Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells

Autor: Jonathan Hollmann, Johanna Brecht, Roman Goetzke, Julia Franzen, Anton Selich, Marco Schmidt, Monika Eipel, Alina Ostrowska, Jan Hapala, Eduardo Fernandez-Rebollo, Gerhard Müller-Newen, Michael Rothe, Thomas Eggermann, Martin Zenke, Wolfgang Wagner

Publikováno v: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2020)

Abstract Background The use of mesenchymal stromal cells (MSCs) for research and clinical application is hampered by cellular heterogeneity and replicative senescence. Generation of MSC-like cells from induced pluripotent stem cells (iPSCs) may circu

Externí odkaz: https://doaj.org/article/df179f3bd39144b6b52fc3d37e4a90fc

Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells

Autor: Matteo Oliverio, Julia Franzen, Jonathan Hollmann, Alina Ostrowska, Jan-Wilhelm Kornfeld, Wolfgang Wagner, Roman Goetzke, Torsten Sieben, Björn Rath, Eduardo Fernandez-Rebollo

Publikováno v: Fernandez-Rebollo, E, Franzen, J, Goetzke, R, Hollmann, J, Ostrowska, A, Oliverio, M, Sieben, T, Rath, B, Kornfeld, J-W & Wagner, W 2020, ' Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells ', Stem Cell Reports, vol. 14, no. 2, pp. 201-209 . https://doi.org/10.1016/j.stemcr.2019.12.012
Stem cell reports 14(2), 201-209 (2020). doi:10.1016/j.stemcr.2019.12.012
Stem Cell Reports
Stem Cell Reports, Vol 14, Iss 2, Pp 201-209 (2020)

Summary Long-term culture of primary cells is characterized by functional and secretory changes, which ultimately result in replicative senescence. It is largely unclear how the metabolome of cells changes during replicative senescence and if such ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3914262abc54e21822b6ed98dc72d9
https://findresearcher.sdu.dk:8443/ws/files/169015320/PIIS2213671119304515.pdf