Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases

Autor: Beatriz Trastoy, Jonathan J. Du, Javier O. Cifuente, Lorena Rudolph, Mikel García-Alija, Erik H. Klontz, Daniel Deredge, Nazneen Sultana, Chau G. Huynh, Maria W. Flowers, Chao Li, Diego E. Sastre, Lai-Xi Wang, Francisco Corzana, Alvaro Mallagaray, Eric J. Sundberg, Marcelo E. Guerin

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Here, the authors establish the mechanisms of recognition and specific deglycosylation of IgG antibodies by

Externí odkaz: https://doaj.org/article/7aed46f3a16540f68a93f7c72eef2df7

Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides

Autor: Beatriz Trastoy, Jonathan J. Du, Erik H. Klontz, Chao Li, Javier O. Cifuente, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Human gut bacteria depolymerize glycans into their sugar components, which otherwise cannot be processed by their host. Here, the authors characterise the endo-β-N-acetylglucosaminidase EndoBT-3987 from the Gram-negative symbiont Bacteroides thetaio

Externí odkaz: https://doaj.org/article/0967fd4440514038b204e0c6670b530c

Mass Spectrometry-Based Methods to Determine the Substrate Specificities and Kinetics of N-Linked Glycan Hydrolysis by Endo-β-N-Acetylglucosaminidases

Autor: Jonathan J. Du, Diego Sastre, Beatriz Trastoy, Blaine Roberts, Daniel Deredge, Erik H. Klontz, Maria W. Flowers, Nazneen Sultana, Marcelo E. Guerin, Eric J. Sundberg

Publikováno v: Methods in Molecular Biology ISBN: 9781071632420

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2732f3689d612d09f7b1df697146e8fb
https://doi.org/10.1007/978-1-0716-3243-7_10

The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification

Autor: Christy El-Khoury, Elissar Mansour, Yori Yuliandra, Felcia Lai, Bryson A. Hawkins, Jonathan J. Du, Eric J. Sundberg, Nicolas Sluis-Cremer, David E. Hibbs, Paul W. Groundwater

Publikováno v: RSC medicinal chemistry. 13(11)

Antibacterial resistance is a prominent issue with monotherapy often leading to treatment failure in serious infections. Many mechanisms can lead to antibacterial resistance including deactivation of antibacterial agents by bacterial enzymes. Enzymat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ddd311445b31a582f98126828293eb
https://pubmed.ncbi.nlm.nih.gov/36439977

An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization

Autor: Bryson A. Hawkins, Jonathan J. Du, Felcia Lai, Stephen A. Stanton, Peter A. Williams, Paul W. Groundwater, James A. Platts, Jacob Overgaard, David E. Hibbs

Publikováno v: Hawkins, B A, Du, J J, Lai, F, Stanton, S A, Williams, P A, Groundwater, P W, Platts, J A, Overgaard, J & Hibbs, D E 2022, ' An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization ', RSC Advances, vol. 12, no. 25, pp. 15670-15684 . https://doi.org/10.1039/d1ra08389a

The pharmaceutical agent theophylline (THEO) is primarily used as a bronchodilator and is commercially available in both tablet and liquid dosage forms. THEO is highly hygroscopic, reducing its stability, overall shelf-life, and therefore usage as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b19c6582be97f23d2ecf1f28e0cd8a6
https://pure.au.dk/portal/da/publications/an-experimental-and-theoretical-charge-density-study-of-theophylline-and-malonic-acid-cocrystallization(607298f6-8643-4416-a8cb-3ef68680452b).html