Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jonathan K. M. Lim"'
Autor:
Jonathan K. M. Lim, Arash Samiei, Alberto Delaidelli, Jessica Oliveira de Santis, Vanessa Brinkmann, Christopher J. Carnie, Daniel Radiloff, Laura Hruby, Alisa Kahler, Jordan Cran, Gabriel Leprivier, Poul H. Sorensen
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-10 (2024)
Abstract Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and consequently mRNA translation elongation, in response to hypoxia and nutrient deprivation. EEF2K is als
Externí odkaz:
https://doaj.org/article/6835837b84d7441fa2ee38d01cd997d9
Autor:
Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose starvation. How mTORC1 controls cell viability during glucose
Externí odkaz:
https://doaj.org/article/b77120ef8e324fda80f5122560600dc1
Autor:
Ulvi Ahmadov, Daniel Picard, Jasmin Bartl, Manuela Silginer, Marija Trajkovic-Arsic, Nan Qin, Lena Blümel, Marietta Wolter, Jonathan K. M. Lim, David Pauck, Alina Marie Winkelkotte, Marlen Melcher, Maike Langini, Viktoria Marquardt, Felix Sander, Anja Stefanski, Sascha Steltgens, Christina Hassiepen, Anna Kaufhold, Frauke-Dorothee Meyer, Annette Seibt, Lara Kleinesudeik, Anika Hain, Carsten Münk, Christiane Brigitte Knobbe-Thomsen, Alexander Schramm, Ute Fischer, Gabriel Leprivier, Kai Stühler, Simone Fulda, Jens T. Siveke, Felix Distelmaier, Arndt Borkhardt, Michael Weller, Patrick Roth, Guido Reifenberger, Marc Remke
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Abstract Glioblastoma is the most common malignant primary brain tumor. To date, clinically relevant biomarkers are restricted to isocitrate dehydrogenase (IDH) gene 1 or 2 mutations and O6-methylguanine DNA methyltransferase (MGMT) promoter methylat
Externí odkaz:
https://doaj.org/article/7af56daa21a545719f08c431620aa3e9
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 1 (2020)
In our recent study, we demonstrated that oncogenic RAS (rat sarcoma)-mediated transformation and tumorigenesis are supported by transcriptional induction of a crucial antioxidant component, SLC7A11 (solute carrier family 7 member 11), otherwise know
Externí odkaz:
https://doaj.org/article/a60ab5753a35473a8cc74063d0e535c3
Autor:
Jonathan K. M. Lim, Gabriel Leprivier
Publikováno v:
Cell Death and Disease, Vol 10, Iss 12, Pp 1-9 (2019)
The RAS family of proto-oncogenes comprises HRAS, KRAS, and NRAS, which are among the most mutated genes in human cancers. The RAS family genes encode small GTPases that coordinate key signaling pathways in response to growth factors. Mutations in RA
Autor:
Amy Li, Anna Prudova, Amal El-Naggar, Hongwei Cheng, Dimiter S. Dimitrov, Jian-Zhong He, Colin A. Hammond, Seth J. Parker, Rimas J. Orentas, Taras Shyp, Renata Scopim-Ribeiro, Xiaojun Li, Olivier Delattre, Christopher S. Hughes, Alberto Delaidelli, Mads Daugaard, Sonia H.Y. Kung, Htoo Zarni Oo, Jonathan K M Lim, Wei Li, Poul H. Sorensen, Hai-Feng Zhang, Anne-Chloe Dhez, Michael M. Lizardo, Shane Colborne, Anne Steino, Didier Surdez, Sofya Langman, Ramon I. Klein Geltink, Gregg B. Morin, Maj Sofie Ørum-Madsen, Li-Yan Xu, Gian Luca Negri
Publikováno v:
Cancer discovery. 11(11)
Cancer cells must overcome anoikis (detachment-induced death) to successfully metastasize. Using proteomic screens, we found that distinct oncoproteins upregulate IL1 receptor accessory protein (IL1RAP) to suppress anoikis. IL1RAP is directly induced
Autor:
John M. Maris, Christopher J. Carnie, Asad Jan, Brandon Jansonius, Marc Remke, Poul H. Sorensen, Htoo Zarni Oo, Debjit Khan, Gian Luca Negri, Jonathan K M Lim, Alberto Delaidelli, Gabriel Leprivier, Amal El-Naggar
Publikováno v:
Cell Death & Differentiation. 24:1564-1576
MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN amplification in childhood neuroblastoma (NB) is associated with aggressive disease and high mortality. Novel and effective therape
Autor:
Daniel Hein, David Pauck, Marc Remke, Gabriel Leprivier, Thorsten Rosenbaum, Heinz Ahlert, Nan Qin, Cyrill Schipp, Arndt Borkhardt, Ute Fischer, Bianca Killing, Lisa Maria Kuhn, Jonathan K M Lim, Sanil Bhatia, Vera H Jepsen, Kai Völtzke, Jasmin Bartl, Viktoria Marquardt
Publikováno v:
Blood. 134:4651-4651
Juvenile myelomonocytic leukemia (JMML) is a chronic, poor prognostic myeloid neoplasm of childhood that is characterized by malignant expansion of monocytic cells. Chemo- and radiotherapy are not effective in JMML, therefore allogeneic hematopoietic
Autor:
Brandon Jansonius, Stefan M. Pfister, Marc Remke, Gabriel Leprivier, Marcel Kool, Jonathan K M Lim, Michael D. Taylor, Asad Jan, Poul H. Sorensen, John M. Maris, Alberto Delaidelli, Gian Luca Negri
Publikováno v:
Neuro-Oncology. 19:vi199-vi200
BACKGROUND/OBJECTIVES MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN and c-MYC amplification in childhood neuroblastoma (NB) and medulloblastoma (MB) are associated with aggressi