanson, J L, Mostaghel, E, Pretorius, E, Snoep, J L & Storbeck, K H 2018, ' 11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3) : Implications for castration resistant prostate cancer ', Journal of Steroid Biochemistry and Molecular Biology, vol. 183, pp. 192-201 . https://doi.org/10.1016/j.jsbmb.2018.06.013
The progression of castration resistant prostate cancer (CRPC) is driven by the intratumoral conversion of adrenal androgen precursors to potent androgens. The expression of aldo-keto reductase 1C3 (AKR1C3), which catalyses the reduction of weak andr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef2ccbf0104b2a854dcbfbb102fe8b4
https://research.vu.nl/en/publications/992c3306-8364-41ac-8e30-5d29ce85b064
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3
The utility of ultra-high performance supercritical fluid chromatography-tandem mass spectrometry (UHPSFC-MS/MS) for clinically relevant steroid analysis
Autor: Karl-Heinz, Storbeck, Lorna, Gilligan, Carl, Jenkinson, Elizabeth S, Baranowski, Jonathan L, Quanson, Wiebke, Arlt, Angela E, Taylor
Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1085
Liquid chromatography tandem mass spectrometry (LC-MS/MS) assays are considered the reference standard for serum steroid hormone analyses, while full urinary steroid profiles are only achievable by gas chromatography (GC-MS). Both LC-MS/MS and GC-MS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d230dc9d4cef6f09ef2d9601a227e162
https://pubmed.ncbi.nlm.nih.gov/29627638
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4
Genetic Disruption of 21-Hydroxylase in Zebrafish Causes Interrenal Hyperplasia
Autor: Helen, Eachus, Andreas, Zaucker, James A, Oakes, Aliesha, Griffin, Meltem, Weger, Tülay, Güran, Angela, Taylor, Abigail, Harris, Andy, Greenfield, Jonathan L, Quanson, Karl-Heinz, Storbeck, Vincent T, Cunliffe, Ferenc, Müller, Nils, Krone
Publikováno v: Endocrinology
Congenital adrenal hyperplasia is a group of common inherited disorders leading to glucocorticoid deficiency. Most cases are caused by 21-hydroxylase deficiency (21OHD). The systemic consequences of imbalanced steroid hormone biosynthesis due to seve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30bdc64aabec5c3f8fdb083baaf8846f
https://pubmed.ncbi.nlm.nih.gov/28938470
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5
11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome
Autor: Michael W, O'Reilly, Punith, Kempegowda, Carl, Jenkinson, Angela E, Taylor, Jonathan L, Quanson, Karl-Heinz, Storbeck, Wiebke, Arlt
Publikováno v: The Journal of Clinical Endocrinology and Metabolism
Context: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to andro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::349ca7db9d8cf885ac999ef33776b0a7
https://pubmed.ncbi.nlm.nih.gov/27901631
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6
High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chromatography tandem mass spectrometry
Autor: Marietjie Stander, Elzette Pretorius, Jonathan L. Quanson, Carl Jenkinson, Angela E Taylor, Karl-Heinz Storbeck
Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1031
11-Oxygenated steroids such as 11-ketotestosterone and 11-ketodihydrotestosterone have recently been shown to play a putative role in the development and progression of castration resistant prostate cancer. In this study we report on the development
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5954151d6705b348932bc05439d3e6b
https://pubmed.ncbi.nlm.nih.gov/27479683
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8
11-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored
Autor: Elzette Pretorius, Donita Africander, Jonathan L. Quanson, Maré Vlok, Meghan S. Perkins, Karl-Heinz Storbeck
Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159867 (2016)
PLoS ONE
Dihydrotestosterone (DHT) is regarded as the most potent natural androgen and is implicated in the development and progression of castration resistant prostate cancer (CRPC). Under castrate conditions, DHT is produced from the metabolism of the adren
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7260026559a4e34671c6e949ae802be9
http://europepmc.org/articles/PMC4956299?pdf=render
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9
11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione
Autor: Amanda C. Swart, Pieter Swart, Karl-Heinz Storbeck, Liezl M. Bloem, Lindie Schloms, Therina du Toit, William E. Rainey, Jonathan L. Quanson
Publikováno v: The Journal of steroid biochemistry and molecular biology. 138
11β-Hydroxyandrostenedione (11OHA4), which is unique to the adrenal, was first isolated from human adrenal tissue in the fifties. It was later shown in the sixties that 11β-hydroxytestosterone (11OHT) was also produced by the human adrenal. Attenti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937f28eb5d659a684bcf6803b245a0ac
https://pubmed.ncbi.nlm.nih.gov/23685396
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