Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jonathan L, Koff"'
Autor:
Silvia Würstle, Alina Lee, Kaitlyn E. Kortright, Franziska Winzig, William An, Gail L. Stanley, Govindarajan Rajagopalan, Zach Harris, Ying Sun, Buqu Hu, Michael Blazanin, Maryam Hajfathalian, Paul L. Bollyky, Paul E. Turner, Jonathan L. Koff, Benjamin K. Chan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked the centennial of Felix d’Hérelle’s first publication on the clinical applications of phages.
Externí odkaz:
https://doaj.org/article/41cdfd5460a14d8d9cd220874c8a6c29
Autor:
Paula F Zamora, Thomas G Reidy, Catherine R Armbruster, Ming Sun, Daria Van Tyne, Paul E Turner, Jonathan L Koff, Jennifer M Bomberger
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002566 (2024)
Phage therapy is a therapeutic approach to treat multidrug-resistant (MDR) infections that employs lytic bacteriophages (phages) to eliminate bacteria. Despite the abundant evidence for its success as an antimicrobial in Eastern Europe, there is scar
Externí odkaz:
https://doaj.org/article/6a64dc52ab974e2cb54129ada93e708c
Autor:
Michael John Patton, Carlos J. Orihuela, Kevin S. Harrod, Mohammad A. N. Bhuiyan, Paari Dominic, Christopher G. Kevil, Daniel Fort, Vincent X. Liu, Maha Farhat, Jonathan L. Koff, Charitharth V. Lal, Anuj Gaggar, Robert P. Richter, Nathaniel Erdmann, Matthew Might, Amit Gaggar
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver of mortality; however, these reports have not been valida
Externí odkaz:
https://doaj.org/article/08100dfe0b7b44c1ad101bf1bafeb813
Autor:
Andrea Hahn MD, MS, Iman Sami MD, Hollis Chaney MD, Anastassios C. Koumbourlis MD, MPH, Coralee Del Valle Mojica MD, MPH, Claire Cochrane BA, Benjamin K. Chan PhD, Jonathan L. Koff MD
Publikováno v:
Journal of Investigative Medicine High Impact Case Reports, Vol 11 (2023)
Cystic fibrosis (CF) is an important monogenic disease that affects more than 70 000 people worldwide. Defects of the CF transmembrane conductance regulator gene lead to dehydrated viscous secretions that result in chronic bacterial colonization. Thi
Externí odkaz:
https://doaj.org/article/7d520f4dab4749968edab62c0eba4335
Autor:
Carolyn S Calfee, Michael A Matthay, Paul Henderson, Martin Eklund, Laura J Esserman, Chirag Patel, Angela Haczku, Michelle Jung, Tony Oliver, Alessio Crippa, Andrea Discacciati, Kathleen D Liu, Ellen L Burnham, Nuala J Meyer, Fady A Youssef, Derek W Russell, Julie Lang, Kevin W Gibbs, Daniel C Files, Sheetal Gandotra, Purnema Madahar, Nathan K Cobb, Timothy E Albertson, Rajiv Sonti, John P Reilly, Alejandra Jauregui, Iván García, Luis E Huerta, Daniel Clark Files, Neil R Aggarwal, Adam L Asare, Jeremy R Beitler, Paul A Berger, George Cimino, Melissa H Coleman, Paul T Henderson, Caroline A G Ittner, Kashif T Khan, Jonathan L Koff, Mary LaRose, Joe Levitt, Ruixiao Lu, Jeffrey D McKeehan, Karl W Thomas, Aaron M Mittel, Albert F Yen, Alexis E Suarez, Alexis L Serra, Alpesh N Amin, Amanda Rosen, Amy L Dzierba, Anna D Barker, Ariel R Weisman, Brian M Daniel, Brian M Morrissey, Caroline AG Ittner, Chayse Jones, Christina Creel-Bulos, Christina M Angelucci, Diana Ng, Fredy Chaparro-Rojas, Gavin H Harris, Harsh V Barot, Heny Su, Jacqueline B Sutter, Jamal Dodin, Jerry S Lee, John Kazianis, Joshua F Detelich, Julie E Lang, Justin Muir, Katarzyna Gosek, Katherine L Nugent, Kimberly Yee, Laura G Rodrigues, Laura R Macias, Lindsey A Orr, Lindsie L Boerger, Lissette Rosario-Remigio, Lucia Kufa, Maged Tanios, Maria B Reyes, Max W Adelman, Maya M Juarez, Michelle Meyers, Mitchell P Sternlieb, Neil Aggarwal, Nilam S Mangalmurti, Patrice Jones, Paul L Saban, Peter S Marshall, Philiip A Robinson, Philip Yang, Rahul Nair, Richard Anthony Lee, Richard G Wunderink, Romina Wahab, Roxana A Lupu, Santhi I Kumar, Sara C Auld, Scott Fields, Se Fum Wong, Skyler J Pearson, Spencer Whealon, Timothy F Obermiller, Anita Darmanian, John Schicchi, Esmeralda Martinez, Farjad Sarafian, Julie Nguyen, Bethany Weiler-Lisowski, Jaime Wyatt, Daniel Blevins, Marylee Melendrez, Brenda Lopez, Hiwet Tzehaie, Omowunmi Amosu, Austin Simonson, Erin Hardy, Brett Lindgren, Gregory Peterfreund, Leigha Landreth, Lisa Parks
Publikováno v:
BMJ Open, Vol 12, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/480eafc2c901401aa40873075dcf1eb8
Autor:
Jessica Geyer, Kristen A. Krupa, Zachary M. Harris, Ying Sun, Lokesh Sharma, Silvia Würstle, Buqu Hu, Gail Stanley, Govindarajan Rajagopalan, Erin Pellot, Jonathan L. Koff, Jayne B. Robinson
Publikováno v:
Antibiotics, Vol 12, Iss 4, p 735 (2023)
Pseudomonas aeruginosa (PsA) is an opportunistic bacterial pathogen that causes life-threatening infections in individuals with compromised immune systems and exacerbates health concerns for those with cystic fibrosis (CF). PsA rapidly develops antib
Externí odkaz:
https://doaj.org/article/86542ffb76884897a7d2ad93480d244d
Publikováno v:
Clinics in Chest Medicine. 43:667-676
Patients with cystic fibrosis (CF) often develop respiratory tract infections with pathogenic multidrug-resistant organisms (MDROs) such as methicillin-resistant Staphylococcus aureus, and a variety of gram-negative organisms that include Pseudomonas
Autor:
Shiv D. Kale, Brittney N. Mehrkens, Molly M. Stegman, Bridget Kastelberg, Henry Carnes, Rachel J. McNeill, Amy Rizzo, Saikumar V. Karyala, Sheryl Coutermarsh-Ott, Jackie A. Fretz, Ying Sun, Jonathan L. Koff, Govindarajan Rajagopalan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) and To
Externí odkaz:
https://doaj.org/article/db5e763e25e14c4ea4bc738c8a6a86b9
Autor:
Dinesh Babu Uthaya Kumar, Efthymios Motakis, Marina Yurieva, Vivek Kohar, Jan Martinek, Te-Chia Wu, Johad Khoury, Jessica Grassmann, Mingyang Lu, Karolina Palucka, Naftali Kaminski, Jonathan L. Koff, Adam Williams
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Although epithelial-mesenchymal transition (EMT) is a common feature of fibrotic lung disease, its role in fibrogenesis is controversial. Recently, aberrant basaloid cells were identified in fibrotic lung tissue as a novel epithelial cell type displa
Autor:
Ying, Sun, Buqu, Hu, Gail, Stanley, Zachary M, Harris, Samir, Gautam, Robert, Homer, Jonathan L, Koff, Govindarajan, Rajagopalan
Publikováno v:
American journal of respiratory cell and molecular biology. 68(1)
The mechanisms by which excessive systemic activation of adaptive T lymphocytes, as in cytokine release syndrome (CRS), leads to innate immune cell-mediated acute lung injury (ALI) or acute respiratory distress syndrome, often in the absence of any i