Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jonathan J. Burbaum"'
Publikováno v:
Current Opinion in Biotechnology. 24(3):369-375
To compare the utility of current and future biofuels and biofuel feedstocks in an objective manner can be extremely challenging. This challenge exists because agricultural data are inherently variable, experimental techniques are crop-dependent, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2165be1e789034bea5aa79c16c23562b
Autor:
Jonathan J. Burbaum, Melanie R. Nelson, Jennifer S. Montimurro, Jeffrey A. Speir, Susan M. Baxter, Jeannine A. Di Gennaro, Jonathan S. Rosenblum, Stacy T. Knutson, Jacquelyn S. Fetrow
Publikováno v:
Molecular & Cellular Proteomics. 3:209-225
An analysis of the structurally and catalytically diverse serine hydrolase protein family in the Saccharomyces cerevisiae proteome was undertaken using two independent but complementary, large-scale approaches. The first approach is based on computat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9896bf6bddc3eb6e1340e811749172f7
https://doi.org/10.1074/mcp.m300082-mcp200
https://doi.org/10.1074/mcp.m300082-mcp200
Autor:
John W. Kozarich, Gregory C. Adam, Jonathan J. Burbaum, Benjamin F. Cravatt, Matthew P. Patricelli
Publikováno v:
Journal of the American Chemical Society. 126:1363-1368
Genome sequencing projects have uncovered many novel enzymes and enzyme classes for which knowledge of active site structure and mechanism is limited. To facilitate mechanistic investigations of the numerous enzymes encoded by prokaryotic and eukaryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f583273a3b01d1f0f49912a93b7c34f4
https://doi.org/10.1021/ja038441g
https://doi.org/10.1021/ja038441g
Publikováno v:
Assay and Drug Development Technologies. 1:137-146
In the latter stages of drug discovery and development, assays that establish drug selectivity and toxicity are important when side effects, which are often due to lack of specificity, determine drug candidate viability. There has been no comprehensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a43f0c992be0b8028f476f70b71389
https://doi.org/10.1089/154065803762851306
https://doi.org/10.1089/154065803762851306
Publikováno v:
PROTEOMICS. 1:1067-1071
The field of biochemistry is currently faced with the enormous challenge of assigning functional significance to more than thirty thousand predicted protein products encoded by the human genome. In order to accomplish this daunting task, methods will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::898bd3ddb25a854a60677fc400015f08
https://doi.org/10.1002/1615-9861(200109)1:9<1067::aid-prot1067>3.0.co
https://doi.org/10.1002/1615-9861(200109)1:9<1067::aid-prot1067>3.0.co
Autor:
David A. Dunn, L. Ozgur, M. Orlowski, Jonathan J. Burbaum, P. McCoy, Maria L. Webb, Kenneth C. Appell, F. Gastgeb
Publikováno v:
SLAS Discovery. 5:177-187
Results of a complete survey of the more than 2-million-member Pharmacopeia compound collection in a 1536-well microvolume screening assay format are reported. A complete technology platform, enabling the performance of ultra-high throughput screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5affd0965cdf1515e013038c1b5e65d3
https://doi.org/10.1177/108705710000500310
https://doi.org/10.1177/108705710000500310
Autor:
Jonathan J. Burbaum
Publikováno v:
Drug Discovery Today. 3:313-322
Miniaturized analytical methods are currently being developed to suit many needs. One area that is evolving with particular speed is HTS for pharmaceutical lead discovery. This review explores the scope and impact of miniaturized methods as applied t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5348ad2985f3bfa68e0675b46f428798
https://doi.org/10.1016/s1359-6446(98)01203-3
https://doi.org/10.1016/s1359-6446(98)01203-3
Autor:
Jonathan J. Burbaum, Nolan H. Sigal
Publikováno v:
Current Opinion in Chemical Biology. 1:72-78
To screen efficiently the millions of compounds that are synthesized using combinatorial and automated methods, dramatically improved assay technologies are currently needed. In 96-well microtiter plates, nonradioactive techniques (primarily fluorime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dbd16470d897d16bc3755e4b383d0e
https://doi.org/10.1016/s1367-5931(97)80111-1
https://doi.org/10.1016/s1367-5931(97)80111-1
Autor:
Alice I. Marcy, Laura Rokosz, William K. Hagmann, Joseph W. Becker, James P. Springer, Melinda G. Axel, Craig K. Esser, Paula M.D. Fitzgerald, Jeffrey D. Hermes, Patricia M. Cameron, Jonathan J. Burbaum
Publikováno v:
Protein Science. 4:1966-1976
The proteolytic enzyme stromelysin-1 is a member of the family of matrix metalloproteinases and is believed to play a role in pathological conditions such as arthritis and tumor invasion. Stromelysin-1 is synthesized as a pro-enzyme that is activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992d974e8c092c7e5bed267afbab6bb2
https://doi.org/10.1002/pro.5560041002
https://doi.org/10.1002/pro.5560041002
Autor:
Lawrence W. Dillard, Daniel Chelsky, Ian R. Henderson, John C. Reader, Ge Li, Michael Ohlmeyer, Nolan H. Sigal, Baldwin John J, Jonathan J. Burbaum, Troy L. Randle
Publikováno v:
Proceedings of the National Academy of Sciences. 92:6027-6031
Very large combinatorial libraries of small molecules on solid supports can now be synthesized and each library element can be identified after synthesis by using chemical tags. These tag-encoded libraries are potentially useful in drug discovery, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f855442c2b2b420692b0849177891223
https://doi.org/10.1073/pnas.92.13.6027
https://doi.org/10.1073/pnas.92.13.6027