Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jonathan H. Gooi"'
Autor:
Luke A. Miles, Stefan J. Hermans, Gabriela A.N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andrés A. Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C. Hancock, Michael W. Parker
Publikováno v:
iScience, Vol 19, Iss , Pp 110-118 (2019)
Summary: Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might be an effective therapy aga
Externí odkaz:
https://doaj.org/article/22f8a82eaea94df5bb89f782ed04cc2d
Autor:
Cale Dobrosak, Jonathan H. Gooi
Publikováno v:
Bone Reports, Vol 7, Iss C, Pp 114-120 (2017)
Over the past few years interest has greatly increased in how the lipid mediator sphingosine-1-phosphate (S1P) influences bone homeostasis. Recent work has postulated multiple effects of S1P on osteoblasts and osteoclasts. Based on these findings, S1
Externí odkaz:
https://doaj.org/article/ac2a25cb2db24267961722e623c80519
Autor:
Dae-Chul Cho, Holly J. Brennan, Rachelle W. Johnson, Ingrid J. Poulton, Jonathan H. Gooi, Brett A. Tonkin, Narelle E. McGregor, Emma C. Walker, David J. Handelsman, T. J. Martin, Natalie A. Sims
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The strength of long bones is determined by coalescence of trabeculae during corticalization. Here the authors show that this process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones.
Externí odkaz:
https://doaj.org/article/b957b83bc219453cadc23acf2a9623c9
Publikováno v:
Bone Reports, Vol 6, Iss C, Pp 44-50 (2017)
Vitamin D plays a critical role in skeletal homeostasis. Vitamin D supplementation is used worldwide to maintain optimal bone health, but the most appropriate level of supplementation remains controversial. This study aimed to determine the effects o
Externí odkaz:
https://doaj.org/article/79df7a958bbc4351963ad2333c08ec74
Publikováno v:
Bone Reports, Vol 6, Iss C, Pp 74-80 (2017)
It is generally accepted that bone and muscle possess the capacity to act in an autocrine, paracrine, or endocrine manner, with a growing body of evidence that suggests muscle can secrete muscle specific cytokines or “myokines”, which influence b
Externí odkaz:
https://doaj.org/article/74d1a24e739e498ea508ff817aea6be9
Autor:
Emma C Walker, Kim Truong, Narelle E McGregor, Ingrid J Poulton, Tsuyoshi Isojima, Jonathan H Gooi, T John Martin, Natalie A Sims
Publikováno v:
eLife, Vol 9 (2020)
Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that
Externí odkaz:
https://doaj.org/article/0e2e31dc062d473bb947c073d0b97fe7
Autor:
Tsuyoshi Isojima, Emma C Walker, Ingrid J Poulton, Narelle E McGregor, Ian P Wicks, Jonathan H Gooi, T John Martin, Natalie A Sims
Publikováno v:
Journal of Bone and Mineral Research. 37:1876-1890
Bone strength is determined by the structure and composition of its thickened outer shell (cortical bone), yet the mechanisms controlling cortical consolidation are poorly understood. Cortical bone maturation depends on SOCS3-mediated suppression of
Autor:
Martha Blank, Narelle E. McGregor, Lynn Rowley, Louise H. W. Kung, Blessing Crimeen‐Irwin, Ingrid J. Poulton, Emma C. Walker, Jonathan H. Gooi, Shireen R. Lamandé, Natalie A. Sims, John F. Bateman
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:4021-4031
Autor:
Martha Blank, Narelle E McGregor, Lynn Rowley, Louise HW Kung, Blessing Crimeen-Irwin, Ingrid J Poulton, Emma C Walker, Jonathan H Gooi, Shireen R. Lamande, Natalie A Sims, John F. Bateman
The inherited brittle bone disease osteogenesis imperfecta (OI) is commonly caused by COL1A1 and COL1A2 mutations that disrupt the collagen I triple helix. This causes intracellular endoplasmic reticulum (ER) retention of the misfolded collagen and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05120277a840eb60897de5d4822b7599
https://doi.org/10.1101/2022.02.23.481692
https://doi.org/10.1101/2022.02.23.481692
Autor:
Kenta Ishii, Jonathan H. Gooi, S.J. Hermans, Chen Gao, Gabriela A. N. Crespi, Jasmina Markulić, Nancy C. Hancock, Michael W. Parker, Tracy L. Nero, Craig J. Morton
Publikováno v:
Biophys Rev
Alzheimer’s disease is a common and devastating age-related disease with no effective disease-modifying treatments. Human genetics has implicated a wide range of cell surface receptors as playing a role in the disease, many of which are involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e130c0175c58d64afc330b3ac61c9a
https://europepmc.org/articles/PMC8921391/
https://europepmc.org/articles/PMC8921391/