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of 29
pro vyhledávání: '"Jonathan J. Morgan"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Deletions of chromosome 1p (del(1p)) are a recurrent genomic aberration associated with poor outcome in Multiple myeloma (MM.) TRIM33, an E3 ligase and transcriptional co-repressor, is located within a commonly deleted region at 1p13.2. TRIM
Externí odkaz:
https://doaj.org/article/43685fcf2e784080aa0b53d8bebdb850
Publikováno v:
Clinical and Translational Discovery, Vol 3, Iss 2, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/5c27637cdcc84e44bf6c973e6f29848d
Autor:
Jonathan J. Morgan, Lisa J. Crawford
Publikováno v:
Cancers, Vol 13, Iss 9, p 2235 (2021)
Faithful DNA replication during cellular division is essential to maintain genome stability and cells have developed a sophisticated network of regulatory systems to ensure its integrity. Disruption of these control mechanisms can lead to loss of gen
Externí odkaz:
https://doaj.org/article/1e2730383b254c4993ced7ff70b729a8
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 702 (2019)
The bone marrow (BM) microenvironment plays an important role in supporting proliferation, survival and drug resistance of Multiple Myeloma (MM) cells. MM cells adhere to bone marrow stromal cells leading to the activation of tumour-promoting signali
Externí odkaz:
https://doaj.org/article/662c0d5d483b42b689f40b278b1e05f8
Autor:
Deirdra Venney, Graeme M Greenfield, Lauren V Cairns, Paul Strain, Áine E McGill, Jonathan J Morgan, Róisín M McAvera, Fatemeh Mirzadeh, Yaser Atlasi, Adone Mohd-Sarip, Ken I Mills
Publikováno v:
Blood. 140:8702-8703
Autor:
Michelle A. Lawson, Jennifer M. Down, Lisa J. Crawford, Dharminder Chauhan, Andrew D Chantry, Claudia Hamilton, Jonathan J. Morgan, Treen C. M. Morris, Krishnaraj Rajalingam, Alexandra E. Irvine, Roisin McAvera, Aswini Krishnan, David Campbell
Publikováno v:
Oncogene
Crawford, L J, Campbell, D C, Morgan, J J, Lawson, M A, Down, J M, Chauhan, D, McAvera, R M, Morris, T C, Hamilton, C, Krishnan, A, Rajalingam, K, Chantry, A D & Irvine, A E 2020, ' The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in Multiple Myeloma ', Oncogene, vol. 39, pp. 5001–5014 . https://doi.org/10.1038/s41388-020-1345-x
Crawford, L J, Campbell, D C, Morgan, J J, Lawson, M A, Down, J M, Chauhan, D, McAvera, R M, Morris, T C, Hamilton, C, Krishnan, A, Rajalingam, K, Chantry, A D & Irvine, A E 2020, ' The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in Multiple Myeloma ', Oncogene, vol. 39, pp. 5001–5014 . https://doi.org/10.1038/s41388-020-1345-x
Proteasome inhibitors have provided a significant advance in the treatment of multiple myeloma (MM). Consequently, there is increasing interest in developing strategies to target E3 ligases, de-ubiquitinases, and/or ubiquitin receptors within the ubi
Autor:
Lisa J. Crawford, Jonathan J. Morgan
Publikováno v:
Cancers, Vol 13, Iss 2235, p 2235 (2021)
Morgan, J J & Crawford, L J 2021, ' The Ubiquitin Proteasome System in Genome Stability and Cancer ', Cancers, vol. 13, no. 9, pp. e2235 . https://doi.org/10.3390/cancers13092235
Cancers
Morgan, J J & Crawford, L J 2021, ' The Ubiquitin Proteasome System in Genome Stability and Cancer ', Cancers, vol. 13, no. 9, pp. e2235 . https://doi.org/10.3390/cancers13092235
Cancers
Simple Summary Genomic instability is a major driving force of tumour development and evolution. Cells have developed sophisticated regulatory systems to preserve the stability of the genome and defects in these mechanisms can lead to the acquisition
Publikováno v:
Blood. 138:1570-1570
Introduction Chromosomal instability is a hallmark of Multiple Myeloma (MM), with most patients displaying cytogenetic abnormalities which can arise due to DNA damage response (DDR) defects. TRIM33 is an E3 ligase and transcriptional co-repressor loc
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S68
Background Chromosomal instability is a hallmark of Multiple Myeloma (MM) with most patients displaying cytogenetic abnormalities which can often act as prognostic indicators. Such abnormalities can arise due to defects in the DNA Damage Response (DD
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:S69