Výsledky vyhledávání - "Jonathan J. Platt"

Akademický článek

Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT)

Publikováno v: Radiation Oncology, Vol 16, Iss 1, Pp 1-9 (2021)

Abstract Background Advances in multi-modality treatment of locally advanced rectal cancer (LARC) have resulted in low local recurrence rates, but around 30% of patients will still die from distant metastatic disease. In parallel, there is increasing

Externí odkaz: https://doaj.org/article/868a94dd8de84d4ca5757841bb549fda

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Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT)

Publikováno v: Radiation Oncology (London, England)
Radiation Oncology, Vol 16, Iss 1, Pp 1-9 (2021)

Background Advances in multi-modality treatment of locally advanced rectal cancer (LARC) have resulted in low local recurrence rates, but around 30% of patients will still die from distant metastatic disease. In parallel, there is increasing recognit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93506228ef0a6aae916b8da3f0157c6b
http://europepmc.org/articles/PMC8393812

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The anti-tumour effect of CD8+ infiltration is associated with Human Leukocyte Antigen Class I expression and tumour proliferation in colorectal cancer

Autor: Jonathan J Platt, Colin H. Richards, Joanne Edwards, Clare Orange, Lindsay Bennett, Paul G. Horgan, Arfon Powell, Donald C. McMillan

PurposeThe host inflammatory response is an important determinant of cancer outcome, however, the factor/s that regulate this response remains unclear. We aimed to determine if Human Leukocyte Antigen (HLA) class I and tumour cell proliferation are a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb5280a4a9e15a46275caf352c65314

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The Impact of Perioperative Risk, Tumor Pathology and Surgical Complications on Disease Recurrence Following Potentially Curative Resection of Colorectal Cancer

Autor: Donald C. McMillan, Ruth F. McKee, Jonathan J. Platt, Colin H. Richards, Paul G. Horgan, John H. Anderson

Publikováno v: Annals of Surgery. 254:83-89

Objective The objective of the study was to identify determinants of disease recurrence after potentially curative resection of colorectal cancer. Summary background data The identification of patients at increased risk of disease recurrence is curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380b42ebc02287fdcf153a2efa2e7192
https://doi.org/10.1097/sla.0b013e31821fd469

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The impact of open versus laparoscopic resection for colon cancer on C-reactive protein concentrations as a predictor of postoperative infective complications

Autor: Paul G. Horgan, Donald C. McMillan, Michelle L. Ramanathan, Jonathan J. Platt, Graham MacKay

Publikováno v: Annals of surgical oncology. 22(3)

There is increasing evidence that C-reactive protein is a useful negative predictor of infective complications and anastomotic leak following surgery for colorectal cancer. In particular, C-reactive protein concentrations on postoperative days 3 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8eaea53a5019cc51417c76c300ce878
https://pubmed.ncbi.nlm.nih.gov/25201503

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Impact of day 2 C-reactive protein on day 3 and 4 thresholds associated with infective complications following curative surgery for colorectal cancer

Autor: Graham MacKay, Donald C. McMillan, Jonathan J. Platt, Paul G. Horgan, Michelle L. Ramanathan

Publikováno v: World journal of surgery. 37(11)

The postoperative systemic inflammatory response, as evidenced by C-reactive protein (CRP) on days 3 and 4, has been reported to be associated with the development of infective complications following surgery for colorectal cancer. However, patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a28d519116ada08ee57a05625305bfb4
https://pubmed.ncbi.nlm.nih.gov/23942534

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C-reactive protein as a predictor of postoperative infective complications after curative resection in patients with colorectal cancer

Autor: Jonathan J. Platt, Donald C. McMillan, Ruth F. McKee, John H. Anderson, Paul G. Horgan, Robin A. Crosbie, Michelle L. Ramanathan

Publikováno v: Annals of surgical oncology. 19(13)

Infective complications particularly in the form of surgical site infections including anastomotic leak represent a serious morbidity after colorectal cancer surgery. Systemic inflammation markers, including C-reactive protein (CRP) and white cell co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3f3b6eac677b4119380bb3cedff2d6
https://pubmed.ncbi.nlm.nih.gov/22805866

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Relationship between preoperative comorbidity, systemic inflammatory response, and survival in patients undergoing curative resection for colorectal cancer

Autor: Jonathan J. Platt, John Kinsella, Campbell S.D. Roxburgh, Donald C. McMillan, E F Leitch, Paul G. Horgan

Publikováno v: Annals of surgical oncology. 18(4)

Besides tumor characteristics, colorectal cancer (CRC) outcomes are also determined by host factors, in particular the systemic inflammatory response. The basis of this relationship with survival is not known; however, systemic inflammation may refle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8143d554cde710ab5584402da474ae66
https://pubmed.ncbi.nlm.nih.gov/21042941

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