Transplanted spleen stromal cells with osteogenic potential support ectopic myelopoiesis.

Autor: Helen C O'Neill, Hong K Lim, Pravin Periasamy, Lavanya Kumarappan, Jonathan K H Tan, Terence J O'Neill

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223416 (2019)

Spleen stromal lines which support in vitro hematopoiesis are investigated for their lineage origin and hematopoietic support function in vivo. Marker expression and gene profiling identify a lineage relationship with mesenchymal stem cells and periv

Externí odkaz: https://doaj.org/article/d162046c4b0944c79fca7dfde01cda89

Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type

Autor: Helen C. O'Neill, Kristin L. Griffiths, Pravin Periasamy, Rebecca A. Hinton, Ying-Ying Hey, Sawang Petvises, Jonathan K. H. Tan

Publikováno v: Stem Cells International, Vol 2011 (2011)

While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvir

Externí odkaz: https://doaj.org/article/6b22e2df20b5463eb11176df2955f6cd

Origin and Immunological Functions of Spleen Stromal Cells

Autor: Andrea Brendolan, Jonathan K. H. Tan, Takeshi Watanabe, Rachel Golub

Publikováno v: Trends in Immunology
Trends in Immunology, 2018, ⟨10.1016/j.it.2018.02.007⟩
Trends in Immunology, Elsevier, 2018, ⟨10.1016/j.it.2018.02.007⟩

International audience; The mammalian spleen is a peripheral lymphoid organ that plays a central role in host defense. Consequently, the lack of spleen is often associated with immunodeficiency and increased risk of overwhelming infections. Growing e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f0888c47ceaed211e675924c92ae68
https://hal-pasteur.archives-ouvertes.fr/pasteur-01768627

Characterization of the effect of LPS on dendritic cell subset discrimination in spleen

Autor: Jonathan K. H. Tan, Helen C. O'Neill, Kristin L. Griffiths

Publikováno v: Journal of Cellular and Molecular Medicine

The Gram-negative bacterial endotoxin lipopolysaccharide (LPS) is a potent inflammatory mediator and a leading cause of bacterial sepsis. While LPS is known to activate antigen-presenting cells, here we find that LPS down-regulates expression of CD11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f18322548f3294e7e5b0fab76969c94
https://doi.org/10.1111/jcmm.12332

3180 – INVESTIGATING IRRADIATION DAMAGE TO HAEMATOPOIETIC NICHES IN THE SPLEEN

Autor: Jonathan K. H. Tan, Helen C. O'Neill, Christie Short

Publikováno v: Experimental Hematology. 76:e5

Haematopoietic stem cell transplantation (HSCT) is used to treat patients with blood disorders such as leukaemia. Intravenous HSCT allows cells to home to the bone marrow niche and initiate long-term haematopoietic reconstitution. However, HSC can al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99dd68467222baee4339efc81b1ee379
https://doi.org/10.1016/j.exphem.2019.09.018