Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jonathan J. Havel"'
Autor:
Martin G. Dalin, Nora Katabi, Marta Persson, Ken-Wing Lee, Vladimir Makarov, Alexis Desrichard, Logan A. Walsh, Lyndsay West, Zaineb Nadeem, Deepa Ramaswami, Jonathan J. Havel, Fengshen Kuo, Kalyani Chadalavada, Gouri J. Nanjangud, Ian Ganly, Nadeem Riaz, Alan L. Ho, Cristina R. Antonescu, Ronald Ghossein, Göran Stenman, Timothy A. Chan, Luc G. T. Morris
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Myoepithelial carcinoma (MECA) is a rare aggressive salivary gland cancer. Here, the authors analyze the genomic landscape of MECA and identify a high prevalence of oncogenic gene fusions, primarily PLAG1 fusions, highlighting TGFBR3-PLAG1 as a poten
Externí odkaz:
https://doaj.org/article/ac5cf5be332f48df922f9b4c8c1e098f
Autor:
Timothy A. Chan, Jonathan J. Havel, Hui Jiang, Jingming Wang, Xiaoxiao Ma, Chirag Krishna, Erich Sabio, Xiao Zhang
Immune checkpoint blockade (ICB) has improved cancer care, but ICB is only effective in some patients. The molecular mechanisms that influence ICB therapy response are not completely understood. The non-classical MHC class I molecule HLA-E and its mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c53217767b1932e7e67ae1e693c48b4
https://doi.org/10.1158/1541-7786.c.6545250
https://doi.org/10.1158/1541-7786.c.6545250
Autor:
Timothy A. Chan, Jonathan J. Havel, Hui Jiang, Jingming Wang, Xiaoxiao Ma, Chirag Krishna, Erich Sabio, Xiao Zhang
Fig. S1 Amplicon sequencing of the Crispr-cas9 targeting region.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd7c2899b9d4c7436b925187972c8b9
https://doi.org/10.1158/1541-7786.22526928
https://doi.org/10.1158/1541-7786.22526928
Autor:
Jonathan P. Schneck, Timothy A. Chan, Alyssa Kosmides, Jonathan J. Havel, Catherine A. Bessell, John-William Sidhom
S1. In order to set thresholds for motif detection, two variables were optimized on a Naïve Adult B6 CD8 Repertoire (taken from Adaptive Biotechnologies ImmunoSeq Sample Data). Motif detection was completed across a range of phylogenetic distances a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f7148f588657cc79934b8b2e0d7a5a
https://doi.org/10.1158/2326-6066.22539614.v1
https://doi.org/10.1158/2326-6066.22539614.v1
Autor:
Timothy A. Chan, Jonathan J. Havel, Hui Jiang, Jingming Wang, Xiaoxiao Ma, Chirag Krishna, Erich Sabio, Xiao Zhang
Supplemental Figure Legends 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374c361d1df92c2b69906fae93789f99
https://doi.org/10.1158/1541-7786.22526916.v1
https://doi.org/10.1158/1541-7786.22526916.v1
Autor:
Jonathan P. Schneck, Timothy A. Chan, Alyssa Kosmides, Jonathan J. Havel, Catherine A. Bessell, John-William Sidhom
Despite a dramatic increase in T-cell receptor (TCR) sequencing, few approaches biologically parse the data in a fashion that both helps yield new information about immune responses and may guide immunotherapeutic interventions. To address this issue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb69c5a0a85b1c38755bd567b5654da3
https://doi.org/10.1158/2326-6066.c.6549140.v1
https://doi.org/10.1158/2326-6066.c.6549140.v1
Autor:
Leland W.K. Chung, Takeo Nomura, Chia-Yi Chu, Hui-Wen Lue, Wei Ping Qian, Haiyen E. Zhau, Jonathan J. Havel, Wen-Chin Huang
Supplementary Data from β2-Microglobulin Signaling Blockade Inhibited Androgen Receptor Axis and Caused Apoptosis in Human Prostate Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3071ee2da0d5576c820718c912751464
https://doi.org/10.1158/1078-0432.22439868
https://doi.org/10.1158/1078-0432.22439868
Autor:
Leland W.K. Chung, Takeo Nomura, Chia-Yi Chu, Hui-Wen Lue, Wei Ping Qian, Haiyen E. Zhau, Jonathan J. Havel, Wen-Chin Huang
Purpose: β2-Microglobulin (β2M) has been shown to promote osteomimicry and the proliferation of human prostate cancer cells. The objective of this study is to determine the mechanism by which targeting β2M using anti-β2M antibody inhibited growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293f367686014d4ddef01cd889661ded
https://doi.org/10.1158/1078-0432.c.6517272.v1
https://doi.org/10.1158/1078-0432.c.6517272.v1
Autor:
Erich Y. Sabio, Timothy A. Chan, Xiao Zhang, Xiaoxiao Ma, Chirag Krishna, Jingming Wang, Jonathan J. Havel, Hui Jiang
Publikováno v:
Mol Cancer Res
Immune checkpoint blockade (ICB) has improved cancer care, but ICB is only effective in some patients. The molecular mechanisms that influence ICB therapy response are not completely understood. The non-classical MHC class I molecule HLA-E and its mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e505fc539a8141956365d171987334bb
https://doi.org/10.1158/1541-7786.mcr-20-0652
https://doi.org/10.1158/1541-7786.mcr-20-0652
Autor:
Justin Tepe, Alan L. Ho, Robert M. Samstein, Nora Katabi, Fengshen Kuo, Raghvendra M. Srivastava, Marc Cohen, Nadeem Riaz, Kety Huberman, Zaineb Nadeem, S. Ken Tian, Timothy A. Chan, Chirag Krishna, Richard J. Wong, Phaedra Agius, Kanika Arora, Douglas R. Hoen, Katelynd Vanness, Nancy Bouvier, Ronald Ghossein, Rajarsi Mandal, Wei Yang, Martin G. Dalin, Ken-Wing Lee, Vladimir Makarov, Jonathan J. Havel, Diego Chowell, Heather Geiger, Luc G. T. Morris, Leonard H. Wexler, Nicolas Robine, Jennifer S. Sims, Neerav Shukla, Ian Ganly
Publikováno v:
Nature medicine
Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate that gene fusions are a source of immunog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fb59aba3a3e70500a90b06d6273722
https://doi.org/10.1038/s41591-019-0434-2
https://doi.org/10.1038/s41591-019-0434-2