Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jonathan H Shrimp"'
Autor:
Jayme L. Dahlin, Bruce K. Hua, Beth E. Zucconi, Shawn D. Nelson, Shantanu Singh, Anne E. Carpenter, Jonathan H. Shrimp, Evelyne Lima-Fernandes, Mathias J. Wawer, Lawrence P. W. Chung, Ayushi Agrawal, Mary O’Reilly, Dalia Barsyte-Lovejoy, Magdalena Szewczyk, Fengling Li, Parnian Lak, Matthew Cuellar, Philip A. Cole, Jordan L. Meier, Tim Thomas, Jonathan B. Baell, Peter J. Brown, Michael A. Walters, Paul A. Clemons, Stuart L. Schreiber, Bridget K. Wagner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Cellular nuisance compounds are a burden in chemical biology and drug screening. Here the authors profile prototypical cytotoxic and nuisance compounds using the cell painting assay to systematically characterise cellular morphologies associated with
Externí odkaz:
https://doaj.org/article/a0652f03d5554808827f7867140b6ae5
Autor:
Lei Shi, William Shen, Mindy I. Davis, Ke Kong, Phuong Vu, Supriya K. Saha, Ramzi Adil, Johannes Kreuzer, Regina Egan, Tobie D. Lee, Patricia Greninger, Jonathan H. Shrimp, Wei Zhao, Ting-Yu Wei, Mi Zhou, Jason Eccleston, Jonathan Sussman, Ujjawal Manocha, Vajira Weerasekara, Hiroshi Kondo, Vindhya Vijay, Meng-Ju Wu, Sara E. Kearney, Jeffrey Ho, Joseph McClanaghan, Ellen Murchie, Giovanna S. Crowther, Samarjit Patnaik, Matthew B. Boxer, Min Shen, David T. Ting, William Y. Kim, Ben Z. Stanger, Vikram Deshpande, Cristina R. Ferrone, Cyril H. Benes, Wilhelm Haas, Matthew D. Hall, Nabeel Bardeesy
Publikováno v:
Nature Cancer. 4:365-381
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c3602f7c38d388eae485cdbdd07cffc
https://doi.org/10.1038/s43018-023-00523-0
https://doi.org/10.1038/s43018-023-00523-0
Autor:
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1798-1810.e4 (2020)
Summary: The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to dete
Externí odkaz:
https://doaj.org/article/b3f7874afa484caba2d1087fcf914a16
Autor:
Jayme L. Dahlin, Kathryn M. Nelson, Jessica M. Strasser, Dalia Barsyte-Lovejoy, Magdalena M. Szewczyk, Shawna Organ, Matthew Cuellar, Gurpreet Singh, Jonathan H. Shrimp, Nghi Nguyen, Jordan L. Meier, Cheryl H. Arrowsmith, Peter J. Brown, Jonathan B. Baell, Michael A. Walters
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority ar
Externí odkaz:
https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30
Autor:
Jonathan H. Shrimp, John Janiszewski, Catherine Z. Chen, Miao Xu, Kelli M. Wilson, Stephen C. Kales, Philip E. Sanderson, Paul Shinn, Rick Schneider, Zina Itkin, Hui Guo, Min Shen, Carleen Klumpp-Thomas, Samuel G. Michael, Wei Zheng, Anton Simeonov, Matthew D. Hall
Publikováno v:
ACS Infectious Diseases. 8:1191-1203
SARS-CoV-2 is the causative viral pathogen driving the COVID-19 pandemic that prompted an immediate global response to the development of vaccines and antiviral therapeutics. For antiviral therapeutics, drug repurposing allows for rapid movement of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a8a90490d5fba8e9777010836233a0
https://doi.org/10.1021/acsinfecdis.2c00172
https://doi.org/10.1021/acsinfecdis.2c00172
Autor:
Jonathan D. Licht, Richard B. Lock, Matthew D. Hall, Adolfo A. Ferrando, Richard L. Bennett, Alberto Riva, Min Shen, Christine M. Will, Jon A. Oyer, Marta Kulis, Alok Swaroop, Catalina Troche, Heidi L. Casellas Román, Duohui Jing, Jacob S. Roth, Daphne Dupéré-Richér, Crissandra Piper, Jonathan H. Shrimp, Julia Hlavka-Zhang, Jianping Li
Differentially expressed genes in NSD2 p.E1099K RCH-ACV cells with the change of H3K27me3 peaks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a91870484950660f0812af4a109e7ed
https://doi.org/10.1158/2159-8290.22540601.v1
https://doi.org/10.1158/2159-8290.22540601.v1
Autor:
Jonathan D. Licht, Richard B. Lock, Matthew D. Hall, Adolfo A. Ferrando, Richard L. Bennett, Alberto Riva, Min Shen, Christine M. Will, Jon A. Oyer, Marta Kulis, Alok Swaroop, Catalina Troche, Heidi L. Casellas Román, Duohui Jing, Jacob S. Roth, Daphne Dupéré-Richér, Crissandra Piper, Jonathan H. Shrimp, Julia Hlavka-Zhang, Jianping Li
Supplementary Methods and Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f527e42d7609e21d0ce6a0dc9cd8297f
https://doi.org/10.1158/2159-8290.22540619.v1
https://doi.org/10.1158/2159-8290.22540619.v1
Autor:
Jonathan D. Licht, Richard B. Lock, Matthew D. Hall, Adolfo A. Ferrando, Richard L. Bennett, Alberto Riva, Min Shen, Christine M. Will, Jon A. Oyer, Marta Kulis, Alok Swaroop, Catalina Troche, Heidi L. Casellas Román, Duohui Jing, Jacob S. Roth, Daphne Dupéré-Richér, Crissandra Piper, Jonathan H. Shrimp, Julia Hlavka-Zhang, Jianping Li
Mutations in epigenetic regulators are common in relapsed pediatric acute lymphoblastic leukemia (ALL). Here, we uncovered the mechanism underlying the relapse of ALL driven by an activating mutation of the NSD2 histone methyltransferase (p.E1099K).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d81e3bd352ab69e448030a91c43dd4
https://doi.org/10.1158/2159-8290.c.6549425.v1
https://doi.org/10.1158/2159-8290.c.6549425.v1
Autor:
Frank J Echtenkamp, Ryo Ishida, Genesis M Rivera-Marquez, Marisa Maisiak, Oleta T Johnson, Jonathan H Shrimp, Arnav Sinha, Stephen John Ralph, Ian Nisbet, Murali Krishna Cherukuri, Jason E Gestwicki, Leonard M Neckers
Publikováno v:
PNAS Nexus
PNAS nexus, vol 2, iss 4
PNAS nexus, vol 2, iss 4
The androgen receptor is a key regulator of prostate cancer and the principal target of current prostate cancer therapies collectively termed androgen deprivation therapies. Insensitivity to these drugs is a hallmark of progression to a terminal dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c14ec7cbf7dcddfe214f2794fc2679b
https://europepmc.org/articles/PMC10118397/
https://europepmc.org/articles/PMC10118397/
Autor:
Crissandra Piper, Matthew D. Hall, Marta Kulis, Richard L. Bennett, Alok Swaroop, Min Shen, Richard B. Lock, Jonathan H. Shrimp, Jon A. Oyer, Christine Will, Alberto Riva, Heidi L. Casellas Roman, Duohui Jing, Jianping Li, Catalina Troche, Adolfo A. Ferrando, Jacob S. Roth, Daphné Dupéré-Richer, Jonathan D. Licht, Julia Cathryn Hlavka-Zhang
Publikováno v:
Cancer Discovery. 12:186-203
Mutations in epigenetic regulators are common in relapsed pediatric acute lymphoblastic leukemia (ALL). Here, we uncovered the mechanism underlying the relapse of ALL driven by an activating mutation of the NSD2 histone methyltransferase (p.E1099K).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85fe99475501410ebbd77035ec978838
https://doi.org/10.1158/2159-8290.cd-20-1771
https://doi.org/10.1158/2159-8290.cd-20-1771