Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Jonathan K Stiles"'
Autor:
Carmen M Dickinson-Copeland, Nana O Wilson, Mingli Liu, Adel Driss, Hassana Salifu, Andrew A Adjei, Michael Wilson, Ben Gyan, Daniel Oduro, Kingsley Badu, Felix Botchway, Winston Anderson, Vincent Bond, Methode Bacanamwo, Shailesh Singh, Jonathan K Stiles
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147460 (2016)
Externí odkaz:
https://doaj.org/article/628357b27c434f08ae3f41f1b9e051d6
Autor:
Carmen M Dickinson-Copeland, Nana O Wilson, Mingli Liu, Adel Driss, Hassana Salifu, Andrew A Adjei, Michael Wilson, Ben Gyan, Daniel Oduro, Kingsley Badu, Felix Botchway, Winston Anderson, Vincent Bond, Methode Bacanamwo, Shailesh Singh, Jonathan K Stiles
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142328 (2015)
Plasmodium falciparum infection can cause microvascular dysfunction, cerebral encephalopathy and death if untreated. We have previously shown that high concentrations of free heme, and C-X-C motif chemokine 10 (CXCL10) in sera of malaria patients ind
Externí odkaz:
https://doaj.org/article/191a47eed44e4d2d90f579fb5876dcbe
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71366 (2013)
We have previously reported that free Heme generated during experimental cerebral malaria (ECM) in mice, is central to the pathogenesis of fatal ECM. Heme-induced up-regulation of STAT3 and CXCL10 promotes whereas up-regulation of HO-1 prevents brain
Externí odkaz:
https://doaj.org/article/fbc9ced1353b4a1e976fbe64e3aa249c
Autor:
Nana O Wilson, Wesley Solomon, Leonard Anderson, John Patrickson, Sidney Pitts, Vincent Bond, Mingli Liu, Jonathan K Stiles
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60898 (2013)
Despite appropriate anti-malarial treatment, cerebral malaria (CM)-associated mortalities remain as high as 30%. Thus, adjunctive therapies are urgently needed to prevent or reduce such mortalities. Overproduction of CXCL10 in a subset of CM patients
Externí odkaz:
https://doaj.org/article/fa803c7bad4c4ab097f212accb3c6c01
Autor:
Mingli Liu, Audu S Amodu, Sidney Pitts, John Patrickson, Jacqueline M Hibbert, Monica Battle, Solomon F Ofori-Acquah, Jonathan K Stiles
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34280 (2012)
The mortality of severe malaria [cerebral malaria (CM), severe malaria anemia (SMA), acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)] remains high despite the availability associated with adequate treatments. Recent studies in
Externí odkaz:
https://doaj.org/article/e3865704cbd143519f8ed50b5fa40af7
Autor:
Alaijah Bashi, Cecilia Lekpor, Joshua L. Hood, Winston E. Thompson, Jonathan K. Stiles, Adel Driss
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16934 (2023)
Hemolytic disorders, like malaria and sickle cell disease (SCD), are responsible for significant mortality and morbidity rates globally, specifically in the Americas and Africa. In both malaria and SCD, red blood cell hemolysis leads to the release o
Externí odkaz:
https://doaj.org/article/7d0edafd018341daa1e9c8f406d874f9
Autor:
Justin J. Thomas, Keri Oxendine Harp, Alaijah Bashi, Joshua L. Hood, Felix Botchway, Michael D. Wilson, Winston E. Thompson, Jonathan K. Stiles, Adel Driss
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Hemolysis is associated with many pathologies, including trauma, sepsis, hemorrhagic stroke, malaria, and genetic disorders such as sickle cell disease (SCD). When hemolysis occurs, free-heme drives vascular inflammation, resulting in oxidative tissu
Externí odkaz:
https://doaj.org/article/e8c37e4f126b4229a63da5b737918a56
Autor:
Adriana Harbuzariu, Annette Nti, Keri Oxendine Harp, Juan C. Cespedes, Adel Driss, Jonathan K. Stiles
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104407- (2022)
Summary: Human cerebral malaria (HCM) is a severe complication of Plasmodium falciparum (P.f.) infection that is characterized by capillary occlusions, rupture of the blood-brain barrier (BBB), perivascular cellular injury, and brain swelling. P.f.hi
Externí odkaz:
https://doaj.org/article/614beb3c118f4e97a27a715fe28270a5
Autor:
Keri Oxendine Harp, Alaijah Bashi, Felix Botchway, Daniel Addo-Gyan, Mark Tetteh-Tsifoanya, Amanda Lamptey, Georgina Djameh, Shareen A. Iqbal, Cecilia Lekpor, Saswati Banerjee, Michael D. Wilson, Yvonne Dei-Adomakoh, Andrew A. Adjei, Jonathan K. Stiles, Adel Driss
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7546 (2023)
Malaria affects a significant portion of the global population, with 247 million cases in 2021, primarily in Africa. However, certain hemoglobinopathies, such as sickle cell trait (SCT), have been linked to lower mortality rates in malaria patients.
Externí odkaz:
https://doaj.org/article/b1a1e13948c64533b83a165c0fcebdc8
Autor:
Keri Oxendine Harp, Felix Botchway, Yvonne Dei-Adomakoh, Michael D. Wilson, Mohamed Mubasher, Andrew A. Adjei, Winston E. Thompson, Jonathan K. Stiles, Adel Driss
Publikováno v:
EClinicalMedicine, Vol 39, Iss , Pp 101045- (2021)
Background: Sickle cell anemia (SCA) is a severe monogenic disorder, caused by single nucleotide mutations in the hemoglobin (Hb) gene, that is prevalent in malaria endemic regions of the world. Sickle cell trait (SCT) individuals carry only one of t
Externí odkaz:
https://doaj.org/article/4a6811c384ed4a8c988f1a1a159402f8