Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE

Autor: Mikel García-Alija, Jonathan J. Du, Izaskun Ordóñez, Asier Diz-Vallenilla, Alicia Moraleda-Montoya, Nazneen Sultana, Chau G. Huynh, Chao Li, Thomas Connor Donahue, Lai-Xi Wang, Beatriz Trastoy, Eric J. Sundberg, Marcelo E. Guerin

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

EndoE is a multi-domain glycoside hydrolase of the human pathogen Enterococcus faecalis. Here, the authors present crystal structures of EndoE and provide biochemical insights into the molecular basis of EndoE’s substrate specificity and catalytic

Externí odkaz: https://doaj.org/article/db42ad5c6c87426d8b470e8e6d00b296

A Guide to In Silico Drug Design

Autor: Yiqun Chang, Bryson A. Hawkins, Jonathan J. Du, Paul W. Groundwater, David E. Hibbs, Felcia Lai

Publikováno v: Pharmaceutics, Vol 15, Iss 1, p 49 (2022)

The drug discovery process is a rocky path that is full of challenges, with the result that very few candidates progress from hit compound to a commercially available product, often due to factors, such as poor binding affinity, off-target effects, o

Externí odkaz: https://doaj.org/article/2a39dc69ec314f6ca945248d1719c722

Mass Spectrometry-Based Methods to Determine the Substrate Specificities and Kinetics of N-Linked Glycan Hydrolysis by Endo-β-N-Acetylglucosaminidases

Autor: Jonathan J. Du, Diego Sastre, Beatriz Trastoy, Blaine Roberts, Daniel Deredge, Erik H. Klontz, Maria W. Flowers, Nazneen Sultana, Marcelo E. Guerin, Eric J. Sundberg

Publikováno v: Methods in Molecular Biology ISBN: 9781071632420

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2732f3689d612d09f7b1df697146e8fb
https://doi.org/10.1007/978-1-0716-3243-7_10

The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification

Autor: Christy El-Khoury, Elissar Mansour, Yori Yuliandra, Felcia Lai, Bryson A. Hawkins, Jonathan J. Du, Eric J. Sundberg, Nicolas Sluis-Cremer, David E. Hibbs, Paul W. Groundwater

Publikováno v: RSC medicinal chemistry. 13(11)

Antibacterial resistance is a prominent issue with monotherapy often leading to treatment failure in serious infections. Many mechanisms can lead to antibacterial resistance including deactivation of antibacterial agents by bacterial enzymes. Enzymat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ddd311445b31a582f98126828293eb
https://pubmed.ncbi.nlm.nih.gov/36439977

An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization

Autor: Bryson A. Hawkins, Jonathan J. Du, Felcia Lai, Stephen A. Stanton, Peter A. Williams, Paul W. Groundwater, James A. Platts, Jacob Overgaard, David E. Hibbs

Publikováno v: Hawkins, B A, Du, J J, Lai, F, Stanton, S A, Williams, P A, Groundwater, P W, Platts, J A, Overgaard, J & Hibbs, D E 2022, ' An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization ', RSC Advances, vol. 12, no. 25, pp. 15670-15684 . https://doi.org/10.1039/d1ra08389a

The pharmaceutical agent theophylline (THEO) is primarily used as a bronchodilator and is commercially available in both tablet and liquid dosage forms. THEO is highly hygroscopic, reducing its stability, overall shelf-life, and therefore usage as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b19c6582be97f23d2ecf1f28e0cd8a6
https://pure.au.dk/portal/da/publications/an-experimental-and-theoretical-charge-density-study-of-theophylline-and-malonic-acid-cocrystallization(607298f6-8643-4416-a8cb-3ef68680452b).html