Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jonathan H Fox"'
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0250606 (2021)
Huntington's disease (HD) is a neurodegenerative disorder caused by a dominant CAG-repeat expansion in the huntingtin gene. Microglial activation is a key feature of HD pathology, and is present before clinical disease onset. The kynurenine pathway (
Externí odkaz:
https://doaj.org/article/09f6d8fb20fd4f8f8e9c185b729c4aa6
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162404 (2016)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-repeat expansion in the huntingtin protein. Activation of the kynurenine pathway of tryptophan degradation is implicated in the pathogenesis of HD. Indole
Externí odkaz:
https://doaj.org/article/f3393d3dc7904f608e20d1a6a882998a
Autor:
Jianfang Chen, Eileen Marks, Barry Lai, Zhaojie Zhang, James A Duce, Linh Q Lam, Irene Volitakis, Ashley I Bush, Steven Hersch, Jonathan H Fox
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77023 (2013)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-encoding CAG expansion in the huntingtin gene. Iron accumulates in the brains of HD patients and mouse disease models. However, the cellular and subcellul
Externí odkaz:
https://doaj.org/article/65ddefe2e67e47bbae30df0469525f4e
Autor:
Jonathan H Fox, Jibrin A Kama, Gregory Lieberman, Raman Chopra, Kate Dorsey, Vanita Chopra, Irene Volitakis, Robert A Cherny, Ashley I Bush, Steven Hersch
Publikováno v:
PLoS ONE, Vol 2, Iss 3, p e334 (2007)
Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and striatal degeneration. Copper and iron are increased in the striata of
Externí odkaz:
https://doaj.org/article/89ba0b8f672040a4a86f8059589f7a88
Autor:
Marce Vasquez, Madison Vance, Kerry S. Sondgeroth, Jonathan H. Fox, Hally Killion, Hailey Sanderson
Publikováno v:
Journal of Veterinary Diagnostic Investigation. 33:101-103
Chlamydia psittaci has not been reported to cause disease in domestic cats, to our knowledge. In contrast, C. felis infection is common in domestic cats and typically results in conjunctivitis, upper respiratory tract infection, and less frequently p
Autor:
Jonathan H. Fox, Sonal Agrawal
Publikováno v:
Mitochondrion
Huntington's disease (HD) is a progressive ultimately fatal disorder caused by a glutamine-encoding CAG expansion in the huntingtin (HTT) gene that results in degeneration mainly in striatal and cerebro-cortical brain regions. Mitochondrial dysfuncti
Publikováno v:
Free Radical Biology and Medicine. 120:317-329
Mitochondrial bioenergetic dysfunction is involved in neurodegeneration in Huntington's disease (HD). Iron is critical for normal mitochondrial bioenergetics but can also contribute to pathogenic oxidation. The accumulation of iron in the brain occur
Publikováno v:
Veterinary Parasitology: Regional Studies and Reports. 26:100627
The American bison (Bison bison) is an iconic native wildlife species of the Great Plains of North America. Recently, farmed bison have also gained importance to the livestock industry across the United States and Canada. One of the common diseases i
Autor:
Brian F. Porter, Justin R. V. Hildenbrand, Jonathan H. Fox, Pierre Hélie, James Smylie, Donal O’Toole, Leslie Easterwood
Publikováno v:
Journal of Veterinary Diagnostic Investigation. 30:280-285
Metal phosphides, particularly zinc and aluminum phosphide, occasionally poison horses and other equids following their use as rodenticides and insecticides. Grain-based aluminum phosphide baits are used to control rodents such as prairie dogs. The c
Autor:
Ryan Nelson, Justin R. V. Hildenbrand, Jonathan H. Fox, Sonal Agrawal, Kiersten L. Berggren, Julia A. Fox, Ashley I. Bush
Publikováno v:
Journal of Huntington's Disease. 6:115-125
BACKGROUND: Huntington’s disease (HD) is an autosomal dominant disorder caused by a CAG expansion in the huntingtin gene that results in expression of mutant huntingtin protein. Iron accumulates in HD brain neurons. Amyloid precursor protein (APP)