Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jonathan J Hulce"'
Autor:
Benjamin F. Cravatt, Jonathan J. Hulce, Daisuke Ogasawara, Taka-Aki Ichu, Alex Reed, Olesya A. Ulanovskaya, Hui Jing
Publikováno v:
Journal of Medicinal Chemistry. 62:1643-1656
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lyso-phosphatidylserine (lyso-PS) and lyso-phosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1e0005d5958520ff1dc6cecd65f01b
https://doi.org/10.1021/acs.jmedchem.8b01958
https://doi.org/10.1021/acs.jmedchem.8b01958
Autor:
Jacqueline R. Benthuysen, Vincent F. Vartabedian, Alex Reed, Hugh Rosen, Benjamin F. Cravatt, Amanda J. Roberts, Daisuke Ogasawara, Olesya A. Ulanovskaya, Hui Jing, Taka-Aki Ichu, Jonathan J. Hulce, John R. Teijaro, Steven D. Brown
Publikováno v:
Nature chemical biology
ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological disease PHARC, and ABHD12(−/−) mice display PHARC-like phenotypes, including hearing loss, al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bc8d244da0bcb266201b21fd3b9fb0
http://europepmc.org/articles/PMC6263940
http://europepmc.org/articles/PMC6263940
Autor:
Anil, Vasudevan, Maria A, Argiriadi, Aleksandra, Baranczak, Michael M, Friedman, Julia, Gavrilyuk, Adrian D, Hobson, Jonathan J, Hulce, Sami, Osman, Noel S, Wilson
Publikováno v:
Progress in medicinal chemistry. 58
Covalent modulation of protein function can have multiple utilities including therapeutics, and probes to interrogate biology. While this field is still viewed with scepticism due to the potential for (idiosyncratic) toxicities, significant strides h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f01848ab660f5c8ddca1f6113bba81d
https://pubmed.ncbi.nlm.nih.gov/30879472
https://pubmed.ncbi.nlm.nih.gov/30879472
Autor:
Julia Gavrilyuk, Wilson Noel S, Jonathan J Hulce, Sami Osman, Maria A. Argiriadi, Anil Vasudevan, Aleksandra Baranczak, Michael Friedman, Adrian D. Hobson
Covalent modulation of protein function can have multiple utilities including therapeutics, and probes to interrogate biology. While this field is still viewed with scepticism due to the potential for (idiosyncratic) toxicities, significant strides h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7503c7128199dd6b6b36ccad1165161
https://doi.org/10.1016/bs.pmch.2018.12.002
https://doi.org/10.1016/bs.pmch.2018.12.002
Autor:
Armand B. Cognetta, Jonathan J. Hulce, Benjamin F. Cravatt, Michael L Martini, Hyeon-Cheol Lee, Micah J. Niphakis
Publikováno v:
Chemistry & Biology. 22:928-937
Serine hydrolase inhibitors, which facilitate enzyme function assignment and are used to treat a range of human disorders, often act by an irreversible mechanism that involves covalent modification of the serine hydrolase catalytic nucleophile. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af327ecacf17d97aafa0060561d9110a
https://doi.org/10.1016/j.chembiol.2015.05.018
https://doi.org/10.1016/j.chembiol.2015.05.018
Autor:
John Charles Kath, Theodore O. Johnson, Landon R. Whitby, Benjamin F. Cravatt, Baoxian Wei, Chu Wang, Mark E. Schnute, Melissa M. Dix, Lee R. Roberts, Laurence O. Whiteley, Adam M. Gilbert, Jonathan J. Hulce, Sherry Niessen, Erik C. Hett, Chris Joslyn, Matthew Merrill Hayward, Bryan R. Lanning, John Douhan
Publikováno v:
Nature chemical biology
Kinases are principal components of signal transduction pathways and the focus of intense basic and drug discovery research. Irreversible inhibitors that covalently modify non-catalytic cysteines in kinase active-sites have emerged as valuable probes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4cc4677878a633174a0e1621180667
http://europepmc.org/articles/PMC4138289
http://europepmc.org/articles/PMC4138289
Autor:
Benjamin F. Cravatt, Micah J. Niphakis, Jonathan J. Hulce, Sarah E. Tully, Armand B. Cognetta
Publikováno v:
Nature methods
Cholesterol is an essential structural component of cellular membranes and serves as a precursor for several classes of signaling molecules. Cholesterol exerts its effects and is, itself, regulated in large part by engagement in specific interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c76e63d3099906ee459077e6af06d22
https://doi.org/10.1038/nmeth.2368
https://doi.org/10.1038/nmeth.2368
Autor:
K. Barry Sharpless, Peter Lee, David E. Mortenson, Gabriel J. Brighty, Enrique Saez, Jonathan J. Hulce, Lars Plate, Yu Liu, Wentao Chen, Andrea Galmozzi, Jeffery W. Kelly, Ian A. Wilson, Jiajia Dong, Suhua Li, Evan T. Powers, Benjamin F. Cravatt
Arylfluorosulfates have appeared only rarely in the literature and have not been explored as probes for covalent conjugation to proteins, possibly because they were assumed to possess high reactivity, as with other sulfur(VI) halides. However, we fin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a14a31224504e20434d176768dde84e
https://europepmc.org/articles/PMC4909538/
https://europepmc.org/articles/PMC4909538/
Autor:
Kenta Masui, Huijun Yang, Shiro Ikegami, Paul S. Mischel, Timothy C. Gahman, Gabrielle L. Cahill, David Jenkins, Oswald Quehenberger, Frank B. Furnari, Gary C. Hon, Benjamin F. Cravatt, Peter Tontonoz, Jonathan J. Hulce, Andrew K. Shiau, Xin Rong, Webster K. Cavenee, Feng Liu, Aaron M. Armando, Kenneth M. Lum, Junfeng Bi, Genaro R. Villa, Cynthia Hong, Timothy F. Cloughesy, Kristen M. Turner, Michael L Martini, Yuchao Gu, Ciro Zanca
Publikováno v:
Cancer cell, vol 30, iss 5
Small-molecule inhibitors targeting growth factor receptors have failed to show efficacy for brain cancers, potentially due to their inability to achieve sufficient drug levels in the CNS. Targeting non-oncogene tumor co-dependencies provides an alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1f63473cbc722c79f0e335f278caa6
https://pubmed.ncbi.nlm.nih.gov/27846382
https://pubmed.ncbi.nlm.nih.gov/27846382
Autor:
Hermann Rohrer, Anthony C. Pappas, John Soltys, Maria-Christina Bravo, Jutta Stubbusch, Leslie Huber, Jonathan J. Hulce, Benjamin Bakondi, Martin Hruska, Rae Nishi
Publikováno v:
The Journal of Comparative Neurology. 518:839-850
Somatostatin and cortistatin are neuromodulators with divergent expression patterns and biological roles. Whereas expression and function of genes encoding somatostatin (PSS1) and the related peptide cortistatin (PSS2) have been studied in detail for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb1f00ab0395f48cc730feee0ed2bc7
https://doi.org/10.1002/cne.22245
https://doi.org/10.1002/cne.22245