Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jonathan J. Lyon"'
Autor:
Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i
Externí odkaz:
https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf
Autor:
Charlotte A. Hoogstraten, Jonathan J. Lyon, Jan A.M. Smeitink, Frans G.M. Russel, Tom J.J. Schirris
Publikováno v:
Pharmacological Reviews, 75, 463-486
Pharmacological Reviews, 75, 3, pp. 463-486
Pharmacological Reviews, 75, 3, pp. 463-486
Contains fulltext : 292356.pdf (Publisher’s version ) (Open Access) An increasing number of commonly prescribed drugs are known to interfere with mitochondrial function, which is associated with almost half of all Food and Drug Administration black
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac64c44746b5eee4dd15cba7968a76b
http://hdl.handle.net/2066/292356
http://hdl.handle.net/2066/292356
Autor:
Brian Walitt, Komudi Singh, Samuel R. LaMunion, Mark Hallett, Steve Jacobson, Kong Chen, Yoshimi Enose-Akahata, Richard Apps, Jennifer J. Barb, Patrick Bedard, Robert J. Brychta, Ashura Williams Buckley, Peter D. Burbelo, Brice Calco, Brianna Cathay, Li Chen, Snigdha Chigurupati, Jinguo Chen, Foo Cheung, Lisa M. K. Chin, Benjamin W. Coleman, Amber B. Courville, Madeleine S. Deming, Bart Drinkard, Li Rebekah Feng, Luigi Ferrucci, Scott A. Gabel, Angelique Gavin, David S. Goldstein, Shahin Hassanzadeh, Sean C. Horan, Silvina G. Horovitz, Kory R. Johnson, Anita Jones Govan, Kristine M. Knutson, Joy D. Kreskow, Mark Levin, Jonathan J. Lyons, Nicholas Madian, Nasir Malik, Andrew L. Mammen, John A. McCulloch, Patrick M. McGurrin, Joshua D. Milner, Ruin Moaddel, Geoffrey A. Mueller, Amrita Mukherjee, Sandra Muñoz-Braceras, Gina Norato, Katherine Pak, Iago Pinal-Fernandez, Traian Popa, Lauren B. Reoma, Michael N. Sack, Farinaz Safavi, Leorey N. Saligan, Brian A. Sellers, Stephen Sinclair, Bryan Smith, Joseph Snow, Stacey Solin, Barbara J. Stussman, Giorgio Trinchieri, Sara A. Turner, C. Stephenie Vetter, Felipe Vial, Carlotta Vizioli, Ashley Williams, Shanna B. Yang, Center for Human Immunology, Autoimmunity, and Inflammation (CHI) Consortium, Avindra Nath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used
Externí odkaz:
https://doaj.org/article/a14b918b7de649e6975c4ac14fdd7aa8
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Hereditary α tryptasemia (HαT) is an autosomal dominant trait characterized by increased TPSAB1 copy number (CN) encoding α-tryptase. The determination of HαT is being discussed as an important biomarker to be included in risk assessment
Externí odkaz:
https://doaj.org/article/733cbf0add714b448e0c4caa7df11628
Autor:
Jonathan J. Lyon, John Kenny, Amy L. Ball, Amy E. Chadwick, Lucille Rainbow, Xuan Liu, Katarzyna M Bloch, Richard Gregory, Ana Alfirevic
Publikováno v:
Archives of Toxicology
Mitochondrial DNA (mtDNA) is highly polymorphic and encodes 13 proteins which are critical to the production of ATP via oxidative phosphorylation. As mtDNA is maternally inherited and undergoes negligible recombination, acquired mutations have subdiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ec42d55adae4dd71f89eeb5b719f0f
https://pubmed.ncbi.nlm.nih.gov/33585966
https://pubmed.ncbi.nlm.nih.gov/33585966
Autor:
Alan R. Boobis, Ashley J. Broom, Gino Brunori, Richard A. Peterson, Mitul Gandhi, Ian Francis, Jeffrey L. Ambroso, Jonathan J. Lyon, Angie Burns, James R. Armitage, Timothy W. Gant
Publikováno v:
Toxicology Research. 5:136-150
Relating the in vitro mitochondrial effects of drug candidates to likely in vivo outcomes remains challenging. Better understanding of this relationship, alongside improved methods to assess mitochondrial dysfunction in vivo, would both guide safer d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::069035d487120c4ec64078419d026b4a
https://doi.org/10.1039/c5tx00197h
https://doi.org/10.1039/c5tx00197h
Autor:
Breanna J. Beers, Morgan N. Similuk, Rajarshi Ghosh, Bryce A. Seifert, Leila Jamal, Michael Kamen, Michael R. Setzer, Colleen Jodarski, Rylee Duncan, Devin Hunt, Madison Mixer, Wenjia Cao, Weimin Bi, Daniel Veltri, Eric Karlins, Lingwen Zhang, Zhiwen Li, Andrew J. Oler, Kathleen Jevtich, Yunting Yu, Haley Hullfish, Bibiana Bielekova, Pamela Frischmeyer-Guerrerio, An Dang Do, Laryssa A. Huryn, Kenneth N. Olivier, Helen C. Su, Jonathan J. Lyons, Christa S. Zerbe, V. Koneti Rao, Michael D. Keller, Alexandra F. Freeman, Steven M. Holland, Luis M. Franco, Magdalena A. Walkiewicz, Jia Yan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
PurposeThough copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We sought to determine the diagnostic contribution of CNVs using
Externí odkaz:
https://doaj.org/article/5a9a5d2c1d2843bb9d22ca82e9ec744f
Autor:
Ashley J, Broom, Jeffrey, Ambroso, Gino, Brunori, Angie K, Burns, James R, Armitage, Ian, Francis, Mitul, Gandhi, Richard A, Peterson, Timothy W, Gant, Alan R, Boobis, Jonathan J, Lyon
Publikováno v:
Toxicology Research
Schematic showing the toxicological and adaptive effects of drug-induced respiratory chain inhibition in vivo; also highlighting unanticipated differences from observations made in vitro (in red).
Relating the in vitro mitochondrial effects of d
Relating the in vitro mitochondrial effects of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c217e872badc4521d8351d04b6197d4
https://pubmed.ncbi.nlm.nih.gov/29780577
https://pubmed.ncbi.nlm.nih.gov/29780577
Autor:
Jonathan J. Lyon, Roger J. Watson
Publikováno v:
Differentiation. 59:171-178
The c-myb proto-oncogene encodes a transcription factor that has been implicated in the regulation of haemopoietic cell differentiation and appears also to be required for cell proliferation in a number of different lineages. Typically, transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c331178da638926d8ecef18650e974c
https://doi.org/10.1046/j.1432-0436.1995.5930171.x
https://doi.org/10.1046/j.1432-0436.1995.5930171.x
Autor:
Brian R. Berridge, Yasmina Bauer, Martin Letzkus, Philippe Couttet, Caterina Vacchi-Suzzi, Kevin Gerrish, Jonathan J. Lyon, Sandrine Bongiovanni, Francois Pognan, Olivier Grenet, Martin P. Vidgeon-Hart, Richard S. Paules, Frank Staedtler, Jonathan G. Moggs, Hisham K. Hamadeh
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e40395 (2012)
PLoS ONE, Vol 7, Iss 7, p e40395 (2012)
Anti-cancer therapy based on anthracyclines (DNA intercalating Topoisomerase II inhibitors) is limited by adverse effects of these compounds on the cardiovascular system, ultimately causing heart failure. Despite extensive investigations into the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91657dbcaff190b76c47698e687a601c
http://europepmc.org/articles/PMC3409211
http://europepmc.org/articles/PMC3409211